Protein: AATC
Aspartate aminotransferase, cytoplasmic (cAspAT) (EC 2.6.1.1) (EC 2.6.1.3) (Cysteine aminotransferase, cytoplasmic) (Cysteine transaminase, cytoplasmic) (cCAT) (Glutamate oxaloacetate transaminase 1) (Transaminase A)

Gene: AATC, GOT1
Organism: Homo sapiens
Interactions: 210
UniProt ID: P17174

Gene Ontology (top 5):
GO:0004069 - L-aspartate:2-oxoglutarate aminotransferase activity
GO:0004609 - phosphatidylserine decarboxylase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

565953

AATC2
Putative aspartate aminotransferase, cytoplasmic 2

2

3

High-throughput

0.811

High

413822

GELS
Gelsolin

2

1

High-throughput

0.611

High

226453

PRKN
E3 ubiquitin-protein ligase parkin

2

3

High-throughput

0.584

High

337890

EGFR
Epidermal growth factor receptor

2

0

Small-scale

0.582

High

565908

GRB2
Growth factor receptor-bound protein 2

2

0

High-throughput

0.547

High

565891

CCR2
C-C chemokine receptor type 2

1

1

High-throughput

0.541

High

565970

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

3

High-throughput

0.541

High

82379

IGLL5
Immunoglobulin lambda-like polypeptide 5

1

8

High-throughput

0.536

High

131765

LAD1
Ladinin-1

1

2

High-throughput

0.536

High

207161

TGM5
Protein-glutamine gamma-glutamyltransferase 5

1

2

High-throughput

0.536

High

224566

AK1BA
Aldo-keto reductase family 1 member B10

1

1

High-throughput

0.536

High

234187

PEPL
Periplakin

1

4

High-throughput

0.536

High

260747

H2AY
Core histone macro-H2A.1

1

1

High-throughput

0.536

High

271850

SPB7
Serpin B7

1

8

High-throughput

0.536

High

341134

THRB
Prothrombin

1

1

High-throughput

0.536

High

341355

PLMN
Plasminogen

1

1

High-throughput

0.536

High

344272

AACT
Alpha-1-antichymotrypsin

1

7

High-throughput

0.536

High

344634

CO3
Complement C3

1

3

High-throughput

0.536

High

361310

APOA1
Apolipoprotein A-I

1

1

High-throughput

0.536

High

361737

FIBA
Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]

