HitPredict

Interactor 1: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: DDB1 (Q16531)
DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe)
Gene: DDB1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36470425
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006511 - ubiquitin-dependent protein catabolic process GO:0006974 - DNA damage response GO:0016567 - protein ubiquitination GO:0043066 - negative regulation of apoptotic process
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 906 Hs			1 1140
+	Mm
		610592 CBL_MOUSE (1-906): 0: 888: 91.59		DDB1_MOUSE (1-1140): 0: 1422: 99.65
+	Mm
		101442 F8VPR5_MOUSE (419-840): 3.09e-10: 66.5: 7.89		DDB1_MOUSE (1-1140): 0: 1422: 99.65