Protein: DSCAM
Cell adhesion molecule DSCAM (CHD2) (Down syndrome cell adhesion molecule)

Gene: DSCAM
Organism: Homo sapiens
Interactions: 160
UniProt ID: O60469

Gene Ontology (top 5):
GO:0005576 - extracellular region
GO:0005886 - plasma membrane
GO:0007155 - cell adhesion
GO:0007156 - homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007162 - negative regulation of cell adhesion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

156745

CTRO
Citron Rho-interacting kinase

1

3

High-throughput

0.698

High

208603

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

1

High-throughput

0.698

High

224556

ACTN4
Alpha-actinin-4

1

8

High-throughput

0.698

High

238790

KALRN
Kalirin

1

9

High-throughput

0.698

High

249072

FLNB
Filamin-B

1

14

High-throughput

0.698

High

249087

ACTN1
Alpha-actinin-1

1

8

High-throughput

0.698

High

249091

NCK1
SH2/SH3 adapter protein NCK1

1

7

High-throughput

0.698

High

249104

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

3

High-throughput

0.698

High

249111

LIMK1
LIM domain kinase 1

1

8

High-throughput

0.698

High

249114

AFAD
Afadin

1

20

High-throughput

0.698

High

249118

DLG4
Disks large homolog 4

1

11

High-throughput

0.698

High

249121

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

11

High-throughput

0.698

High

249122

DYST
Dystonin

1

11

High-throughput

0.698

High

249125

SOS2
Son of sevenless homolog 2

1

4

High-throughput

0.698

High

249127

MERTK
Tyrosine-protein kinase Mer

1

14

High-throughput

0.698

High

249128

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

16

High-throughput

0.698

High

249130

DLG1
Disks large homolog 1

1

11

High-throughput

0.698

High

249133

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

6

High-throughput

0.698

High

249139

PLEC
Plectin

1

10

High-throughput

0.698

High

249141

DLG2
Disks large homolog 2

1

11

High-throughput

0.698

High

249149

MAGI3
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3

1

20

High-throughput

0.698

High

249160

KI21A
Kinesin-like protein KIF21A

1

4

High-throughput

0.698

High

249164

MAGI2
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2

1

20

High-throughput

0.698

High

249170

SYNE1
Nesprin-1

1

6

High-throughput

0.698

High

249180

SEM4D
Semaphorin-4D

1

3

High-throughput

0.698

High

249185

PDLI5
PDZ and LIM domain protein 5

1

6

High-throughput

0.698

High

249189

PP16B
Protein phosphatase 1 regulatory inhibitor subunit 16B

1

8

High-throughput

0.698

High

249199

WDR13
WD repeat-containing protein 13

1

4

High-throughput

0.698

High

249204

CRAC1
Cartilage acidic protein 1

1

4

High-throughput

0.698

High

249214

MACF1
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

1

11

High-throughput

0.698

High

249220

ROBO1
Roundabout homolog 1

1

16

High-throughput

0.698

High

249080

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

0

High-throughput

0.663

High

249102

STAT3
Signal transducer and activator of transcription 3

1

0

High-throughput

0.663

High

249115

S10AA
Protein S100-A10

1

0

High-throughput

0.663

High

249143

M3K11
Mitogen-activated protein kinase kinase kinase 11

1

0

High-throughput

0.663

High

249208

SACS
Sacsin

1

0

High-throughput

0.663

High

249215

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

0

High-throughput

0.663

High

249078

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

3

High-throughput

0.625

High

249152

WDR59
GATOR2 complex protein WDR59

1

6

High-throughput

0.625

High

249171

NUP43
Nucleoporin Nup43

1

7

High-throughput

0.625

High

249172

LNX1
E3 ubiquitin-protein ligase LNX

1

20

High-throughput

0.625

High

249194

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

3

High-throughput

0.618

High

249177

PIHD2
PIH1 domain-containing protein 2

2

2

High-throughput

0.553

High

161274

ENC1
Ectoderm-neural cortex protein 1

1

2

High-throughput

0.541

High

249071

DNJA2
DnaJ homolog subfamily A member 2

1

3

High-throughput

0.541

High

249077

AP2A1
AP-2 complex subunit alpha-1

1

3

High-throughput

0.541

High

249079

APCL
Adenomatous polyposis coli protein 2

1

4

High-throughput

0.541

High

249081

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

5

High-throughput

0.541

High

249082

NFL
Neurofilament light polypeptide

1

7

High-throughput

0.541

High

249083

NFM
Neurofilament medium polypeptide

1

7

High-throughput

0.541

High

249084

VIME
Vimentin

1

7

High-throughput

0.541

High

249085

CLUS
Clusterin

1

2

High-throughput

0.541

High

249088

EF2
Elongation factor 2

1

3

High-throughput

0.541

High

249096

PAX6
Paired box protein Pax-6

1

2

High-throughput

0.541

High

249100

MERL
Merlin

1

12

High-throughput

0.541

High

