HitPredict

Interactor 1: CBL (P22682)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: ITSN2 (Q9Z0R6)
Intersectin-2 (EH domain and SH3 domain regulator of endocytosis 2) (EH and SH3 domains protein 2) (SH3 domain-containing protein 1B)
Gene: ITSN2

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	27474268
Identification Methods	affinity chromatography technology
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005509 - calcium ion binding GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 913 Mm			1 1659
+	Hs
		610517 CBL_HUMAN (1-913): 0: 894: 91.05		ITSN2_HUMAN (1-1659): 0: 785: 89.51
+	Mm
		610656 CBL_MOUSE (1-913): 0: 923: 100.00		ITSN1_MOUSE (2-1656): 0: 736: 55.40
+	Hs
		610415 CBL_HUMAN (1-913): 0: 894: 91.05		ITSN1_HUMAN (2-1656): 0: 741: 55.24
+	Hs
		1027627 CBLB_HUMAN (23-908): 0: 799: 45.92		ITSN2_HUMAN (1-1659): 0: 785: 89.51
+	Hs
		1027606 CBLB_HUMAN (23-908): 0: 799: 45.92		ITSN1_HUMAN (2-1656): 0: 741: 55.24
+	Hs
		610397 CBL_HUMAN (1-913): 0: 894: 91.05		ARHG7_HUMAN (1057-1536): 2.4e-71: 258: 18.89
+	Hs
		506515 CBL_HUMAN (1-913): 0: 894: 91.05		BCR_HUMAN (741-1630): 2.03e-68: 256: 13.91
+	Hs
		1027604 CBLB_HUMAN (23-908): 0: 799: 45.92		ARHG7_HUMAN (1057-1536): 2.4e-71: 258: 18.89
+	Hs
		548639 CBL_HUMAN (1-913): 0: 894: 91.05		VAV_HUMAN (378-1079): 5.42e-28: 124: 12.01
+	Mm
		610633 CBL_MOUSE (1-913): 0: 923: 100.00		NCK1_MOUSE (948-1155): 3.76e-18: 90.5: 26.14
+	Hs
		610308 CBL_HUMAN (1-913): 0: 894: 91.05		VAV2_HUMAN (512-1144): 5.11e-20: 99: 12.25
+	Hs
		610518 CBL_HUMAN (1-913): 0: 894: 91.05		ARHGC_HUMAN (1150-1497): 8.06e-20: 99: 26.72
+	Mm
		610601 CBL_MOUSE (1-913): 0: 923: 100.00		EP15R_MOUSE (473-637): 6.55e-10: 66.2: 17.22
+	Hs
		557607 CBL_HUMAN (1-913): 0: 894: 91.05		NCK1_HUMAN (948-1155): 3.56e-18: 90.5: 26.52
+	Hs
		610520 CBL_HUMAN (1-913): 0: 894: 91.05		EP15R_HUMAN (473-637): 1.1e-10: 68.9: 18.89
+	Hs
		548699 CBLB_HUMAN (23-908): 0: 799: 45.92		VAV_HUMAN (378-1079): 5.42e-28: 124: 12.01
+	Mm
		82736 B9EKI5_MOUSE (23-908): 0: 816: 47.71		VAV2_MOUSE (512-1144): 5.37e-20: 99: 12.03
+	Mm
		82738 B9EKI5_MOUSE (23-908): 0: 816: 47.71		NCK1_MOUSE (948-1155): 3.76e-18: 90.5: 26.14
+	Hs
		855791 CBLB_HUMAN (23-908): 0: 799: 45.92		VAV2_HUMAN (512-1144): 5.11e-20: 99: 12.25
+	Hs
		557678 CBLB_HUMAN (23-908): 0: 799: 45.92		NCK1_HUMAN (948-1155): 3.56e-18: 90.5: 26.52