1

2

High-throughput

0.536

High

361816

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

2

High-throughput

0.536

High

361974

FIBG
Fibrinogen gamma chain

1

2

High-throughput

0.536

High

364520

TRFE
Serotransferrin

1

1

High-throughput

0.536

High

364646

TRFL
Lactotransferrin

1

1

High-throughput

0.536

High

376154

ANXA1
Annexin A1

1

2

High-throughput

0.536

High

396677

S10A8
Protein S100-A8

1

5

High-throughput

0.536

High

397007

PAI2
Plasminogen activator inhibitor 2

1

8

High-throughput

0.536

High

416346

S10A9
Protein S100-A9

1

6

High-throughput

0.536

High

428553

INVO
Involucrin

1

1

High-throughput

0.536

High

469843

CO4A
Complement C4-A

1

3

High-throughput

0.536

High

473771

PA24B
Cytosolic phospholipase A2 beta

1

1

High-throughput

0.536

High

521710

CADH1
Cadherin-1

1

1

High-throughput

0.536

High

533191

PLSL
Plastin-2

1

2

High-throughput

0.536

High

533958

ANXA8
Annexin A8

1

2

High-throughput

0.536

High

546920

EZRI
Ezrin

1

1

High-throughput

0.536

High

551602

DESP
Desmoplakin

1

5

High-throughput

0.536

High

565863

LEG3
Galectin-3

1

1

High-throughput

0.536

High

565864

IL1RA
Interleukin-1 receptor antagonist protein

1

3

High-throughput

0.536

High

565866

RAB5A
Ras-related protein Rab-5A

1

1

High-throughput

0.536

High

565867

ICAL
Calpastatin

1

1

High-throughput

0.536

High

565868

FILA
Filaggrin

1

3

High-throughput

0.536

High

565871

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

2

High-throughput

0.536

High

565872

S100P
Protein S100-P

1

6

High-throughput

0.536

High

565876

SPB3
Serpin B3

1

8

High-throughput

0.536

High

565880

CLIP1
CAP-Gly domain-containing linker protein 1

1

2

High-throughput

0.536

High

565881

ILEU
Leukocyte elastase inhibitor

1

8

High-throughput

0.536

High

565882

AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

1

1

High-throughput

0.536

High

565883

S10A7
Protein S100-A7

1

6

High-throughput

0.536

High

565885

1433S
14-3-3 protein sigma

1

2

High-throughput

0.536

High

565886

DSG3
Desmoglein-3

1

3

High-throughput

0.536

High

565888

SPB5
Serpin B5

1

8

High-throughput

0.536

High

565889

CAPG
Macrophage-capping protein

1

1

High-throughput

0.536

High

565895

AL1A3
Retinaldehyde dehydrogenase 3

1

1

High-throughput

0.536

High

565896

LEG7
Galectin-7

1

1

High-throughput

0.536

High

565898

SPB4
Serpin B4

1

8

High-throughput

0.536

High

565900

SPB8
Serpin B8

1

8

High-throughput

0.536

High

565902

AK1C2
Aldo-keto reductase family 1 member C2

1

1

High-throughput

0.536

High

565904

RAB25
Ras-related protein Rab-25

1

1

High-throughput

0.536

High

565905

EPIPL
Epiplakin

1

5

High-throughput

0.536

High

565906

RAB5B
Ras-related protein Rab-5B

1

1

High-throughput

0.536

High

565909

ARF5
ADP-ribosylation factor 5

1

1

High-throughput

0.536

High

565911

DSG1
Desmoglein-1

1

3

High-throughput

0.536

High

565912

DSC2
Desmocollin-2

1

3

High-throughput

0.536

High

565916

RHG01
Rho GTPase-activating protein 1

1

1

High-throughput

0.536

High

565917

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

2

High-throughput

0.536

High

565920

PKP1
Plakophilin-1

1

2

High-throughput

0.536

High

565924

ITPR3
Inositol 1,4,5-trisphosphate receptor type 3

1

1

High-throughput

0.536

High

565927

PLEC
Plectin

1

3

High-throughput

0.536

High

565945

S1A7A
Protein S100-A7A

1

6

High-throughput

0.536

High

565951

DR9C7
Short-chain dehydrogenase/reductase family 9C member 7

1

1

High-throughput

0.536

High

565960

EVPL
Envoplakin

1

5

High-throughput

0.536

High

565963

CPNS2
Calpain small subunit 2

1

2

High-throughput

0.536

High

565978

IL36G
Interleukin-36 gamma

1

3

High-throughput

0.536

High

565980

I36RA
Interleukin-36 receptor antagonist protein

1

3

High-throughput

0.536

High

565981

ZO2
Tight junction protein ZO-2

1

1

High-throughput

0.536

High

565982

IL36A
Interleukin-36 alpha

1

3

High-throughput

0.536

High

565985

DBNL
Drebrin-like protein

1

1

High-throughput

0.536

High

565990

MACF1
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

1

4

High-throughput

0.536

High

565993

PKP3
Plakophilin-3

1

2

High-throughput

0.536

High

202587

TXNL1
Thioredoxin-like protein 1

1

1

High-throughput

0.515

High

565947

PA24D
Cytosolic phospholipase A2 delta

1

1

High-throughput

0.515

High

565975

S10AE
Protein S100-A14

1

5

High-throughput

0.515

High

120068

ST2B1
Sulfotransferase 2B1

1

0

High-throughput

0.513

High

126512

QSOX1
Sulfhydryl oxidase 1

1

0

High-throughput

0.513

High

172731

ZN185
Zinc finger protein 185

1

0

High-throughput

0.513

High

213191

SNG2
Synaptogyrin-2

1

0

High-throughput

0.513

High

