HitPredict

Interactor 1: VINC (P18206)
Vinculin (Metavinculin) (MV)
Gene: VCL

Interactor 2: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	26831064, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0031625 - ubiquitin protein ligase binding GO:0032991 - protein-containing complex
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1134 Hs			1 1863
+	Hs
		773114 MYH10_HUMAN (4-1089): 1.59e-87: 313: 12.50		BRCA1_HUMAN (1-1863): 0: 1570: 100.00
+	Hs
		764265 CTNA1_HUMAN (5-862): 4.31e-62: 231: 14.56		BRCA1_HUMAN (1-1863): 0: 1570: 100.00
+	Hs
		799605 TLN1_HUMAN (33-1112): 6.03e-21: 102: 12.71		BRCA1_HUMAN (1-1863): 0: 1570: 100.00
+	Hs
		773270 MYH10_HUMAN (4-1089): 1.59e-87: 313: 12.50		TRIM6_HUMAN (10-377): 7.06e-68: 240: 13.54
+	Hs
		556952 MYH7_HUMAN (26-1046): 5.14e-77: 281: 10.70		TRIM6_HUMAN (10-377): 7.06e-68: 240: 13.54
+	Hs
		773269 MYH10_HUMAN (4-1089): 1.59e-87: 313: 12.50		TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30
+	Hs
		1420562 CTNL1_HUMAN (248-719): 1.95e-59: 220: 13.58		TRIM7_HUMAN (19-291): 1.54e-44: 172: 12.16
+	Hs
		623606 TLN1_HUMAN (33-1112): 6.03e-21: 102: 12.71		RO52_HUMAN (15-390): 5.97e-69: 243: 12.86