Interactor 1: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL
Interactor 2: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
Method score | Annotation score | Interaction score |
---|---|---|
0.96 | 1.00 | 0.983 |
The method score is based on:
Property | Details |
---|---|
Experiments | 25814554, 25784557, 29053960, 30029779, 31120930, 18996392, 17679095, 17635922, 34831026, 12874286, 10521482, 22301280, 22266821, 23744067, unassigned1126 |
Identification Methods | two hybrid, affinity chromatography technology, enzymatic study, x-ray crystallography, far western blotting, two hybrid array |
Interaction Type | direct interaction, physical association, association |
The annotation score is based on:
Property | Details |
---|---|
Interacting Pfam domains | Cbl_N~Cbl_N, Cbl_N~Cbl_N2, Cbl_N~Cbl_N3, Cbl_N2~Cbl_N2, Cbl_N2~Cbl_N3, UBA~UBA |
Common GO terms | GO:0000209 - protein polyubiquitination GO:0001784 - phosphotyrosine residue binding GO:0004842 - ubiquitin-protein transferase activity GO:0005509 - calcium ion binding GO:0005794 - Golgi apparatus and 40 others more... |
Homologous interactions | 12 |
Homologous interactions
Color coding for hit scores
Service provided by Combinatics, Japan
Last updated: 15 Jul 2024