HitPredict

Interactor 1: VP37C (A5D8V6)
Vacuolar protein sorting-associated protein 37C (hVps37C) (ESCRT-I complex subunit VPS37C)
Gene: VPS37C

Interactor 2: HGS (O14964)
Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110)
Gene: HGS

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	25416956, 15509564
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016236 - macroautophagy GO:0036258 - multivesicular body assembly GO:0043328 - protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0070062 - extracellular exosome GO:0090148 - membrane fission
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 355 Hs			1 777
+	Hs
		160195 VP37B_HUMAN (7-246): 1.32e-31: 122: 38.17		HGS_HUMAN (1-777): 5.12e-104: 338: 100.00
+	Hs
		60538 VP37C_HUMAN (1-350): 2.64e-47: 165: 100.00		TOM1_HUMAN (5-428): 1.81e-54: 197: 18.16
+	Hs
		60541 VP37C_HUMAN (1-350): 2.64e-47: 165: 100.00		STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91
+	At
		1226458 VP371_ARATH (4-156): 2.72e-48: 164: 29.22		TOL9_ARATH (8-673): 1.54e-36: 148: 15.29
+	Hs
		277094 VP37A_HUMAN (1-157): 3.22e-26: 109: 25.48		STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91
+	Hs
		1189509 VP37A_HUMAN (1-157): 3.22e-26: 109: 25.48		ZFY16_HUMAN (137-497): 7.73e-39: 158: 17.76
+	Hs
		203256 SYNJ1_HUMAN (83-341): 4.85e-25: 108: 16.40		ANFY1_HUMAN (156-219): 2.38e-14: 79.3: 50.00
+	Mm
		1351630 PCLO_MOUSE (94-296): 1.66e-10: 64.7: 14.42		PCLO_MOUSE (227-739): 8.86e-09: 61.6: 11.93