Protein: JUN
Transcription factor Jun (AH119) (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (Transcription factor AP-1 subunit Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (Jun A)

Gene: JUN
Organism: Mus musculus
Interactions: 78
UniProt ID: P05627

Gene Ontology (top 5):
GO:0000791 - euchromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

370832

FOS
Protein c-Fos

7

20

Small-scale

0.957

High

432044

JUN
Transcription factor Jun

2

19

Small-scale

0.775

High

432071

MAFB
Transcription factor MafB

2

20

Small-scale

0.757

High

432100

MK08
Mitogen-activated protein kinase 8

11

20

Small-scale

0.755

High

432086

ATF3
Cyclic AMP-dependent transcription factor ATF-3

2

20

Small-scale

0.754

High

432082

ATF4
Cyclic AMP-dependent transcription factor ATF-4

2

8

Small-scale

0.743

High

432066

NOS2
Nitric oxide synthase, inducible

4

3

Small-scale

0.676

High

432060

SPI1
Transcription factor PU.1

3

19

Small-scale

0.650

High

432057

FOSB
Protein FosB

1

20

Small-scale

0.618

High

432077

CREB1
Cyclic AMP-responsive element-binding protein 1

1

18

Small-scale

0.618

High

432080

TF65
Transcription factor p65

1

20

Small-scale

0.618

High

432101

SIR1
NAD-dependent protein deacetylase sirtuin-1

2

4

Small-scale

0.612

High

432046

TNFA
Tumor necrosis factor

2

6

Small-scale

0.601

High

432068

STAT3
Signal transducer and activator of transcription 3

2

7

Small-scale

0.586

High

432054

IL1B
Interleukin-1 beta

2

3

Small-scale

0.584

High

432045

GCR
Glucocorticoid receptor

1

18

Small-scale

0.536

High

432089

CDK6
Cyclin-dependent kinase 6

1

2

Small-scale

0.536

High

378657

IL2RA
Interleukin-2 receptor subunit alpha

2

2

Small-scale

0.533

High

432069

HHEX
Hematopoietically-expressed homeobox protein Hhex

1

11

Small-scale

0.527

High

405578

GRAB
Granzyme B(G,H)

1

3

Small-scale

0.515

High

432049

ITB1
Integrin beta-1

1

2

High-throughput

0.501

High

432097

CASP9
Caspase-9

1

2

Small-scale

0.501

High

432059

MECOM
Histone-lysine N-methyltransferase MECOM

1

11

Small-scale

0.500

High

148078

BARX2
Homeobox protein BarH-like 2

1

15

High-throughput

0.481

High

205601

CSN5
COP9 signalosome complex subunit 5

1

8

Small-scale

0.481

High

432048

HXC8
Homeobox protein Hox-C8

1

11

Small-scale

0.481

High

432050

HME1
Homeobox protein engrailed-1

1

10

Small-scale

0.481

High

432052

HXA9
Homeobox protein Hox-A9

1

9

Small-scale

0.481

High

432096

SMAD3
Mothers against decapentaplegic homolog 3

1

9

Small-scale

0.481

High

59094

ZEP3
Transcription factor HIVEP3

1

6

Small-scale

0.479

High

74246

EP300
Histone acetyltransferase p300

1

20

High-throughput

0.479

High

148758

PTGDS
Prostaglandin-H2 D-isomerase

1

4

Small-scale

0.479

High

312860

CTBP1
C-terminal-binding protein 1

1

4

High-throughput

0.479

High

313389

SP1
Transcription factor Sp1

1

9

Small-scale

0.479

High

362433

ABL1
Tyrosine-protein kinase ABL1

1

3

Small-scale

0.479

High

373660

MYC
Myc proto-oncogene protein

1

7

Small-scale

0.479

High

378449

IFNG
Interferon gamma

1

5

Small-scale

0.479

High

378462

IL1A
Interleukin-1 alpha

1

1

Small-scale

0.479

High

432047

IL6
Interleukin-6

1

1

Small-scale

0.479

High

432051

CSF1R
Macrophage colony-stimulating factor 1 receptor

1

3

Small-scale

0.479

High

432053

CCL2
C-C motif chemokine 2

1

10

Small-scale

0.479

High

432056

A4
Amyloid-beta precursor protein

1

7

Small-scale

0.479

High

432063

ESR1
Estrogen receptor

1

19

Small-scale

0.479

High

432065

DUS1
Dual specificity protein phosphatase 1

1

2

Small-scale

0.479

High

432070

BRCA1
Breast cancer type 1 susceptibility protein homolog

1

15

Small-scale

0.479

High

432076

I12R2
Interleukin-12 receptor subunit beta-2

1

4

Small-scale

0.479

High

432078

CTNB1
Catenin beta-1

1

7

Small-scale

0.479

High

432081

SOX8
Transcription factor SOX-8

1

19

Small-scale

0.479

High

432083

PRDM1
PR domain zinc finger protein 1

1

10

Small-scale

0.479

High

432087

SOX17
Transcription factor SOX-17

1

18

Small-scale

0.479

High

432088

CCL12
C-C motif chemokine 12

1

10

Small-scale

0.479

High

432090

ZBT7B
Zinc finger and BTB domain-containing protein 7B

1

16

High-throughput

0.479

High

432091

H2B1B
Histone H2B type 1-B

1

7

Small-scale

0.479

High

432092

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

11

Small-scale

0.479

High

432093

SPOP
Speckle-type POZ protein

1

5

High-throughput

0.479

High

432098

ITCH
E3 ubiquitin-protein ligase Itchy

1

5

Small-scale

0.479

High

432102

IL23A
Interleukin-23 subunit alpha

1

1

Small-scale

0.479

High

432103

TLR9
Toll-like receptor 9

1

1

Small-scale

0.479

High

432104

Q9JM08
Histone deacetylase

1

14

Small-scale

0.479

High

432105

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

1

Small-scale

0.479

High

432064

MFGM
Lactadherin

1

0

Small-scale

0.458

High

432075

IL18
Interleukin-18

1

0

Small-scale

0.458

High

432084

ITF2
Transcription factor 4

1

0

Small-scale

0.458

High

432085

BAG1
BAG family molecular chaperone regulator 1

1

0

Small-scale

0.458

High

432094

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

Small-scale

0.458

High

432099

SNPC5
snRNA-activating protein complex subunit 5

1

1

Small-scale

0.457

High

432072

TDG
G/T mismatch-specific thymine DNA glycosylase

1

1

Small-scale

0.457

High

107133

F8VQ72
Mitogen-activated protein kinase kinase kinase 1

1

3

Small-scale

0.437

High

432055

CXCL2
C-X-C motif chemokine 2

1

5

Small-scale

0.437

High

432058

CCL4
C-C motif chemokine 4

1

10

Small-scale

0.437

High

432061

CXL10
C-X-C motif chemokine 10

1

5

Small-scale

0.437

High

432062

CXCL9
C-X-C motif chemokine 9

1

5

Small-scale

0.437

High

432067

MMP13
Collagenase 3

1

4

Small-scale

0.437

High

432079

CCL7
C-C motif chemokine 7

1

10

Small-scale

0.437

High

432095

Q8BK32
Nuclear receptor co-repressor 1

1

3

Small-scale

0.437

High

432073

TPM1
Tropomyosin alpha-1 chain

1

11

Small-scale

0.417

High

432074

TPM2
Tropomyosin beta chain

1

11

Small-scale

0.417

High


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Last updated: 11Aug2025