HitPredict

Interactor 1: PROZ (P22891)
Vitamin K-dependent protein Z
Gene: PROZ

Interactor 2: EGFL7 (Q9UHF1)
Epidermal growth factor-like protein 7 (EGF-like protein 7) (Multiple epidermal growth factor-like domains protein 7) (Multiple EGF-like domains protein 7) (NOTCH4-like protein) (Vascular endothelial statin) (VE-statin) (Zneu1)
Gene: EGFL7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	EGF~FXa_inhibition, FXa_inhibition~FXa_inhibition, FXa_inhibition~Trypsin
Common GO terms	GO:0005509 - calcium ion binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 400 Hs			1 273
+	Hs
		375828 PROC_HUMAN (23-399): 1.03e-87: 275: 28.87		PROS_HUMAN (43-186): 1.23e-19: 90.2: 22.50
+	Hs
		1355437 ST14_HUMAN (27-398): 1.02e-62: 217: 15.89		EGFL7_HUMAN (1-273): 1.56e-39: 140: 100.00
+	Hs
		409568 HEPS_HUMAN (149-399): 4.66e-56: 191: 21.58		EGFL7_HUMAN (1-273): 1.56e-39: 140: 100.00
+	Hs
		1053512 TM11B_HUMAN (188-398): 5.18e-66: 217: 18.39		GAS6_HUMAN (54-186): 3.87e-20: 91.8: 25.18
+	Hs
		1053544 ST14_HUMAN (27-398): 1.02e-62: 217: 15.89		GAS6_HUMAN (54-186): 3.87e-20: 91.8: 25.18
+	Hs
		296681 ST14_HUMAN (27-398): 1.02e-62: 217: 15.89		SLIT2_HUMAN (3-138): 1.42e-12: 69.5: 11.77
+	Hs
		1198216 TM11B_HUMAN (188-398): 5.18e-66: 217: 18.39		AGRE2_HUMAN (17-109): 7.55e-09: 58.3: 16.35
+	Hs
		1354456 ST14_HUMAN (27-398): 1.02e-62: 217: 15.89		FBLN5_HUMAN (13-187): 8.52e-09: 57.5: 17.46
+	Hs
		371465 KLKB1_HUMAN (148-398): 5.43e-61: 209: 21.43		NID2_HUMAN (4-190): 1.14e-09: 60.6: 14.49
+	Hs
		1355435 NOTC3_HUMAN (90-155): 1.55e-09: 62: 44.12		EGFL7_HUMAN (1-273): 1.56e-39: 140: 100.00
+	Mm
		192834 NOTC2_MOUSE (91-156): 9.96e-09: 59.7: 40.30		EGFL7_MOUSE (1-272): 1.11e-36: 133: 78.10
+	Hs
		944134 NOTC3_HUMAN (90-155): 1.55e-09: 62: 44.12		JAG1_HUMAN (66-168): 1.68e-10: 63.2: 28.57
+	Dr
		804162 Q1A5L3_DANRE (91-154): 1.36e-10: 65.5: 46.97		NOTC1_DANRE (81-166): 6.13e-09: 58.6: 23.60
+	Hs
		804372 NOTC3_HUMAN (90-155): 1.55e-09: 62: 44.12		NOTC1_HUMAN (80-168): 1.88e-09: 60.1: 21.81
+	Dm
		90684 E1JHA6_DROME (91-156): 7.69e-09: 60.1: 36.77		NOTCH_DROME (68-172): 9.27e-10: 61: 22.32
+	Dm
		422709 NOTCH_DROME (91-156): 8.07e-09: 59.7: 41.18		NOTCH_DROME (68-172): 9.27e-10: 61: 22.32
+	Dm
		422713 NOTCH_DROME (91-156): 8.07e-09: 59.7: 41.18		DL_DROME (53-168): 1.69e-09: 60.1: 25.58
+	Dr
		804161 Q1A5L2_DANRE (91-157): 4.43e-09: 60.5: 42.25		NOTC1_DANRE (81-166): 6.13e-09: 58.6: 23.60
+	Dr
		804160 Q1A5L1_DANRE (91-156): 8.46e-09: 59.7: 39.71		NOTC1_DANRE (81-166): 6.13e-09: 58.6: 23.60