Protein: ITK
Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (Interleukin-2-inducible T-cell kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk)

Gene: ITK
Organism: Homo sapiens
Interactions: 58
UniProt ID: Q08881

Gene Ontology (top 5):
GO:0001819 - positive regulation of cytokine production
GO:0001865 - NK T cell differentiation
GO:0002250 - adaptive immune response
GO:0004715 - non-membrane spanning protein tyrosine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1065076

LCP2
Lymphocyte cytosolic protein 2

6

20

Small-scale

0.938

High

1065084

CDC37
Hsp90 co-chaperone Cdc37

3

13

High-throughput

0.871

High

461405

HS90A
Heat shock protein HSP 90-alpha

3

20

High-throughput

0.861

High

468303

HS90B
Heat shock protein HSP 90-beta

3

20

High-throughput

0.861

High

363183

EGFR
Epidermal growth factor receptor

3

20

High-throughput

0.843

High

619040

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

2

16

Small-scale

0.812

High

1065073

ITK
Tyrosine-protein kinase ITK/TSK

2

20

Small-scale

0.812

High

730542

1433S
14-3-3 protein sigma

2

20

High-throughput

0.789

High

410798

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

20

High-throughput

0.778

High

440516

FYN
Tyrosine-protein kinase Fyn

2

19

Small-scale

0.778

High

641583

ERBB3
Receptor tyrosine-protein kinase erbB-3

2

20

High-throughput

0.778

High

987586

GRB2
Growth factor receptor-bound protein 2

2

20

Small-scale

0.778

High

1065078

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

2

0

High-throughput

0.770

High

193263

SOCS1
Suppressor of cytokine signaling 1

2

20

Small-scale

0.768

High

1065086

HS905
Putative heat shock protein HSP 90-alpha A5

2

20

High-throughput

0.712

High

472050

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.692

High

1065081

GAB1
GRB2-associated-binding protein 1

1

20

High-throughput

0.692

High

1059809

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

4

19

Small-scale

0.679

High

557260

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.647

High

1065082

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

1065087

ABI1
Abl interactor 1

1

20

Small-scale

0.647

High

1065094

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

12

Small-scale

0.647

High

156260

G3PT
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

2

3

High-throughput

0.628

High

699719

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

20

Small-scale

0.618

High

971443

1433E
14-3-3 protein epsilon

1

5

High-throughput

0.618

High

1065083

ELOB
Elongin-B

1

1

High-throughput

0.618

High

1065088

A16L2
Protein Atg16l2

1

12

High-throughput

0.618

High

1065090

AURKB
Aurora kinase B

1

11

High-throughput

0.618

High

842644

WASP
Actin nucleation-promoting factor WAS

2

20

Small-scale

0.613

High

220369

LAT
Linker for activation of T-cells family member 1

2

4

Small-scale

0.595

High

986370

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

5

Small-scale

0.586

High

869477

TNFL6
Tumor necrosis factor ligand superfamily member 6

1

12

Small-scale

0.578

High

1065085

H90B3
Putative heat shock protein HSP 90-beta-3

1

20

High-throughput

0.575

High

910864

IMA1
Importin subunit alpha-1

1

0

Small-scale

0.561

High

1065098

NEMO
NF-kappa-B essential modulator

1

20

High-throughput

0.561

High

1065095

IBTK
Inhibitor of Bruton tyrosine kinase

1

6

Small-scale

0.553

High

770683

SPR2A
Small proline-rich protein 2A

1

4

Small-scale

0.536

High

881890

TCPG
T-complex protein 1 subunit gamma

1

20

High-throughput

0.536

High

1065079

TCOF
Treacle protein

1

15

High-throughput

0.536

High

1065092

PININ
Pinin

1

5

High-throughput

0.536

High

1065097

SRRM2
Serine/arginine repetitive matrix protein 2

1

13

High-throughput

0.536

High

541451

FGFR1
Fibroblast growth factor receptor 1

1

20

Small-scale

0.527

High

1065091

DOK1
Docking protein 1

1

20

Small-scale

0.527

High

1065075

AHNK
Neuroblast differentiation-associated protein AHNAK

1

8

High-throughput

0.515

High

651298

CBL
E3 ubiquitin-protein ligase CBL

1

20

Small-scale

0.501

High

965638

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

12

Small-scale

0.501

High

1065080

ADA15
Disintegrin and metalloproteinase domain-containing protein 15

1

20

Small-scale

0.501

High

1065093

WDCP
WD repeat and coiled-coil-containing protein

1

1

High-throughput

0.489

High

161023

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

20

Small-scale

0.479

High

222974

PRC1
Protein regulator of cytokinesis 1

1

10

High-throughput

0.479

High

445477

CD2
T-cell surface antigen CD2

1

17

Small-scale

0.479

High

775037

FUS
RNA-binding protein FUS

1

6

High-throughput

0.479

High

1065074

EP300
Histone acetyltransferase p300

1

17

Small-scale

0.479

High

1065077

G3BP1
Ras GTPase-activating protein-binding protein 1

1

7

Small-scale

0.479

High

1065089

ATAD1
Outer mitochondrial transmembrane helix translocase

1

2

High-throughput

0.479

High

1065096

STX8
Syntaxin-8

1

3

High-throughput

0.479

High

932997

SNAA
Alpha-soluble NSF attachment protein

1

0

High-throughput

0.458

High


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Last updated: 11Aug2025