HitPredict

Interactor 1: FGFR3 (P22607)
Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333)
Gene: FGFR3

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	9045692, 35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005794 - Golgi apparatus GO:0005886 - plasma membrane GO:0008543 - fibroblast growth factor receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 806 Hs			1 217
+	Hs
		872610 EPHB1_HUMAN (1-787): 0: 642: 18.08		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		665389 EPHA3_HUMAN (1-786): 0: 641: 20.68		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924590 EPHA7_HUMAN (1-782): 0: 626: 21.22		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Mm
		872621 EPHB2_MOUSE (1-788): 0: 624: 19.03		GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54
+	Hs
		665574 EPHB2_HUMAN (1-788): 0: 624: 19.15		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		557644 EPHB1_HUMAN (1-787): 0: 642: 18.08		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		337359 EPHA3_HUMAN (1-786): 0: 641: 20.68		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Mm
		337625 EPHA4_MOUSE (1-781): 0: 626: 20.78		ABL1_MOUSE (4-139): 4.07e-22: 95.9: 35.46
+	Hs
		789068 EPHA7_HUMAN (1-782): 0: 626: 21.22		ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04
+	Hs
		337360 EPHB2_HUMAN (1-788): 0: 624: 19.15		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		665558 EPHB2_HUMAN (1-788): 0: 624: 19.15		ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04
+	Mm
		872619 EPHB2_MOUSE (1-788): 0: 624: 19.03		ABL2_MOUSE (4-139): 1.55e-20: 91.3: 33.33
+	Hs
		412036 EPHA3_HUMAN (1-786): 0: 641: 20.68		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		433602 EPHA3_HUMAN (1-786): 0: 641: 20.68		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		522802 EPHA3_HUMAN (1-786): 0: 641: 20.68		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Mm
		763386 EPHA4_MOUSE (1-781): 0: 626: 20.78		FYN_MOUSE (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		433265 EPHB2_HUMAN (1-788): 0: 624: 19.15		YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91
+	Hs
		433772 EPHA7_HUMAN (1-782): 0: 626: 21.22		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Mm
		403425 EPHB2_MOUSE (1-788): 0: 624: 19.03		SRC_MOUSE (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		522803 EPHB2_HUMAN (1-788): 0: 624: 19.15		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58