HitPredict

Interactor 1: UBA1 (P22515)
Ubiquitin-activating enzyme E1 1 (EC 6.2.1.45)
Gene: UBA1

Interactor 2: UBC12 (P52491)
NEDD8-conjugating enzyme UBC12 (EC 2.3.2.34) (RUB1-conjugating enzyme) (Ubiquitin carrier protein 12)
Gene: UBC12

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	21940857
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	E1_UFD~UQ_con, ThiF~UQ_con
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1024 Sc			1 188
+	Sc
		549788 UBA1_YEAST (1-1024): 0: 1089: 100.00		UBC4_YEAST (27-177): 7.92e-75: 223: 27.82
+	Sp
		293848 UBA1_SCHPO (1-1024): 0: 1038: 58.29		UBC4_SCHPO (28-177): 1.86e-74: 222: 30.00
+	Dm
		715098 Q8T0L3_DROME (2-1024): 0: 1017: 49.18		UBE2N_DROME (25-179): 2.05e-66: 202: 30.32
+	Hs
		48107 UBA6_HUMAN (2-1024): 0: 966: 40.81		UB2D2_HUMAN (28-177): 1.49e-76: 227: 28.67
+	Hs
		48104 UBA6_HUMAN (2-1024): 0: 966: 40.81		UB2D1_HUMAN (28-177): 5.12e-76: 225: 29.33
+	Hs
		48106 UBA6_HUMAN (2-1024): 0: 966: 40.81		UB2D3_HUMAN (28-177): 4.63e-75: 223: 28.67
+	Sc
		410211 UBA1_YEAST (1-1024): 0: 1089: 100.00		UBC2_YEAST (26-172): 2.93e-21: 87.4: 34.90
+	Hs
		782203 UBA7_HUMAN (5-1024): 0: 909: 36.99		UB2E1_HUMAN (5-177): 9.53e-73: 219: 27.01
+	Sp
		293847 UBA1_SCHPO (1-1024): 0: 1038: 58.29		UBC2_SCHPO (26-172): 6.89e-20: 83.2: 33.33
+	Sp
		142467 UBA1_SCHPO (1-1024): 0: 1038: 58.29		UBC13_SCHPO (70-163): 1.69e-19: 82: 40.43
+	Hs
		1282360 SAE2_HUMAN (24-413): 8.43e-82: 280: 15.72		UB2E3_HUMAN (10-177): 1.63e-74: 224: 26.79
+	Dm
		1182378 Q7KUA4_DROME (25-417): 2.89e-76: 267: 13.57		UBC2M_DROME (1-183): 4.79e-70: 212: 44.81
+	Hs
		896245 SAE1_HUMAN (409-706): 1.78e-61: 215: 20.46		UBC12_HUMAN (1-183): 1.85e-70: 213: 41.62
+	Hs
		919796 UBA3_HUMAN (790-994): 5.83e-41: 159: 14.55		UB2D2_HUMAN (28-177): 1.49e-76: 227: 28.67
+	Hs
		896154 UBA3_HUMAN (790-994): 5.83e-41: 159: 14.55		UBC12_HUMAN (1-183): 1.85e-70: 213: 41.62
+	Dm
		1181845 Q7KSM5_DROME (408-574): 6.88e-38: 147: 22.16		UBC2M_DROME (1-183): 4.79e-70: 212: 44.81
+	Hs
		607026 UBA1_HUMAN (393-622): 1.44e-27: 123: 17.75		UB2D1_HUMAN (28-177): 5.12e-76: 225: 29.33
+	Hs
		607028 UBA1_HUMAN (393-622): 1.44e-27: 123: 17.75		UB2E1_HUMAN (5-177): 9.53e-73: 219: 27.01
+	Hs
		607023 UBA1_HUMAN (393-622): 1.44e-27: 123: 17.75		UBE2A_HUMAN (25-175): 4.56e-68: 206: 33.78
+	Hs
		1252654 UBA3_HUMAN (790-994): 5.83e-41: 159: 14.55		UBE2F_HUMAN (64-168): 8.87e-19: 81.3: 39.29