HitPredict

Interactor 1: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: RON (Q04912)
Macrophage-stimulating protein receptor (MSP receptor) (EC 2.7.10.1) (CDw136) (Protein-tyrosine kinase 8) (p185-Ron) (CD antigen CD136) [Cleaved into: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain]
Gene: MST1R

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	16740632, 12802274, 18273061
Identification Methods	affinity chromatography technology, isothermal titration calorimetry
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 906 Hs			1 1400
+	Hs
		441432 CBL_HUMAN (1-906): 0: 917: 100.00		MET_HUMAN (1-1391): 0: 1065: 32.44
+	Mm
		554961 CBL_MOUSE (1-906): 0: 888: 91.59		MET_MOUSE (1-1362): 0: 1074: 33.78
+	Hs
		441583 CBLC_HUMAN (42-504): 0: 620: 42.07		MET_HUMAN (1-1391): 0: 1065: 32.44
+	Hs
		610314 CBL_HUMAN (1-906): 0: 917: 100.00		EPHB1_HUMAN (557-1377): 9.28e-165: 522: 17.63
+	Hs
		610244 CBL_HUMAN (1-906): 0: 917: 100.00		EPHA2_HUMAN (557-1377): 5.9e-160: 509: 16.75
+	Hs
		610245 CBL_HUMAN (1-906): 0: 917: 100.00		EPHA8_HUMAN (568-1368): 1.37e-159: 509: 17.12
+	Hs
		601457 CBL_HUMAN (1-906): 0: 917: 100.00		FGFR2_HUMAN (784-1397): 2.76e-113: 378: 23.33
+	Hs
		610366 CBL_HUMAN (1-906): 0: 917: 100.00		FAK1_HUMAN (1022-1395): 3.19e-104: 359: 30.73
+	Hs
		983599 CBLB_HUMAN (23-901): 0: 793: 46.65		FAK1_HUMAN (1022-1395): 3.19e-104: 359: 30.73
+	Hs
		610252 CBL_HUMAN (1-906): 0: 917: 100.00		UFO_HUMAN (1062-1348): 3.97e-56: 213: 40.47
+	Hs
		435537 CBL_HUMAN (1-906): 0: 917: 100.00		IGF1R_HUMAN (1072-1343): 3.56e-52: 204: 37.93
+	Hs
		610402 CBL_HUMAN (1-906): 0: 917: 100.00		FAK2_HUMAN (1075-1384): 4.28e-51: 199: 35.65
+	Hs
		433577 CBL_HUMAN (1-906): 0: 917: 100.00		LYN_HUMAN (1088-1357): 6.87e-51: 190: 39.11
+	Hs
		610276 CBL_HUMAN (1-906): 0: 917: 100.00		CSK_HUMAN (1086-1344): 9.72e-51: 188: 40.00
+	Mm
		610545 CBL_MOUSE (1-906): 0: 888: 91.59		LYN_MOUSE (1088-1357): 7.06e-51: 190: 38.75
+	Mm
		610555 CBL_MOUSE (1-906): 0: 888: 91.59		CSK_MOUSE (1086-1344): 3.99e-51: 189: 40.39
+	Hs
		1027605 CBLB_HUMAN (23-901): 0: 793: 46.65		FAK2_HUMAN (1075-1384): 4.28e-51: 199: 35.65
+	Mm
		82734 B9EKI5_MOUSE (23-901): 0: 799: 47.22		LYN_MOUSE (1088-1357): 7.06e-51: 190: 38.75
+	Mm
		782847 CBLB_MOUSE (23-901): 0: 791: 45.98		CSK_MOUSE (1086-1344): 3.99e-51: 189: 40.39
+	Hs
		434075 CBLC_HUMAN (42-504): 0: 620: 42.07		LYN_HUMAN (1088-1357): 6.87e-51: 190: 39.11