Protein: SYPM
Probable proline--tRNA ligase, mitochondrial (EC 6.1.1.15) (Prolyl-tRNA synthetase) (ProRS) (Prolyl-tRNA synthetase 2, mitochondrial)

Gene: SYPM, PARS2
Organism: Homo sapiens
Interactions: 42
UniProt ID: Q7L3T8

Gene Ontology (top 5):
GO:0004827 - proline-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0006433 - prolyl-tRNA aminoacylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

484581

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

3

3

High-throughput

0.667

High

1095400

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

3

1

High-throughput

0.650

High

930733

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

2

1

High-throughput

0.611

High

275319

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

1

1

High-throughput

0.536

High

690515

KAD4
Adenylate kinase 4, mitochondrial

1

1

High-throughput

0.536

High

1123330

ICT1
Large ribosomal subunit protein mL62

1

1

High-throughput

0.536

High

1272066

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

3

High-throughput

0.536

High

1272069

RT24
Small ribosomal subunit protein uS3m

1

1

High-throughput

0.536

High

1272080

PIN4
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4

1

1

High-throughput

0.536

High

1272081

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

1

High-throughput

0.536

High

225620

AAKB2
5'-AMP-activated protein kinase subunit beta-2

2

3

High-throughput

0.521

High

1272067

SH2D3
SH2 domain-containing protein 3C

2

3

High-throughput

0.521

High

591424

NQO2
Ribosyldihydronicotinamide dehydrogenase [quinone]

1

1

High-throughput

0.489

High

1272077

DJB11
DnaJ homolog subfamily B member 11

1

3

High-throughput

0.489

High

1272083

EMIL1
EMILIN-1

1

2

High-throughput

0.489

High

242102

PRKN
E3 ubiquitin-protein ligase parkin

1

6

High-throughput

0.479

High

315724

RECQ4
ATP-dependent DNA helicase Q4

1

3

High-throughput

0.479

High

930328

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

2

High-throughput

0.479

High

1107859

SQSTM
Sequestosome-1

1

1

High-throughput

0.445

High

830966

CCNF
Cyclin-F

1

5

High-throughput

0.437

High

867239

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.437

High

904871

MECP2
Methyl-CpG-binding protein 2

1

1

High-throughput

0.437

High

1113510

CUL3
Cullin-3

1

7

High-throughput

0.437

High

1178219

CL16A
Protein CLEC16A

1

1

High-throughput

0.437

High

1254375

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.437

High

1272070

DDRGK
DDRGK domain-containing protein 1

1

3

High-throughput

0.437

High

1272073

PKHA4
Pleckstrin homology domain-containing family A member 4

1

8

High-throughput

0.437

High

1272074

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.437

High

1272082

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

3

High-throughput

0.437

High

430077

JUN
Transcription factor Jun

1

8

High-throughput

0.407

High

253018

LMX1B
LIM homeobox transcription factor 1-beta

3

0

High-throughput

0.347

High

1272071

HSPB9
Heat shock protein beta-9

3

0

High-throughput

0.347

High

540521

LAMP1
Lysosome-associated membrane glycoprotein 1

1

0

High-throughput

0.279

Low

1061596

FOXM1
Forkhead box protein M1

1

0

High-throughput

0.279

Low

1272068

PCAT1
Lysophosphatidylcholine acyltransferase 1

1

0

High-throughput

0.279

Low

1272072

IL25
Interleukin-25

1

0

High-throughput

0.279

Low

1272075

ZC4H2
Zinc finger C4H2 domain-containing protein

1

0

High-throughput

0.279

Low

1272076

STIM2
Stromal interaction molecule 2

1

0

High-throughput

0.279

Low

1272079

DSE
Dermatan-sulfate epimerase

1

0

High-throughput

0.279

Low

342232

BRD1
Bromodomain-containing protein 1

1

0

High-throughput

0.249

Low

2139

KVD13
Immunoglobulin kappa variable 1D-13

1

0

High-throughput

0.232

Low

1272078

FBX3
F-box only protein 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025