HitPredict

Interactor 1: COF1 (P23528)
Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)
Gene: CFL1

Interactor 2: Q549N0 (Q549N0)
Cofilin-2
Gene: CFL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	25416956
Identification Methods	two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cofilin_ADF~Cofilin_ADF
Common GO terms	GO:0015629 - actin cytoskeleton GO:0030043 - actin filament fragmentation GO:0051014 - actin filament severing GO:0051015 - actin filament binding
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 166 Hs			1 166
+	Hs
		618199 COF1_HUMAN (1-166): 4.46e-72: 215: 100.00		COF2_HUMAN (1-166): 1.38e-73: 219: 100.00
+	Hs
		1122125 Q549N0_HUMAN (1-166): 1.68e-71: 214: 80.72		Q549N0_HUMAN (1-166): 1.38e-73: 219: 100.00
+	Hs
		1377081 COF2_HUMAN (1-166): 1.68e-71: 214: 80.72		COF2_HUMAN (1-166): 1.38e-73: 219: 100.00
+	Hs
		618039 COF1_HUMAN (1-166): 4.46e-72: 215: 100.00		DEST_HUMAN (1-166): 2.97e-69: 208: 68.68
+	Hs
		894667 Q549N0_HUMAN (1-166): 1.68e-71: 214: 80.72		DEST_HUMAN (1-166): 2.97e-69: 208: 68.68
+	Hs
		894691 COF2_HUMAN (1-166): 1.68e-71: 214: 80.72		DEST_HUMAN (1-166): 2.97e-69: 208: 68.68
+	Hs
		618064 COF1_HUMAN (1-166): 4.46e-72: 215: 100.00		TWF1_HUMAN (3-156): 3.59e-33: 121: 21.66
+	Sc
		974363 COFI_YEAST (3-150): 3.71e-44: 144: 36.67		COFI_YEAST (3-150): 3.46e-44: 144: 36.67
+	Zm
		76927 B4FSW2_MAIZE (3-148): 1.38e-42: 140: 31.97		B4FSW2_MAIZE (3-148): 2.21e-42: 139: 31.97
+	Hs
		225096 GMFB_HUMAN (11-154): 3.96e-34: 118: 22.45		GMFG_HUMAN (1-153): 3.62e-31: 111: 17.95