Protein: PTK6
Protein-tyrosine kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK)

Gene: PTK6
Organism: Homo sapiens
Interactions: 94
UniProt ID: Q13882

Gene Ontology (top 5):
GO:0001726 - ruffle
GO:0004713 - protein tyrosine kinase activity
GO:0004715 - non-membrane spanning protein tyrosine kinase activity
GO:0005102 - signaling receptor binding
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1118402

PTK6
Protein-tyrosine kinase 6

5

19

Small-scale

0.920

High

363261

EGFR
Epidermal growth factor receptor

3

20

Small-scale

0.840

High

641596

ERBB3
Receptor tyrosine-protein kinase erbB-3

3

20

Small-scale

0.840

High

461463

HS90A
Heat shock protein HSP 90-alpha

3

20

High-throughput

0.817

High

468361

HS90B
Heat shock protein HSP 90-beta

3

20

High-throughput

0.817

High

410829

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

20

Small-scale

0.802

High

1061512

ACTN3
Alpha-actinin-3

2

9

High-throughput

0.783

High

1098883

SLAP1
Src-like-adapter

2

18

High-throughput

0.783

High

1118406

CDC37
Hsp90 co-chaperone Cdc37

2

15

High-throughput

0.767

High

1118408

ANR55
Ankyrin repeat domain-containing protein 55

2

7

High-throughput

0.700

High

472057

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.692

High

532080

KIT
Mast/stem cell growth factor receptor Kit

1

20

High-throughput

0.692

High

1106474

GAB1
GRB2-associated-binding protein 1

1

20

High-throughput

0.692

High

1118417

DDX17
Probable ATP-dependent RNA helicase DDX17

4

2

High-throughput

0.681

High

137227

EXOC5
Exocyst complex component 5

3

1

High-throughput

0.675

High

1059830

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

3

20

Small-scale

0.667

High

1118414

CCD33
Coiled-coil domain-containing protein 33

2

3

High-throughput

0.665

High

610657

TCPA
T-complex protein 1 subunit alpha

3

20

High-throughput

0.650

High

881915

TCPG
T-complex protein 1 subunit gamma

3

20

High-throughput

0.650

High

899034

TCPQ
T-complex protein 1 subunit theta

3

20

High-throughput

0.650

High

899382

TCPD
T-complex protein 1 subunit delta

3

20

High-throughput

0.650

High

1118405

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

1118410

EFHC2
EF-hand domain-containing family member C2

4

1

High-throughput

0.637

High

155662

FCHO1
F-BAR domain only protein 1

2

10

High-throughput

0.628

High

1118412

KHDR2
KH domain-containing, RNA-binding, signal transduction-associated protein 2