213797

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.513

High

238141

PLIN3
Perilipin-3

1

0

High-throughput

0.513

High

259826

LX12B
Arachidonate 12-lipoxygenase, 12R-type

1

0

High-throughput

0.513

High

304914

DUS14
Dual specificity protein phosphatase 14

1

0

High-throughput

0.513

High

325508

CLIC3
Chloride intracellular channel protein 3

1

0

High-throughput

0.513

High

325555

EMAL2
Echinoderm microtubule-associated protein-like 2

1

0

High-throughput

0.513

High

326907

DDAH2
Putative hydrolase DDAH2

1

0

High-throughput

0.513

High

335358

NB5R3
NADH-cytochrome b5 reductase 3

1

0

High-throughput

0.513

High

363712

ALBU
Albumin

1

0

High-throughput

0.513

High

399970

ICAM1
Intercellular adhesion molecule 1

1

0

High-throughput

0.513

High

441696

CFAH
Complement factor H

1

0

High-throughput

0.513

High

447731

THIK
3-ketoacyl-CoA thiolase, peroxisomal

1

0

High-throughput

0.513

High

452201

HMOX1
Heme oxygenase 1

1

0

High-throughput

0.513

High

470259

H2A1
Histone H2A type 1

1

0

High-throughput

0.513

High

517793

NFH
Neurofilament heavy polypeptide

1

0

High-throughput

0.513

High

532838

HEM2
Delta-aminolevulinic acid dehydratase

1

0

High-throughput

0.513

High

537791

KPYM
Pyruvate kinase PKM

1

0

High-throughput

0.513

High

542174

PLAK
Junction plakoglobin

1

0

High-throughput

0.513

High

546812

PPAP
Prostatic acid phosphatase

1

0

High-throughput

0.513

High

555069

CD44
CD44 antigen

1

0

High-throughput

0.513

High

558976

H15
Histone H1.5

1

0

High-throughput

0.513

High

565865

TYPH
Thymidine phosphorylase

1

0

High-throughput

0.513

High

565869

ENDOU
Uridylate-specific endoribonuclease

1

0

High-throughput

0.513

High

565870

CD9
CD9 antigen

1

0

High-throughput

0.513

High

565873

CALL3
Calmodulin-like protein 3

1

0

High-throughput

0.513

High

565875

RABP2
Cellular retinoic acid-binding protein 2

1

0

High-throughput

0.513

High

565877

BLVRB
Flavin reductase

1

0

High-throughput

0.513

High

565878

KCY
UMP-CMP kinase

1

0

High-throughput

0.513

High

565884

CASPE
Caspase-14

1

0

High-throughput

0.513

High

565892

HUTH
Histidine ammonia-lyase

1

0

High-throughput

0.513

High

565894

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

0

High-throughput

0.513

High

565897

XDH
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase

1

0

High-throughput

0.513

High

565903

BIEA
Biliverdin reductase A

1

0

High-throughput

0.513

High

565907

RAB14
Ras-related protein Rab-14

1

0

High-throughput

0.513

High

565910

HMCS1
Hydroxymethylglutaryl-CoA synthase, cytoplasmic

1

0

High-throughput

0.513

High

565919

FCL
GDP-L-fucose synthase

1

0

High-throughput

0.513

High

565925

MVP
Major vault protein

1

0

High-throughput

0.513

High

565926

PMVK
Phosphomevalonate kinase

1

0

High-throughput

0.513

High

565929

MARE2
Microtubule-associated protein RP/EB family member 2

1

0

High-throughput

0.513

High

565934

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.513

High

565936

STEA4
Metalloreductase STEAP4

1

0

High-throughput

0.513

High

565940

SBSN
Suprabasin

1

0

High-throughput

0.513

High

565941

FA83H
Protein FAM83H

1

0

High-throughput

0.513

High

565943

FBX50
F-box only protein 50

1

0

High-throughput

0.513

High

565948

AHNK2
Protein AHNAK2

1

0

High-throughput

0.513

High

565950

RDHE2
Epidermal retinol dehydrogenase 2

1

0

High-throughput

0.513

High

565954

PI42C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

1

0

High-throughput

0.513

High

565958

NDRG1
Protein NDRG1

1

0

High-throughput

0.513

High

565962

PGM2
Phosphopentomutase

1

0

High-throughput

0.513

High

565964

GSDMA
Gasdermin-A

1

0

High-throughput

0.513

High

565965

VPS35
Vacuolar protein sorting-associated protein 35

1

0

High-throughput

0.513

High

565966

NIBA2
Protein Niban 2

1

0

High-throughput

0.513

High

565967

TREX2
Three prime repair exonuclease 2

1

0

High-throughput

0.513

High

565968

TPPP3
Tubulin polymerization-promoting protein family member 3

1

0

High-throughput

0.513

High

565972

5NT3A
Cytosolic 5'-nucleotidase 3A

1

0

High-throughput

0.513

High

565973

GAN
Gigaxonin

1

0

High-throughput

0.513

High

565974

ES8L2
Epidermal growth factor receptor kinase substrate 8-like protein 2

1

0

High-throughput

0.513

High

565976

KI13B
Kinesin-like protein KIF13B

1

0

High-throughput

0.513

High

565984

NAGK
N-acetyl-D-glucosamine kinase

1

0

High-throughput

0.513

High

565987

PSME2
Proteasome activator complex subunit 2

1

0

High-throughput

0.513

High

565988

ASC
Apoptosis-associated speck-like protein containing a CARD

1

0

High-throughput

0.513

High

565991

GUAD
Guanine deaminase

1

0

High-throughput

