HitPredict

Interactor 1: PSB4 (P22141)
Proteasome subunit beta type-4 (Macropain subunit C11) (Multicatalytic endopeptidase complex subunit C11) (Proteasome component C11) (Proteinase YSCE subunit 11)
Gene: PRE1

Interactor 2: RPN6 (Q12377)
26S proteasome regulatory subunit RPN6 (Proteasome non-ATPase subunit 4)
Gene: RPN6

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.881

Property	Details
Experiments	11029046, 37968396, 15242647, 21878652
Identification Methods	coimmunoprecipitation, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Proteasome~RPN6_N
Common GO terms	GO:0000502 - proteasome complex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 198 Sc			1 434
+	Dm
		1180720 Q9VJJ0_DROME (1-197): 4.53e-85: 251: 40.10		PSD11_DROME (3-433): 1.12e-99: 306: 44.44
+	Hs
		121708 PSB2_HUMAN (1-196): 1.09e-76: 230: 44.39		PSD11_HUMAN (1-433): 4.6e-98: 301: 41.01
+	Dm
		1178939 Q7K148_DROME (2-197): 2.75e-66: 206: 20.92		PSD11_DROME (3-433): 1.12e-99: 306: 44.44
+	Hs
		121692 PSB5_HUMAN (2-197): 5.07e-66: 205: 20.92		PSD11_HUMAN (1-433): 4.6e-98: 301: 41.01
+	Dm
		1180724 Q9VUJ1_DROME (4-197): 1.8e-63: 199: 22.68		PSD11_DROME (3-433): 1.12e-99: 306: 44.44
+	Hs
		121838 PSB7_HUMAN (3-197): 4.25e-65: 203: 21.54		PSD11_HUMAN (1-433): 4.6e-98: 301: 41.01
+	Dm
		771297 PSA2_DROME (4-198): 2.91e-63: 197: 19.29		PSD11_DROME (3-433): 1.12e-99: 306: 44.44
+	Hs
		121684 PSA2_HUMAN (4-198): 2.88e-64: 199: 20.31		PSD11_HUMAN (1-433): 4.6e-98: 301: 41.01
+	Hs
		121685 PSA4_HUMAN (3-198): 2.29e-62: 195: 18.72		PSD11_HUMAN (1-433): 4.6e-98: 301: 41.01
+	Dm
		1358529 Q9VJJ0_DROME (1-197): 4.53e-85: 251: 40.10		PSMD6_DROME (53-432): 3.17e-69: 226: 13.35
+	Hs
		832104 PSB2_HUMAN (1-196): 1.09e-76: 230: 44.39		PSMD6_HUMAN (65-432): 1.66e-73: 237: 13.78
+	Hs
		656717 PSB5_HUMAN (2-197): 5.07e-66: 205: 20.92		PSMD6_HUMAN (65-432): 1.66e-73: 237: 13.78
+	Hs
		1062861 PSB7_HUMAN (3-197): 4.25e-65: 203: 21.54		PSMD6_HUMAN (65-432): 1.66e-73: 237: 13.78
+	Hs
		637690 PSA2_HUMAN (4-198): 2.88e-64: 199: 20.31		PSMD6_HUMAN (65-432): 1.66e-73: 237: 13.78
+	Dm
		1178948 Q7K148_DROME (2-197): 2.75e-66: 206: 20.92		PSMD6_DROME (53-432): 3.17e-69: 226: 13.35
+	Hs
		638133 PSA4_HUMAN (3-198): 2.29e-62: 195: 18.72		PSMD6_HUMAN (65-432): 1.66e-73: 237: 13.78
+	Dm
		1358534 Q9VUJ1_DROME (4-197): 1.8e-63: 199: 22.68		PSMD6_DROME (53-432): 3.17e-69: 226: 13.35
+	Dm
		771305 PSA2_DROME (4-198): 2.91e-63: 197: 19.29		PSMD6_DROME (53-432): 3.17e-69: 226: 13.35
+	Dm
		1358200 Q9VJJ0_DROME (1-197): 4.53e-85: 251: 40.10		CSN4_DROME (137-426): 9.88e-19: 89.5: 15.56
+	Dm
		771304 PSA2_DROME (4-198): 2.91e-63: 197: 19.29		CSN4_DROME (137-426): 9.88e-19: 89.5: 15.56