HitPredict

Interactor 1: CBL (P22682)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: GRB2 (Q60631)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.92 0.60 0.744

The method score is based on:

Property Details
Experiments 9174058, 17372273, 21703542, 21725061, 7657591, 8635998, 27474268, 23452850
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0001784 - phosphotyrosine residue binding
GO:0005794 - Golgi apparatus
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0007165 - signal transduction
and 2 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 913
Mm

1 217
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024