0.513

High

565992

STA10
START domain-containing protein 10

1

0

High-throughput

0.513

High

513528

PYC
Pyruvate carboxylase, mitochondrial

1

1

Small-scale

0.501

High

565879

AGTR1
Type-1 angiotensin II receptor

1

1

High-throughput

0.494

High

565913

RL6
Large ribosomal subunit protein eL6

1

0

High-throughput

0.493

High

565939

PLBL1
Phospholipase B-like 1

1

0

High-throughput

0.493

High

198393

KLK10
Kallikrein-10

1

1

High-throughput

0.489

High

565935

ANR22
Ankyrin repeat domain-containing protein 22

1

2

High-throughput

0.489

High

565946

FCSD1
F-BAR and double SH3 domains protein 1

1

1

High-throughput

0.489

High

565961

OSTF1
Osteoclast-stimulating factor 1

1

3

High-throughput

0.489

High

565979

CALL5
Calmodulin-like protein 5

1

1

High-throughput

0.489

High

565994

CRBG1
Beta/gamma crystallin domain-containing protein 1

1

1

High-throughput

0.489

High

117345

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

1

High-throughput

0.479

High

354280

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

2

High-throughput

0.479

High

551893

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

565874

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

565890

BCL6
B-cell lymphoma 6 protein

1

1

High-throughput

0.479

High

565930

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.479

High

565942

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

565949

RHG24
Rho GTPase-activating protein 24

1

1

High-throughput

0.479

High

565986

TNIK
TRAF2 and NCK-interacting protein kinase

1

1

High-throughput

0.479

High

565989

UBQL1
Ubiquilin-1

1

2

High-throughput

0.479

High

359635

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

565862

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

565901

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.458

High

565918

CUL4A
Cullin-4A

1

0

High-throughput

0.458

High

565952

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

565957

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

565959

ESR2
Estrogen receptor beta

1

0

High-throughput

0.458

High

66374

A2ML1
Alpha-2-macroglobulin-like protein 1

1

3

High-throughput

0.445

High

353493

IGKC
Immunoglobulin kappa constant

1

7

High-throughput

0.445

High

353633

IGHG1
Immunoglobulin heavy constant gamma 1

1

7

High-throughput

0.445

High

353756

IGHG2
Immunoglobulin heavy constant gamma 2

1

7

High-throughput

0.445

High

353841

IGHG3
Immunoglobulin heavy constant gamma 3

1

6

High-throughput

0.445

High

353873

IGHG4
Immunoglobulin heavy constant gamma 4

1

7

High-throughput

0.445

High

353909

IGHM
Immunoglobulin heavy constant mu

1

6

High-throughput

0.445

High

496244

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

565893

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

2

High-throughput

0.445

High

565921

DAG1
Dystroglycan 1

1

1

Small-scale

0.445

High

565932

AXA81
Annexin A8-like protein 1

1

2

High-throughput

0.445

High

72275

B3KVV6
cDNA FLJ41607 fis, clone CTONG3001370, highly similar to Homo sapiens alpha-2-macroglobulin-like 1

1

3

High-throughput

0.437

High

565887

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

565923

RBM39
RNA-binding protein 39

1

1

High-throughput

0.437

High

565931

H37
Histone H3-7

1

0

High-throughput

0.426

High

565944

TARSH
Target of Nesh-SH3

1

0

High-throughput

0.282

High

50807

NTM2F
NUT family member 2F

1

0

High-throughput

0.279

Low

245787

CATL2
Cathepsin L2

1

0

High-throughput

0.279

Low

276965

RBBP9
Serine hydrolase RBBP9

1

0

High-throughput

0.279

Low

565899

ACADV
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

565914

TNAP2
Tumor necrosis factor alpha-induced protein 2

1

0

High-throughput

0.279

Low

565915

TAP1
Antigen peptide transporter 1

1

0

High-throughput

0.279

Low

565922

TRI29
Tripartite motif-containing protein 29

1

0

High-throughput

0.279

Low

565928

CDSN
Corneodesmosin

1

0

High-throughput

0.279

Low

565933

TT39B
Tetratricopeptide repeat protein 39B

1

0

High-throughput

0.279

Low

565937

ATLA3
Atlastin-3

1

0

High-throughput

0.279

Low

565955

POF1B
Protein POF1B

1

0

High-throughput

0.279

Low

565956

TMM40
Transmembrane protein 40

1

0

High-throughput

0.279

Low

565971

ELOV4
Very long chain fatty acid elongase 4

1

0

High-throughput

0.279

Low

565977

NECP2
Adaptin ear-binding coat-associated protein 2

1

0

High-throughput

0.279

Low

565983

CBPA4
Carboxypeptidase A4

1

0

High-throughput

0.279

Low

565995

SQOR
Sulfide:quinone oxidoreductase, mitochondrial

1

0

High-throughput

0.279

Low

565938

DMKN
Dermokine

1

0

High-throughput

0.269

Low

565969

TACAN
Ion channel TACAN

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024