Protein: M3K3
Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3)

Gene: M3K3, MAP3K3
Organism: Homo sapiens
Interactions: 210
UniProt ID: Q99759

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0001568 - blood vessel development
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004709 - MAP kinase kinase kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1026825

MP2K5
Dual specificity mitogen-activated protein kinase kinase 5

10

16

Small-scale

0.981

High

1306369

M3K3
Mitogen-activated protein kinase kinase kinase 3

4

16

Small-scale

0.885

High

1038311

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

4

20

Small-scale

0.873

High

338896

EGFR
Epidermal growth factor receptor

3

15

High-throughput

0.843

High

1306407

M3K2
Mitogen-activated protein kinase kinase kinase 2

3

16

Small-scale

0.834

High

1306371

CCM2
Cerebral cavernous malformations 2 protein

3

0

Small-scale

0.825

High

201410

M3K7
Mitogen-activated protein kinase kinase kinase 7

2

10

Small-scale

0.815

High

801000

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

2

19

Small-scale

0.812

High

1036842

SQSTM
Sequestosome-1

2

8

Small-scale

0.806

High

805462

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

2

17

Small-scale

0.778

High

158532

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

2

20

Small-scale

0.754

High

432200

HS90A
Heat shock protein HSP 90-alpha

2

20

Small-scale

0.754

High

475158

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

2

17

High-throughput

0.754

High

924126

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

2

15

High-throughput

0.754

High

924395

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

2

13

High-throughput

0.754

High

909957

1433E
14-3-3 protein epsilon

7

15

Small-scale

0.747

High

905036

1433G
14-3-3 protein gamma

6

20

High-throughput

0.734

High

927454

1433Z
14-3-3 protein zeta/delta

6

20

High-throughput

0.732

High

982424

1433F
14-3-3 protein eta

6

20

High-throughput

0.732

High

647221

1433T
14-3-3 protein theta

6

20

Small-scale

0.729

High

683663

1433B
14-3-3 protein beta/alpha

6

20

Small-scale

0.727

High

325864

LATS1
Serine/threonine-protein kinase LATS1

1

17

Small-scale

0.724

High

436748

GLI1
Zinc finger protein GLI1

1

2

Small-scale

0.724

High

1035399

GAB1
GRB2-associated-binding protein 1

1

6

Small-scale

0.724

High

1306410

TRAF6
TNF receptor-associated factor 6

4

19

Small-scale

0.692

High

1082942

CDC37
Hsp90 co-chaperone Cdc37

1

7

High-throughput

0.665

High

1183109

MARK2
Serine/threonine-protein kinase MARK2

1

16

High-throughput

0.665

High

984014

ZBT16
Zinc finger and BTB domain-containing protein 16

1

0

High-throughput

0.663

High

1163029

TRAF7
E3 ubiquitin-protein ligase TRAF7

5

8

Small-scale

0.654

High

117027

SGK1
Serine/threonine-protein kinase Sgk1

1

14

Small-scale

0.647

High

153166

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

1

16

Small-scale

0.647

High

647664

MK03
Mitogen-activated protein kinase 3

1

18

Small-scale

0.647

High

659033

MK01
Mitogen-activated protein kinase 1

1

18

Small-scale

0.647

High

2078

A0A0B4J269
Tubulin beta-3 chain

1

15

High-throughput

0.618

High

161438

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

7

High-throughput

0.618

High

167605

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

20

High-throughput

0.618

High

228481

PRKN
E3 ubiquitin-protein ligase parkin

1

20

High-throughput

0.618

High

433969

LYN
Tyrosine-protein kinase Lyn

1

20

High-throughput

0.618

High

438469

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

476266

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

17

High-throughput

0.618

High

509718

UBL4A
Ubiquitin-like protein 4A

1

20

High-throughput

0.618

High

580685

ML12A
Myosin regulatory light chain 12A

1

9

High-throughput

0.618

High

636404

DNJB1
DnaJ homolog subfamily B member 1

1

10

High-throughput

0.618

High

672259

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

7

High-throughput

0.618

High

672465

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

1

7

High-throughput

0.618

High

681575

DNJA1
DnaJ homolog subfamily A member 1

1

11

High-throughput

0.618

High

682952

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

