HitPredict

Interactor 1: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: CRKL (P46109)
Crk-like protein
Gene: CRKL

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 0.60 0.770

The method score is based on:

Property Details
Experiments 25814554, 10907644, 9820532, 11133830, 9590251, 12244174, 10204582, 15107835, 9851874, 9311917, 16503409, 10657627, 9988765, 9195915, 11157475, 15556646, 18835194, 24886428, 9660791, 9092574 and 18 others

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Identification Methods two hybrid, affinity chromatography technology, pull down, far western blotting, anti tag coimmunoprecipitation, two hybrid array, anti bait coimmunoprecipitation, experimental interaction detection, coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0001784 - phosphotyrosine residue binding
GO:0005829 - cytosol
GO:0007165 - signal transduction
GO:0008584 - male gonad development
GO:0030971 - receptor tyrosine kinase binding
and 1 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Last updated: 15 Jul 2024