Protein: ACTZ
Alpha-centractin (Centractin) (ARP1) (Actin-RPV) (Centrosome-associated actin homolog)

Gene: ACTZ, ACTR1A
Organism: Homo sapiens
Interactions: 215
UniProt ID: P61163

Gene Ontology (top 5):
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005813 - centrosome
GO:0005829 - cytosol
GO:0005869 - dynactin complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

958431

DCTN2
Dynactin subunit 2

10

6

High-throughput

0.974

High

866634

CAZA2
F-actin-capping protein subunit alpha-2

5

13

High-throughput

0.925

High

958538

DCTN4
Dynactin subunit 4

5

5

Small-scale

0.915

High

837207

ACTY
Beta-centractin

4

18

High-throughput

0.895

High

958527

ARP10
Actin-related protein 10

4

19

Small-scale

0.886

High

958438

DYHC1
Cytoplasmic dynein 1 heavy chain 1

3

7

High-throughput

0.861

High

866961

CAPZB
F-actin-capping protein subunit beta

3

5

High-throughput

0.855

High

952703

ACTB
Actin, cytoplasmic 1

3

20

High-throughput

0.847

High

958508

PDCL3
Phosducin-like protein 3

3

6

High-throughput

0.839

High

958445

MARE1
Microtubule-associated protein RP/EB family member 1

2

1

High-throughput

0.811

High

174733

SPTN2
Spectrin beta chain, non-erythrocytic 2

2

20

Small-scale

0.804

High

610598

TCPA
T-complex protein 1 subunit alpha

2

20

High-throughput

0.789

High

821285

TCPZ
T-complex protein 1 subunit zeta

2

20

High-throughput

0.789

High

881857

TCPG
T-complex protein 1 subunit gamma

2

20

High-throughput

0.789

High

899322

TCPD
T-complex protein 1 subunit delta

2

20

High-throughput

0.789

High

958416

TCPB
T-complex protein 1 subunit beta

2

20

High-throughput

0.789

High

958425

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

2

9

High-throughput

0.789

High

447728

TPM3
Tropomyosin alpha-3 chain

2

20

High-throughput

0.754

High

958413

TPM4
Tropomyosin alpha-4 chain

2

20

High-throughput

0.754

High

958542

NINL
Ninein-like protein

2

20

High-throughput

0.754

High

958437

DCTN1
Dynactin subunit 1

6

19

High-throughput

0.732

High

442282

GELS
Gelsolin

1

20

High-throughput

0.691

High

908913

NEK4
Serine/threonine-protein kinase Nek4

1

16

High-throughput

0.691

High

915054

CAZA1
F-actin-capping protein subunit alpha-1

1

13

High-throughput

0.691

High

958410

ACTA
Actin, aortic smooth muscle

1

19

High-throughput

0.691

High

958412

ACTG
Actin, cytoplasmic 2

1

19

High-throughput

0.691

High

958480

TCPW
T-complex protein 1 subunit zeta-2

1

20

High-throughput

0.691

High

958499

TCPH
T-complex protein 1 subunit eta

1

20

High-throughput

0.691

High

958414

ACTC
Actin, alpha cardiac muscle 1

1

19

High-throughput

0.665

High

958443

PLEC
Plectin

1

20

High-throughput

0.665

High

133348

DCTN6
Dynactin subunit 6

3

2

High-throughput

0.662

High

298155

DCTN3
Dynactin subunit 3

3

3

High-throughput

0.650

High

958475

BICD2
Protein bicaudal D homolog 2

3

19

Small-scale

0.650

High

563522

CFTR
Cystic fibrosis transmembrane conductance regulator

3

4

High-throughput

0.643

High

156612

DC1I1
Cytoplasmic dynein 1 intermediate chain 1

1

8

High-throughput

0.618

High

170042

AURKA
Aurora kinase A

1

7

High-throughput

0.618

High

400583

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

4

High-throughput

0.618

High

464138

TPM2
Tropomyosin beta chain

1

20

High-throughput

0.618

High

482870

TPM1
Tropomyosin alpha-1 chain

1

20

High-throughput

0.618

High

539988

BCR
Breakpoint cluster region protein

1

18

High-throughput

0.618

High

875894

TCPE
T-complex protein 1 subunit epsilon

1

20

High-throughput

0.618

High

898977

TCPQ
T-complex protein 1 subunit theta

1

20

High-throughput

0.618

High

958420

TWF1
Twinfilin-1

1

20

High-throughput

0.618

High

958428

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

1

8

High-throughput

0.618

High

958429

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

7

High-throughput

0.618

High

958430

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

7

High-throughput

0.618

High

958435

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

8

High-throughput

0.618

High

958452

TWF2
Twinfilin-2

1

20

High-throughput

0.618

High

958467

DYH10
Dynein axonemal heavy chain 10

1

7

High-throughput

0.618

High

958528

PD1L1
Programmed cell death 1 ligand 1

1

1

High-throughput

0.618