3

High-throughput

0.618

High

727007

FUS
RNA-binding protein FUS

1

2

High-throughput

0.618

High

848459

IRAK1
Interleukin-1 receptor-associated kinase 1

1

7

Small-scale

0.618

High

882520

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

9

High-throughput

0.618

High

929982

ACTG
Actin, cytoplasmic 2

1

9

High-throughput

0.618

High

1021556

DLG1
Disks large homolog 1

1

2

High-throughput

0.618

High

1045495

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

9

High-throughput

0.618

High

1056108

NBR1
Next to BRCA1 gene 1 protein

1

1

Small-scale

0.618

High

1082353

DDB1
DNA damage-binding protein 1

1

5

High-throughput

0.618

High

1167410

MPRIP
Myosin phosphatase Rho-interacting protein

1

10

High-throughput

0.618

High

1270125

TFG
Protein TFG

1

3

High-throughput

0.618

High

1290477

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

9

High-throughput

0.618

High

1305074

DNJC7
DnaJ homolog subfamily C member 7

1

3

High-throughput

0.618

High

1306377

UACA
Uveal autoantigen with coiled-coil domains and ankyrin repeats

1

5

High-throughput

0.618

High

1306379

MYLK2
Myosin light chain kinase 2, skeletal/cardiac muscle

1

16

High-throughput

0.618

High

1306384

LATS2
Serine/threonine-protein kinase LATS2

1

19

Small-scale

0.618

High

1306388

RAI14
Ankycorbin

1

7

High-throughput

0.618

High

1306391

DNJB4
DnaJ homolog subfamily B member 4

1

10

High-throughput

0.618

High

1306392

Q9UFQ0
Uncharacterized protein DKFZp434K0435

1

17

High-throughput

0.618

High

1306399

ALK
ALK tyrosine kinase receptor

1

13

High-throughput

0.618

High

280451

GLRX3
Glutaredoxin-3

2

4

High-throughput

0.613

High

573438

TCPA
T-complex protein 1 subunit alpha

2

14

High-throughput

0.611

High

826842

TCPG
T-complex protein 1 subunit gamma

2

14

High-throughput

0.611

High

843013

TCPQ
T-complex protein 1 subunit theta

2

20

High-throughput

0.611

High

843350

TCPD
T-complex protein 1 subunit delta

2

14

High-throughput

0.611

High

1306370

TCPH
T-complex protein 1 subunit eta

2

16

High-throughput

0.611

High

808880

YAP1
Transcriptional coactivator YAP1

1

18

Small-scale

0.561

High

1306382

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

12

Small-scale

0.561

High

749817

BRCA1
Breast cancer type 1 susceptibility protein

1

4

Small-scale

0.552

High

1272562

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.541

High

808243

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

12

High-throughput

0.536

High

957771

XIAP
E3 ubiquitin-protein ligase XIAP

1

11

Small-scale

0.536

High

942237

GTF2I
General transcription factor II-I

1

0

High-throughput

0.518

High

714380

HSP74
Heat shock 70 kDa protein 4

1

13

High-throughput

0.515

High

272817

TM1L1
TOM1-like protein 1

1

6

High-throughput

0.508

High

362101

MBP
Myelin basic protein

1

3

Small-scale

0.501

High

1036333

BIRC2
Baculoviral IAP repeat-containing protein 2

1

13

Small-scale

0.501

High

1058708

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

2

Small-scale

0.501

High

1069266

2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

1

2

Small-scale

0.501

High

1299609

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

12

High-throughput

0.501

High

380922

VWF
von Willebrand factor

1

3

High-throughput

0.494

High

1306385

PDRG1
p53 and DNA damage-regulated protein 1

1

0

High-throughput

0.493

High

1306394

PFD2
Prefoldin subunit 2

1

0

High-throughput

0.493

High

117804

MYO1C
Unconventional myosin-Ic

1

12

High-throughput

0.479

High

163187

XPO1
Exportin-1

1

6

High-throughput

0.479

High

165022

SC16A
Protein transport protein Sec16A

1

1

High-throughput

0.479

High

197383

SERA
D-3-phosphoglycerate dehydrogenase

1

1

High-throughput

0.479

High

207987

XPOT
Exportin-T

1

5

High-throughput

0.479

High

211649

ACTN4
Alpha-actinin-4

1

3

High-throughput

0.479

High

214651

MYO1B
Unconventional myosin-Ib

1

15

High-throughput

0.479

High

229727

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

10

Small-scale

0.479

High

295662

RMP
Unconventional prefoldin RPB5 interactor 1

1

2

High-throughput

0.479

High

297398

MYO1D
Unconventional myosin-Id

1

12

High-throughput

0.479

High

323989

BAG2
BAG family molecular chaperone regulator 2

