Interactor 1: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.983

The method score is based on:

Property Details
Experiments 25814554, 25784557, 29053960, 30029779, 31120930, 18996392, 17679095, 17635922, 34831026, 12874286, 10521482, 22301280, 22266821, 23744067, unassigned1126
Identification Methods two hybrid, affinity chromatography technology, enzymatic study, x-ray crystallography, far western blotting, two hybrid array
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Cbl_N~Cbl_N, Cbl_N~Cbl_N2, Cbl_N~Cbl_N3, Cbl_N2~Cbl_N2, Cbl_N2~Cbl_N3, UBA~UBA
Common GO terms GO:0000209 - protein polyubiquitination
GO:0001784 - phosphotyrosine residue binding
GO:0004842 - ubiquitin-protein transferase activity
GO:0005509 - calcium ion binding
GO:0005794 - Golgi apparatus
and 40 others

more...

Homologous interactions 12

Homologous interactions

Color coding for hit scores

1 906
Hs

1 906
+ Hs
+ Mm
+ Hs
+ Mm
+ Mm
+ Hs
+ Hs
+ Dm
+ Hs
+ Hs
+ Hs
+ Mm

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Last updated: 15 Jul 2024