High

210544

DC1L2
Cytoplasmic dynein 1 light intermediate chain 2

2

4

High-throughput

0.611

High

329051

KLHL2
Kelch-like protein 2

2

10

High-throughput

0.611

High

958434

CUL3
Cullin-3

2

12

High-throughput

0.611

High

958545

DC1L1
Cytoplasmic dynein 1 light intermediate chain 1

2

4

High-throughput

0.611

High

958502

DCTN5
Dynactin subunit 5

2

6

High-throughput

0.601

High

241265

PRKN
E3 ubiquitin-protein ligase parkin

2

14

High-throughput

0.584

High

731150

STIP1
Stress-induced-phosphoprotein 1

2

9

High-throughput

0.584

High

830461

CCNF
Cyclin-F

2

2

High-throughput

0.584

High

958449

LARP7
La-related protein 7

2

13

High-throughput

0.584

High

958469

NIN
Ninein

2

20

High-throughput

0.584

High

958521

ANLN
Anillin

2

10

High-throughput

0.584

High

958532

HDAC6
Protein deacetylase HDAC6

2

7

Small-scale

0.584

High

958450

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

11

High-throughput

0.575

High

395797

ESR1
Estrogen receptor

2

11

High-throughput

0.571

High

631150

RAB5A
Ras-related protein Rab-5A

2

1

High-throughput

0.571

High

934371

TERA
Transitional endoplasmic reticulum ATPase

2

6

High-throughput

0.571

High

135568

DNM1L
Dynamin-1-like protein

1

2

High-throughput

0.536

High

217257

ARK72
Aflatoxin B1 aldehyde reductase member 2

1

3

High-throughput

0.536

High

270910

CLAP2
CLIP-associating protein 2

1

1

High-throughput

0.536

High

482392

F16P1
Fructose-1,6-bisphosphatase 1

1

2

High-throughput

0.536

High

529482

TAU
Microtubule-associated protein tau

1

20

High-throughput

0.536

High

720978

CLIP1
CAP-Gly domain-containing linker protein 1

1

17

High-throughput

0.536

High

729718

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.536

High

958411

DYL1
Dynein light chain 1, cytoplasmic

1

3

High-throughput

0.536

High

958415

TBB4B
Tubulin beta-4B chain

1

3

High-throughput

0.536

High

958433

CUL1
Cullin-1

1

12

High-throughput

0.536

High

958436

SCRB2
Lysosome membrane protein 2

1

2

High-throughput

0.536

High

958461

CLAP1
CLIP-associating protein 1

1

1

High-throughput

0.536

High

958483

CSN5
COP9 signalosome complex subunit 5

1

8

High-throughput

0.536

High

958494

CDC5L
Cell division cycle 5-like protein

1

2

High-throughput

0.536

High

958509

CPVL
Probable serine carboxypeptidase CPVL

1

1

High-throughput

0.536

High

958519

RIC8A
Chaperone Ric-8A

1

1

High-throughput

0.536

High

958526

MS18A
Protein Mis18-alpha

1

1

High-throughput

0.536

High

105684

APRIO
Alternative prion protein

2

3

High-throughput

0.533

High

958466

AHNK2
Protein AHNAK2

1

8

High-throughput

0.515

High

958448

INAVA
Innate immunity activator protein

1

0

High-throughput

0.513

High

958432

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.489

High

958489

MERB1
bMERB domain-containing protein 1

1

4

High-throughput

0.489

High

958493

IWS1
Protein IWS1 homolog

1

4

High-throughput

0.489

High

958504

TX101
Testis-expressed protein 101

1

3

High-throughput

0.489

High

958505

PDGFD
Platelet-derived growth factor D

1

1

High-throughput

0.489

High

958506

DB127
Beta-defensin 127

1

1

High-throughput

0.489

High

791241

SYUA
Alpha-synuclein

1

5

High-throughput

0.481

High

128908

MEN1
Menin

1

1

High-throughput

0.479

High

155745

TXND9
Thioredoxin domain-containing protein 9

1

14

High-throughput

0.479

High

182100

PFD6
Prefoldin subunit 6

1

2

High-throughput

0.479

High

215285

TXNL1
Thioredoxin-like protein 1

1

7

High-throughput

0.479

High

293469

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

315362

RECQ4
ATP-dependent DNA helicase Q4

1

8

High-throughput

0.479

High

319592

UFL1
E3 UFM1-protein ligase 1

1

4

High-throughput

0.479

High

324702

HEXI1
Protein HEXIM1

1

7

High-throughput

0.479

High

333982

SMC2
Structural maintenance of chromosomes protein 2

1

2

High-throughput

0.479

High

346623

TTC4
Tetratricopeptide repeat protein 4

1

12

High-throughput

0.479

High

411679

NTRK1
High affinity nerve growth factor receptor

1

9

High-throughput

0.479

High

507760

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

7

High-throughput

0.479

High

536874

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

629706

BTF3
Transcription factor BTF3

1

3

High-throughput

0.479

High

872137