1

2

High-throughput

0.479

High

325344

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

2

High-throughput

0.479

High

381279

TBB4A
Tubulin beta-4A chain

1

14

High-throughput

0.479

High

382122

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

2

High-throughput

0.479

High

391453

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

6

High-throughput

0.479

High

396789

S10A8
Protein S100-A8

1

6

High-throughput

0.479

High

428385

TBB5
Tubulin beta chain

1

15

High-throughput

0.479

High

443752

VIME
Vimentin

1

9

High-throughput

0.479

High

444774

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

7

High-throughput

0.479

High

502471

BIP
Endoplasmic reticulum chaperone BiP

1

14

High-throughput

0.479

High

504640

HSP7C
Heat shock cognate 71 kDa protein

1

9

High-throughput

0.479

High

564164

HSP76
Heat shock 70 kDa protein 6

1

10

High-throughput

0.479

High

570002

CEBPB
CCAAT/enhancer-binding protein beta

1

2

High-throughput

0.479

High

571764

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

1

3

High-throughput

0.479

High

598291

FLNA
Filamin-A

1

9

High-throughput

0.479

High

617645

CRCM
Colorectal mutant cancer protein

1

5

High-throughput

0.479

High

637035

ATPA
ATP synthase subunit alpha, mitochondrial

1

6

High-throughput

0.479

High

653352

PYR1
Multifunctional protein CAD

1

4

High-throughput

0.479

High

678496

S10A7
Protein S100-A7

1

8

High-throughput

0.479

High

714056

HS71L
Heat shock 70 kDa protein 1-like

1

9

High-throughput

0.479

High

724983

MYH9
Myosin-9

1

4

High-throughput

0.479

High

725229

MYH10
Myosin-10

1

4

High-throughput

0.479

High

737454

LONM
Lon protease homolog, mitochondrial

1

5

High-throughput

0.479

High

738002

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

15

High-throughput

0.479

High

751795

GRP75
Stress-70 protein, mitochondrial

1

20

High-throughput

0.479

High

771003

TCPZ
T-complex protein 1 subunit zeta

1

14

High-throughput

0.479

High

783097

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

787551

MTOR
Serine/threonine-protein kinase mTOR

1

11

Small-scale

0.479

High

788898

RS27
Small ribosomal subunit protein eS27

1

4

High-throughput

0.479

High

809414

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

8

High-throughput

0.479

High

813706

CAPZB
F-actin-capping protein subunit beta

1

3

High-throughput

0.479

High

821380

TCPE
T-complex protein 1 subunit epsilon

1

17

High-throughput

0.479

High

826045

FAS
Fatty acid synthase

1

3

High-throughput

0.479

High

839974

F10A1
Hsc70-interacting protein

1

18

High-throughput

0.479

High

857203

CAZA1
F-actin-capping protein subunit alpha-1

1

2

High-throughput

0.479

High

871753

HSP72
Heat shock-related 70 kDa protein 2

1

10

High-throughput

0.479

High

875254

TERA
Transitional endoplasmic reticulum ATPase

1

4

High-throughput

0.479

High

880161

SYMC
Methionine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.479

High

885301

EPIPL
Epiplakin

1

10

High-throughput

0.479

High

891590

MYL6
Myosin light polypeptide 6

1

6

High-throughput

0.479

High

906105

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

15

High-throughput

0.479

High

908108

RS16
Small ribosomal subunit protein uS9

1

2

High-throughput

0.479

High

919490

RL23
Large ribosomal subunit protein uL14

1

2

High-throughput

0.479

High

921036

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

4

High-throughput

0.479

High

921695

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

4

High-throughput

0.479

High

930968

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

13

Small-scale

0.479

High

943430

TCPB
T-complex protein 1 subunit beta

1

17

High-throughput

0.479

High

944391

PRKDC
DNA-dependent protein kinase catalytic subunit

1

11

High-throughput

0.479

High

960944

CLH1
Clathrin heavy chain 1

1

2

High-throughput

0.479

High

963402

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

10

High-throughput

0.479

High

984423

EF1A2
Elongation factor 1-alpha 2

1

5

High-throughput

0.479

High

990264

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

2

High-throughput

0.479

High

1022860

STRN3
Striatin-3

1

8

Small-scale

0.479

High

1037364

TBB3
Tubulin beta-3 chain

