HitPredict

Interactor 1: CDK1 (P23572)
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
Gene: CDK1

Interactor 2: Q9VHN1 (Q9VHN1)
Cyclin-dependent kinases regulatory subunit
Gene: Cks85A

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.80	0.792

Property	Details
Experiments	15575970, 22036573, 21827746, 16603075
Identification Methods	two hybrid, affinity chromatography technology, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	CKS~Pkinase
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 297 Dm			1 96
+	Hs
		625283 CDK2_HUMAN (1-293): 7.76e-161: 450: 62.80		CKS1_HUMAN (1-72): 3.79e-40: 129: 70.83
+	Hs
		625164 CDK2_HUMAN (1-293): 7.76e-161: 450: 62.80		CKS2_HUMAN (1-72): 1.1e-38: 125: 68.06
+	Dm
		618471 CDK2_DROME (1-291): 4.39e-134: 383: 56.70		Q9VHN1_DROME (1-96): 1.42e-58: 176: 100.00
+	Hs
		895413 CDK3_HUMAN (1-289): 1.07e-151: 428: 65.40		CKS1_HUMAN (1-72): 3.79e-40: 129: 70.83
+	Hs
		706796 CDK3_HUMAN (1-289): 1.07e-151: 428: 65.40		CKS2_HUMAN (1-72): 1.1e-38: 125: 68.06
+	Hs
		414843 CDK1_HUMAN (1-292): 1.95e-146: 414: 72.95		CKS1_HUMAN (1-72): 3.79e-40: 129: 70.83
+	Hs
		414778 CDK1_HUMAN (1-292): 1.95e-146: 414: 72.95		CKS2_HUMAN (1-72): 1.1e-38: 125: 68.06
+	Dm
		618387 CDK1_DROME (1-297): 4.79e-144: 408: 100.00		CKS1_DROME (3-73): 1.94e-39: 127: 64.79
+	At
		188136 CDKA1_ARATH (1-290): 3.16e-143: 406: 63.23		CKS1_ARATH (5-72): 6.8e-39: 126: 72.06
+	At
		621728 CDKA1_ARATH (1-290): 3.16e-143: 406: 63.23		CKS2_ARATH (5-72): 1.44e-37: 122: 67.65
+	Hs
		895414 CDK5_HUMAN (1-293): 1.86e-138: 394: 55.78		CKS1_HUMAN (1-72): 3.79e-40: 129: 70.83
+	Hs
		706797 CDK5_HUMAN (1-293): 1.86e-138: 394: 55.78		CKS2_HUMAN (1-72): 1.1e-38: 125: 68.06
+	Ce
		712291 CDK1_CAEEL (1-295): 2.78e-133: 382: 63.58		CKS1_CAEEL (3-72): 2.22e-40: 130: 61.43
+	Dm
		618437 CDK2_DROME (1-291): 4.39e-134: 383: 56.70		CKS1_DROME (3-73): 1.94e-39: 127: 64.79
+	Sp
		383445 CDK1_SCHPO (1-291): 3.51e-138: 393: 60.94		CKS1_SCHPO (4-73): 9.18e-35: 116: 46.84
+	At
		188147 CKB12_ARATH (1-294): 1.56e-132: 380: 50.80		CKS1_ARATH (5-72): 6.8e-39: 126: 72.06
+	At
		188156 CKB21_ARATH (1-295): 1.75e-131: 377: 48.19		CKS1_ARATH (5-72): 6.8e-39: 126: 72.06
+	At
		1103378 CKB12_ARATH (1-294): 1.56e-132: 380: 50.80		CKS2_ARATH (5-72): 1.44e-37: 122: 67.65
+	At
		1321299 CDKD1_ARATH (2-295): 3.92e-131: 379: 43.20		CKS2_ARATH (5-72): 1.44e-37: 122: 67.65
+	Sc
		339429 CDK1_YEAST (1-289): 9.24e-134: 382: 58.02		CKS1_YEAST (4-72): 4.21e-34: 116: 50.00