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.479

High

898424

PPT1
Palmitoyl-protein thioesterase 1

1

2

High-throughput

0.479

High

957273

UBC12
NEDD8-conjugating enzyme Ubc12

1

3

High-throughput

0.479

High

958406

RS3A
Small ribosomal subunit protein eS1

1

1

High-throughput

0.479

High

958409

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

958417

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

4

High-throughput

0.479

High

958418

MECOM
Histone-lysine N-methyltransferase MECOM

1

5

High-throughput

0.479

High

958419

ECHP
Peroxisomal bifunctional enzyme

1

8

High-throughput

0.479

High

958422

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

4

Small-scale

0.479

High

958424

G3BP1
Ras GTPase-activating protein-binding protein 1

1

1

High-throughput

0.479

High

958426

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

958427

SQSTM
Sequestosome-1

1

5

High-throughput

0.479

High

958440

NUMA1
Nuclear mitotic apparatus protein 1

1

20

Small-scale

0.479

High

958442

TNIP1
TNFAIP3-interacting protein 1

1

20

High-throughput

0.479

High

958446

CDC37
Hsp90 co-chaperone Cdc37

1

2

High-throughput

0.479

High

958447

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

958451

VIR
Protein virilizer homolog

1

3

High-throughput

0.479

High

958454

DEN5A
DENN domain-containing protein 5A

1

1

High-throughput

0.479

High

958455

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

958456

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

958457

DEN5B
DENN domain-containing protein 5B

1

1

High-throughput

0.479

High

958458

MOB3C
MOB kinase activator 3C

1

2

High-throughput

0.479

High

958459

SSH2
Protein phosphatase Slingshot homolog 2

1

14

High-throughput

0.479

High

958462

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

5

High-throughput

0.479

High

958463

ZN598
E3 ubiquitin-protein ligase ZNF598

1

4

High-throughput

0.479

High

958465

NUDC3
NudC domain-containing protein 3

1

4

High-throughput

0.479

High

958470

ARFG2
ADP-ribosylation factor GTPase-activating protein 2

1

3

High-throughput

0.479

High

958472

TNIP2
TNFAIP3-interacting protein 2

1

2

High-throughput

0.479

High

958473

CIP2A
Protein CIP2A

1

11

High-throughput

0.479

High

958474

ALMS1
Centrosome-associated protein ALMS1

1

5

High-throughput

0.479

High

958476

RBCC1
RB1-inducible coiled-coil protein 1

1

20

High-throughput

0.479

High

958477

PP4R1
Serine/threonine-protein phosphatase 4 regulatory subunit 1

1

3

High-throughput

0.479

High

958478

NUDC2
NudC domain-containing protein 2

1

4

High-throughput

0.479

High

958479

SCFD1
Sec1 family domain-containing protein 1

1

1

High-throughput

0.479

High

958481

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

10

High-throughput

0.479

High

958485

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

3

High-throughput

0.479

High

958487

DYL2
Dynein light chain 2, cytoplasmic

1

3

High-throughput

0.479

High

958488

CI072
Guanine nucleotide exchange factor C9orf72

1

6

High-throughput

0.479

High

958495

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

1

High-throughput

0.479

High

958496

PFD5
Prefoldin subunit 5

1

1

High-throughput

0.479

High

958497

NECD
Necdin

1

6

High-throughput

0.479

High

958498

TTC1
Tetratricopeptide repeat protein 1

1

11

High-throughput

0.479

High

958501

RIOK1
Serine/threonine-protein kinase RIO1

1

3

High-throughput

0.479

High

958507

ATG5
Autophagy protein 5

1

1

High-throughput

0.479

High

958510

CA198
Uncharacterized protein C1orf198

1

1

High-throughput

0.479

High

958511

PKHA4
Pleckstrin homology domain-containing family A member 4

1

19

High-throughput

0.479

High

958512

RPAP3
RNA polymerase II-associated protein 3

1

11

High-throughput

0.479

High

958514

PRD16
Histone-lysine N-methyltransferase PRDM16

1

3

High-throughput

0.479

High

958516

VEZA
Vezatin

1

1

High-throughput

0.479

High

958517

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

5

High-throughput

0.479

High

958520

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

High-throughput

0.479

High

958523

PIHD1
PIH1 domain-containing protein 1

1

2

High-throughput

0.479

High

958525

TBA8
Tubulin alpha-8 chain

1

7

High-throughput

0.479

High

958529

RN181