1

15

High-throughput

0.479

High

1040049

IQGA2
Ras GTPase-activating-like protein IQGAP2

1

11

High-throughput

0.479

High

1085042

DREB
Drebrin

1

2

High-throughput

0.479

High

1175130

TBA1A
Tubulin alpha-1A chain

1

6

High-throughput

0.479

High

1175346

RS27L
Ribosomal protein eS27-like

1

4

High-throughput

0.479

High

1224669

ST134
Putative protein FAM10A4

1

17

High-throughput

0.479

High

1234121

Q8N532
TUBA1C protein

1

8

High-throughput

0.479

High

1267853

CNOT9
CCR4-NOT transcription complex subunit 9

1

1

High-throughput

0.479

High

1299163

IP6K3
Inositol hexakisphosphate kinase 3

1

2

High-throughput

0.479

High

1306372

TBB6
Tubulin beta-6 chain

1

15

High-throughput

0.479

High

1306374

RN126
E3 ubiquitin-protein ligase RNF126

1

7

High-throughput

0.479

High

1306375

TBB2B
Tubulin beta-2B chain

1

15

High-throughput

0.479

High

1306376

KIFC3
Kinesin-like protein KIFC3

1

2

High-throughput

0.479

High

1306378

WWTR1
WW domain-containing transcription regulator protein 1

1

17

Small-scale

0.479

High

1306381

RPAP3
RNA polymerase II-associated protein 3

1

4

High-throughput

0.479

High

1306386

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.479

High

1306389

MYO1A
Unconventional myosin-Ia

1

15

High-throughput

0.479

High

1306390

UXT
Protein UXT

1

1

High-throughput

0.479

High

1306393

LIMA1
LIM domain and actin-binding protein 1

1

3

High-throughput

0.479

High

1306395

BAG5
BAG family molecular chaperone regulator 5

1

3

High-throughput

0.479

High

1306398

MYO6
Unconventional myosin-VI

1

8

High-throughput

0.479

High

1306401

CHIP
E3 ubiquitin-protein ligase CHIP

1

9

High-throughput

0.479

High

1306402

Q9UQC1
Heat shock protein 72

1

15

High-throughput

0.479

High

1306403

RUVB2
RuvB-like 2

1

3

High-throughput

0.479

High

1306404

RUVB1
RuvB-like 1

1

3

High-throughput

0.479

High

1306405

NUDC
Nuclear migration protein nudC

1

2

High-throughput

0.479

High

1306406

COF2
Cofilin-2

1

1

High-throughput

0.479

High

1306408

SGT1
Protein SGT1 homolog

1

6

High-throughput

0.479

High

1306409

CBY1
Protein chibby homolog 1

1

2

High-throughput

0.479

High

1306411

NEMO
NF-kappa-B essential modulator

1

15

High-throughput

0.479

High

1306412

SCIN
Scinderin

1

2

High-throughput

0.479

High

171668

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.458

High

246029

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.458

High

506262

PYGM
Glycogen phosphorylase, muscle form

1

0

High-throughput

0.458

High

815018

LEG7
Galectin-7

1

0

High-throughput

0.458

High

901731

PFD3
Prefoldin subunit 3

1

0

High-throughput

0.458

High

1061573

CUL7
Cullin-7

1

0

High-throughput

0.458

High

1230519

CCAR2
Cell cycle and apoptosis regulator protein 2

1

0

High-throughput

0.458

High

1303988

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.458

High

1306373

PDC10
Programmed cell death protein 10

1

0

Small-scale

0.458

High

1306383

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.458

High

1306397

AKP8L
A-kinase anchor protein 8-like

1

0

High-throughput

0.458

High

1306400

SUFU
Suppressor of fused homolog

1

0

Small-scale

0.458

High

118420

HAX1
HCLS1-associated protein X-1

1

1

High-throughput

0.437

High

215473

SCO2
Protein SCO2 homolog, mitochondrial

1

2

High-throughput

0.437

High

397486

ADT2
ADP/ATP translocase 2

1

3

High-throughput

0.437

High

518464

ADT3
ADP/ATP translocase 3

1

3

High-throughput

0.437

High

794095

MATR3
Matrin-3

1

3

High-throughput

0.437

High

917813

H4
Histone H4

1

3

High-throughput

0.437

High

972807

PLOD1
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

1

1

High-throughput

0.437

High

1050040

SCRIB
Protein scribble homolog

1

3

High-throughput

0.437

High

1114339

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

5

High-throughput

0.437

High

1251609

SMRC2
SWI/SNF complex subunit SMARCC2

1

4

High-throughput

0.437

High

1306387

TMOD3
Tropomodulin-3

1

1

High-throughput

0.437

High

1306396

COR1C
Coronin-1C

1

4

High-throughput

0.437

High

1297304

Q96LM8
Dynein axonemal assembly factor 10

1

0

High-throughput

0.249

Low

1306380

CPVL
Probable serine carboxypeptidase CPVL

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024