HitPredict

Interactor 1: MED6 (O75586)
Mediator of RNA polymerase II transcription subunit 6 (Activator-recruited cofactor 33 kDa component) (ARC33) (Mediator complex subunit 6) (hMed6) (Renal carcinoma antigen NY-REN-28)
Gene: MED6

Interactor 2: MED8 (Q96G25)
Mediator of RNA polymerase II transcription subunit 8 (Activator-recruited cofactor 32 kDa component) (ARC32) (Mediator complex subunit 8)
Gene: MED8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

The method score is based on:

Property	Details
Experiments	35271311, 24981860
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	Med6~Med8
Common GO terms	GO:0000151 - ubiquitin ligase complex GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0016592 - mediator complex and 6 others more... GO:0016567 - protein ubiquitination GO:0032968 - positive regulation of transcription elongation by RNA polymerase II GO:0051123 - RNA polymerase II preinitiation complex assembly GO:0060261 - positive regulation of transcription initiation by RNA polymerase II GO:0061630 - ubiquitin protein ligase activity GO:0070847 - core mediator complex
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1	246
Hs

1	268

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024