2

20

High-throughput

0.628

High

155941

SOCS3
Suppressor of cytokine signaling 3

1

20

Small-scale

0.618

High

578477

BRAF
Serine/threonine-protein kinase B-raf

1

20

High-throughput

0.618

High

728225

AKT1
RAC-alpha serine/threonine-protein kinase

1

20

Small-scale

0.618

High

907271

STA5B
Signal transducer and activator of transcription 5B

1

13

Small-scale

0.618

High

1005585

PITX1
Pituitary homeobox 1

2

7

High-throughput

0.606

High

1093615

MKRN3
E3 ubiquitin-protein ligase makorin-3

2

1

High-throughput

0.606

High

1097933

CBLB
E3 ubiquitin-protein ligase CBL-B

2

20

High-throughput

0.606

High

1118411

SKT
Sickle tail protein homolog

2

8

High-throughput

0.606

High

1118415

DTX3
Probable E3 ubiquitin-protein ligase DTX3

2

8

High-throughput

0.606

High

1118422

ZN341
Zinc finger protein 341

2

3

High-throughput

0.606

High

1118423

PRDM6
Putative histone-lysine N-methyltransferase PRDM6

2

3

High-throughput

0.606

High

843549

HD
Huntingtin

2

4

High-throughput

0.596

High

163432

MEIS2
Homeobox protein Meis2

2

0

High-throughput

0.580

High

1118409

H90B3
Putative heat shock protein HSP 90-beta-3

1

20

High-throughput

0.575

High

133660

WASL
Actin nucleation-promoting factor WASL

1

20

High-throughput

0.573

High

1048847

REL
Proto-oncogene c-Rel

1

5

High-throughput

0.573

High

214810

HNRPR
Heterogeneous nuclear ribonucleoprotein R

2

5

High-throughput

0.571

High

256622

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

2

12

High-throughput

0.571

High

258873

DNJA2
DnaJ homolog subfamily A member 2

2

5

High-throughput

0.571

High

289531

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

2

7

High-throughput

0.571

High

415554

HSPB1
Heat shock protein beta-1

2

7

High-throughput

0.571

High

457427

TBB5
Tubulin beta chain

2

7

High-throughput

0.571

High

462401

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

2

13

High-throughput

0.571

High

531067

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

9

High-throughput

0.571

High

532578

CH60
60 kDa heat shock protein, mitochondrial

2

7

High-throughput

0.571

High

535043

BIP
Endoplasmic reticulum chaperone BiP

2

20

High-throughput

0.571

High

537131

HSP7C
Heat shock cognate 71 kDa protein

2

13

High-throughput

0.571

High

600810

HSP76
Heat shock 70 kDa protein 6

2

13

High-throughput

0.571

High

608593

DDX5
Probable ATP-dependent RNA helicase DDX5

2

2

High-throughput

0.571

High

665432

EF1B
Elongation factor 1-beta

2

1

High-throughput

0.571

High

724748

METK2
S-adenosylmethionine synthase isoform type-2

2

2

High-throughput

0.571

High

727800

DNJA1
DnaJ homolog subfamily A member 1

2

5

High-throughput

0.571

High

801311

HSPA9
Stress-70 protein, mitochondrial

2

20

High-throughput

0.571

High

821345

TCPZ
T-complex protein 1 subunit zeta

2

20

High-throughput

0.571

High

875955

TCPE
T-complex protein 1 subunit epsilon

2

20

High-throughput

0.571

High

910505

HNRPM
Heterogeneous nuclear ribonucleoprotein M

2

4

High-throughput

0.571

High

916255

TXTP
Tricarboxylate transport protein, mitochondrial

2

7

High-throughput

0.571

High

996691

TBA1B
Tubulin alpha-1B chain

2

11

High-throughput

0.571

High

996944

TBA4A
Tubulin alpha-4A chain

2

9

High-throughput

0.571

High

997329

TBB4B
Tubulin beta-4B chain

2

7

High-throughput

0.571

High

1007010

TCPB
T-complex protein 1 subunit beta

2

20

High-throughput

0.571

High

1118413

YTHD3
YTH domain-containing family protein 3

2

4

High-throughput

0.571

High

1118420

TCPH
T-complex protein 1 subunit eta

2

20

High-throughput

0.571

High

1118424

ATD3A
ATPase family AAA domain-containing protein 3A

2

6

High-throughput

0.571

High

1118425

TECR
Very-long-chain enoyl-CoA reductase

2

2

High-throughput

0.571

High

1118428

YTHD2
YTH domain-containing family protein 2

2

4

High-throughput

0.571

High

655191

SFPQ
Splicing factor, proline- and glutamine-rich

1

7

Small-scale

0.546

High

520026

ANDR
Androgen receptor

1

20

High-throughput

0.536

High

943048

STX17
Syntaxin-17

1

1

High-throughput

0.536

High

541476

FGFR1
Fibroblast growth factor receptor 1

1

20

Small-scale

0.527

High

1118419

DOK1
Docking protein 1

1

20

Small-scale

0.527

High

1118426

STAP2
Signal-transducing adaptor protein 2

1

4

Small-scale

0.527

High

168984

QCR8
Cytochrome b-c1 complex subunit 8

2

1

High-throughput

0.521

High

337725

SGPL1
Sphingosine-1-phosphate lyase 1

2

5

High-throughput

0.521

High

1105798

ADA15
Disintegrin and metalloproteinase domain-containing protein 15

1

20

Small-scale

0.515

High

1118427

IKZF3
Zinc finger protein Aiolos

1

7

High-throughput

0.515

High

422082

A4
Amyloid-beta precursor protein

1

10

High-throughput

0.501

High

1118407

HIF1A
Hypoxia-inducible factor 1-alpha

1

7

Small-scale

0.501

High

649768

SPR2E
Small proline-rich protein 2E

1

3

High-throughput

0.479

High

649786

SPR2D
Small proline-rich protein 2D

1

2

High-throughput

0.479

High

770677

SPR2B
Small proline-rich protein 2B

1

8

High-throughput

0.479

High

770684

SPR2A
Small proline-rich protein 2A

1

6

High-throughput

0.479

High

1118403

RBM39
RNA-binding protein 39

1

9

High-throughput

0.479

High

1118418

SPR2F
Small proline-rich protein 2F

1

1

High-throughput

0.479

High

1118404

GPNMB
Transmembrane glycoprotein NMB

1

0

Small-scale

0.458

High

1118421

SPR2G
Small proline-rich protein 2G

1

0

High-throughput

0.458

High

1118416

MYOZ3
Myozenin-3

2

0

High-throughput

0.316

High

325317

OR2A4
Olfactory receptor 2A4

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025