HitPredict

Interactor 1: PSA2 (P23639)
Proteasome subunit alpha type-2 (Macropain subunit Y7) (Multicatalytic endopeptidase complex subunit Y7) (Proteasome component Y7) (Proteinase YSCE subunit 7)
Gene: PRE8

Interactor 2: RPN11 (P43588)
Ubiquitin carboxyl-terminal hydrolase RPN11 (EC 3.4.19.12) (26S proteasome regulatory subunit RPN11) (Protein MPR1)
Gene: RPN11

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.753

Property	Details
Experiments	22037170, 32868373, 16284124, 22215586, 37968396, 15917626, 21321079, 21627799, 21658604, 23770819, 22927375
Identification Methods	pull down, affinity chromatography technology, biochemical
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0034515 - proteasome storage granule GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 250 Sc			1 306
+	Dm
		771306 PSA2_DROME (2-250): 2.44e-105: 306: 53.41		PSDE_DROME (1-306): 6.79e-103: 305: 64.29
+	Dm
		1278634 PSA5_DROME (3-250): 5e-93: 275: 30.59		PSDE_DROME (1-306): 6.79e-103: 305: 64.29
+	Hs
		130754 PSA5_HUMAN (3-250): 9.42e-92: 272: 30.04		PSDE_HUMAN (16-306): 2.53e-98: 293: 67.35
+	Hs
		130749 PSA4_HUMAN (1-247): 4.63e-91: 270: 34.40		PSDE_HUMAN (16-306): 2.53e-98: 293: 67.35
+	Hs
		130824 PSA6_HUMAN (2-250): 4.86e-91: 270: 32.54		PSDE_HUMAN (16-306): 2.53e-98: 293: 67.35
+	Hs
		130644 PSA7_HUMAN (1-248): 8.69e-90: 267: 32.00		PSDE_HUMAN (16-306): 2.53e-98: 293: 67.35
+	Hs
		130747 PSA2_HUMAN (1-250): 3.12e-90: 267: 56.97		PSDE_HUMAN (16-306): 2.53e-98: 293: 67.35
+	Sp
		293712 PSA2_SCHPO (1-250): 7.84e-92: 272: 66.00		RPN11_SCHPO (1-305): 3.11e-95: 285: 64.29
+	Sp
		784781 PSA5_SCHPO (3-237): 5.78e-92: 272: 31.12		RPN11_SCHPO (1-305): 3.11e-95: 285: 64.29
+	Sp
		784767 PSA3_SCHPO (1-220): 2.47e-91: 271: 33.33		RPN11_SCHPO (1-305): 3.11e-95: 285: 64.29
+	Hs
		893720 PSA6_HUMAN (2-250): 4.86e-91: 270: 32.54		CSN5_HUMAN (14-292): 7.24e-75: 234: 30.74
+	Hs
		156334 PSA7_HUMAN (1-248): 8.69e-90: 267: 32.00		CSN5_HUMAN (14-292): 7.24e-75: 234: 30.74
+	Dm
		640767 PSA2_DROME (2-250): 2.44e-105: 306: 53.41		PSMD7_DROME (23-305): 1.03e-43: 154: 15.57
+	Sc
		619520 PSA2_YEAST (1-250): 4.68e-95: 280: 100.00		RPN8_YEAST (25-305): 6.68e-51: 172: 16.03
+	Dm
		640776 PSA5_DROME (3-250): 5e-93: 275: 30.59		PSMD7_DROME (23-305): 1.03e-43: 154: 15.57
+	Sc
		619370 PSA3_YEAST (4-214): 4.62e-42: 145: 37.09		RPN11_YEAST (1-306): 4.59e-91: 274: 100.00
+	Hs
		656177 PSA5_HUMAN (3-250): 9.42e-92: 272: 30.04		PSMD7_HUMAN (23-149): 5.65e-31: 120: 24.06
+	Hs
		638089 PSA4_HUMAN (1-247): 4.63e-91: 270: 34.40		PSMD7_HUMAN (23-149): 5.65e-31: 120: 24.06
+	Hs
		849173 PSA6_HUMAN (2-250): 4.86e-91: 270: 32.54		PSMD7_HUMAN (23-149): 5.65e-31: 120: 24.06
+	Hs
		637651 PSA2_HUMAN (1-250): 3.12e-90: 267: 56.97		PSMD7_HUMAN (23-149): 5.65e-31: 120: 24.06