E3 ubiquitin-protein ligase RNF181

1

3

High-throughput

0.479

High

958533

DUX4
Double homeobox protein 4

1

3

High-throughput

0.479

High

958534

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

958535

PFD2
Prefoldin subunit 2

1

1

High-throughput

0.479

High

958536

DS13B
Dual specificity protein phosphatase 13B

1

16

High-throughput

0.479

High

958537

HOOK1
Protein Hook homolog 1

1

20

High-throughput

0.479

High

958539

FZR1
Fizzy-related protein homolog

1

7

High-throughput

0.479

High

958541

NUDC
Nuclear migration protein nudC

1

4

High-throughput

0.479

High

958543

SGT1
Protein SGT1 homolog

1

9

High-throughput

0.479

High

958544

C170B
Centrosomal protein of 170 kDa protein B

1

8

High-throughput

0.479

High

168516

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

1

0

High-throughput

0.458

High

379981

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.458

High

926911

ATX3
Ataxin-3

1

0

High-throughput

0.458

High

958407

PFD3
Prefoldin subunit 3

1

0

High-throughput

0.458

High

958421

NFX1
Transcriptional repressor NF-X1

1

0

High-throughput

0.458

High

958484

GLMN
Glomulin

1

0

High-throughput

0.458

High

958500

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

958503

FANCJ
Fanconi anemia group J protein

1

0

High-throughput

0.458

High

958515

CYBP
Calcyclin-binding protein

1

0

High-throughput

0.458

High

958524

COMD8
COMM domain-containing protein 8

1

0

High-throughput

0.458

High

958441

NAA25
N-alpha-acetyltransferase 25, NatB auxiliary subunit

1

4

High-throughput

0.445

High

958453

PKHA7
Pleckstrin homology domain-containing family A member 7

1

13

High-throughput

0.445

High

958464

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

3

High-throughput

0.445

High

958490

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

10

High-throughput

0.445

High

958492

CK5P2
CDK5 regulatory subunit-associated protein 2

1

20

High-throughput

0.445

High

958513

LN28A
Protein lin-28 homolog A

1

4

High-throughput

0.445

High

353182

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

371624

MYC
Myc proto-oncogene protein

1

7

High-throughput

0.437

High

588363

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

695095

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.437

High

767852

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

958408

WDR5
WD repeat-containing protein 5

1

7

High-throughput

0.437

High

958423

TIF1B
Transcription intermediary factor 1-beta

1

11

High-throughput

0.437

High

958439

RBM39
RNA-binding protein 39

1

7

High-throughput

0.437

High

958460

MEPCE
7SK snRNA methylphosphate capping enzyme

1

7

High-throughput

0.437

High

958491

CIC
Protein capicua homolog

1

7

High-throughput

0.437

High

958531

DHCR7
7-dehydrocholesterol reductase

1

1

High-throughput

0.437

High

845004

EAA3
Excitatory amino acid transporter 3

1

0

High-throughput

0.426

High

880826

NRAM2
Natural resistance-associated macrophage protein 2

1

0

High-throughput

0.426

High

94303

D6R9G5
Kelch like family member 2

1

12

High-throughput

0.407

High

254922

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

4

High-throughput

0.407

High

344150

PTBP3
Polypyrimidine tract-binding protein 3

1

1

High-throughput

0.407

High

429627

JUN
Transcription factor Jun

1

4

High-throughput

0.407

High

958444

PGFRL
Platelet-derived growth factor receptor-like protein

1

1

High-throughput

0.407

High

958468

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

1

High-throughput

0.407

High

958471

MOT11
Monocarboxylate transporter 11

1

3

High-throughput

0.407

High

958482

ESR2
Estrogen receptor beta

1

11

High-throughput

0.407

High

958522

S39A9
Zinc transporter ZIP9

1

1

High-throughput

0.407

High

958540

XCT
Cystine/glutamate transporter

1

2

High-throughput

0.407

High

886700

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.373

High

244664

ZC3H1
Zinc finger C3H1 domain-containing protein

1

0

High-throughput

0.279

Low

484467

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

958486

KBP
KIF-binding protein

1

0

High-throughput

0.249

Low

958518

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.249

Low

958530

TOM7
Mitochondrial import receptor subunit TOM7 homolog

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025