HitPredict

Interactor 1: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: CSK (P41240)
Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase CYL)
Gene: CSK

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	11149930, 19380743
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 906 Hs			1 450
+	Mm
		610555 CBL_MOUSE (1-906): 0: 888: 91.59		CSK_MOUSE (1-450): 0: 543: 99.11
+	Hs
		337348 CBL_HUMAN (1-906): 0: 917: 100.00		ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83
+	Hs
		69201 CBL_HUMAN (1-906): 0: 917: 100.00		A9UF07_HUMAN (5-447): 2.25e-159: 494: 37.83
+	Hs
		412013 CBL_HUMAN (1-906): 0: 917: 100.00		FYN_HUMAN (12-442): 1.26e-170: 491: 36.77
+	Hs
		522778 CBL_HUMAN (1-906): 0: 917: 100.00		SRC_HUMAN (12-442): 8.48e-171: 491: 39.33
+	Hs
		433254 CBL_HUMAN (1-906): 0: 917: 100.00		YES_HUMAN (12-442): 5.99e-170: 490: 37.30
+	Hs
		411595 CBL_HUMAN (1-906): 0: 917: 100.00		LCK_HUMAN (5-443): 1.95e-168: 485: 38.55
+	Hs
		610281 CBL_HUMAN (1-906): 0: 917: 100.00		ABL2_HUMAN (4-443): 1.63e-160: 485: 39.33
+	Hs
		442780 CBL_HUMAN (1-906): 0: 917: 100.00		HCK_HUMAN (3-445): 6.38e-167: 481: 36.32
+	Hs
		454799 CBL_HUMAN (1-906): 0: 917: 100.00		FGR_HUMAN (12-442): 4.47e-165: 476: 38.43
+	Mm
		337618 CBL_MOUSE (1-906): 0: 888: 91.59		ABL1_MOUSE (5-447): 5.69e-165: 495: 37.83
+	Hs
		433577 CBL_HUMAN (1-906): 0: 917: 100.00		LYN_HUMAN (4-445): 3.75e-160: 463: 37.12
+	Mm
		610554 CBL_MOUSE (1-906): 0: 888: 91.59		FYN_MOUSE (12-442): 1.69e-170: 491: 36.77
+	Hs
		610303 CBL_HUMAN (1-906): 0: 917: 100.00		BLK_HUMAN (8-445): 3.88e-159: 461: 37.03
+	Mm
		403415 CBL_MOUSE (1-906): 0: 888: 91.59		SRC_MOUSE (12-442): 1.93e-169: 488: 39.55
+	Mm
		411917 CBL_MOUSE (1-906): 0: 888: 91.59		LCK_MOUSE (5-443): 1.12e-168: 485: 38.11
+	Mm
		536206 CBL_MOUSE (1-906): 0: 888: 91.59		FGR_MOUSE (12-442): 4.23e-164: 474: 37.30
+	Mm
		435877 CBL_MOUSE (1-906): 0: 888: 91.59		HCK_MOUSE (7-445): 1.22e-162: 470: 35.98
+	Mm
		610545 CBL_MOUSE (1-906): 0: 888: 91.59		LYN_MOUSE (4-445): 3.96e-160: 463: 36.90
+	Rn
		88775 D3ZV15_RAT (1-883): 0: 833: 89.00		LYN_RAT (4-445): 2.18e-160: 464: 36.90