249106

MAP2
Methionine aminopeptidase 2

1

1

High-throughput

0.541

High

249109

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

4

High-throughput

0.541

High

249113

SNAA
Alpha-soluble NSF attachment protein

1

1

High-throughput

0.541

High

249116

AP2B1
AP-2 complex subunit beta

1

3

High-throughput

0.541

High

249124

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

2

High-throughput

0.541

High

249126

KIF5A
Kinesin heavy chain isoform 5A

1

3

High-throughput

0.541

High

249129

BFSP1
Filensin

1

4

High-throughput

0.541

High

249138

SEPT2
Septin-2

1

1

High-throughput

0.541

High

249157

RUFY3
Protein RUFY3

1

4

High-throughput

0.541

High

249162

TTC7B
Tetratricopeptide repeat protein 7B

1

1

High-throughput

0.541

High

249179

RPGF4
Rap guanine nucleotide exchange factor 4

1

4

High-throughput

0.541

High

249182

KCNN1
Small conductance calcium-activated potassium channel protein 1

1

1

High-throughput

0.541

High

249184

BICD1
Protein bicaudal D homolog 1

1

5

High-throughput

0.541

High

249188

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

3

High-throughput

0.541

High

249198

SNAB
Beta-soluble NSF attachment protein

1

1

High-throughput

0.541

High

249202

IF122
Intraflagellar transport protein 122 homolog

1

1

High-throughput

0.541

High

249207

MTMRA
Myotubularin-related protein 10

1

1

High-throughput

0.541

High

249216

AMOL2
Angiomotin-like protein 2

1

7

High-throughput

0.541

High

49274

SHOT1
Shootin-1

1

0

High-throughput

0.518

High

155629

ASTN1
Astrotactin-1

1

0

High-throughput

0.518

High

249090

GLNA
Glutamine synthetase

1

0

High-throughput

0.518

High

249097

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.518

High

249101

CAP2
Adenylyl cyclase-associated protein 2

1

0

High-throughput

0.518

High

249105

COPD
Coatomer subunit delta

1

0

High-throughput

0.518

High

249112

IST1
IST1 homolog

1

0

High-throughput

0.518

High

249117

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.518

High

249120

CLH1
Clathrin heavy chain 1

1

0

High-throughput

0.518

High

249132

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

0

High-throughput

0.518

High

249134

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

High-throughput

0.518

High

249135

DIP2A
Disco-interacting protein 2 homolog A

1

0

High-throughput

0.518

High

249136

IMB1
Importin subunit beta-1

1

0

High-throughput

0.518

High

249137

MO4L2
Mortality factor 4-like protein 2

1

0

High-throughput

0.518

High

249142

DPYL2
Dihydropyrimidinase-related protein 2

1

0

High-throughput

0.518

High

249146

RIPL1
RILP-like protein 1

1

0

High-throughput

0.518

High

249151

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

High-throughput

0.518

High

249163

LDB1
LIM domain-binding protein 1

1

0

High-throughput

0.518

High

249175

MITD1
MIT domain-containing protein 1

1

0

High-throughput

0.518

High

249183

TTC17
Tetratricopeptide repeat protein 17

1

0

High-throughput

0.518

High

249197

XRN2
5'-3' exoribonuclease 2

1

0

High-throughput

0.518

High

249203

CPNE5
Copine-5

1

0

High-throughput

0.518

High

249209

VPS54
Vacuolar protein sorting-associated protein 54

1

0

High-throughput

0.518

High

60481

SYTC2
Threonine--tRNA ligase 2, cytoplasmic

1

1

High-throughput

0.494

High

130320

SPT5H
Transcription elongation factor SPT5

1

1

High-throughput

0.494

High

249074

TRI37
E3 ubiquitin-protein ligase TRIM37

1

13

High-throughput

0.494

High

249076

ARI2
E3 ubiquitin-protein ligase ARIH2

1

3

High-throughput

0.494

High

249086

SKIL
Ski-like protein

1

2

High-throughput

0.494

High

249089

GFAP
Glial fibrillary acidic protein

1

7

High-throughput

0.494

High

249093

ACOHC
Cytoplasmic aconitate hydratase

1

1

High-throughput

0.494

High

249095

RBTN2
Rhombotin-2

1

5

High-throughput

0.494

High

249103

ATRX
Transcriptional regulator ATRX

1

1

High-throughput

0.494

High

249107

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

2

High-throughput

0.494

High

249110

MAP11
Methionine aminopeptidase 1

1

1

High-throughput

0.494

High

249119

KRT83
Keratin, type II cuticular Hb3

1

2

High-throughput

0.494

High

249131

IFT88
Intraflagellar transport protein 88 homolog

1

2

High-throughput

0.494

High

249140

TRIPB
Thyroid receptor-interacting protein 11

1

4

High-throughput

0.494

High

249148

GASP1
G-protein coupled receptor-associated sorting protein 1

1

1

High-throughput

0.494

High

249150

MYOME
Myomegalin

1

5

High-throughput

0.494

High

249153

MPRIP
Myosin phosphatase Rho-interacting protein

1

4

High-throughput

0.494

High

249165

CUL9
Cullin-9

1

3

High-throughput

0.494

High

249167

KT222
Keratin-like protein KRT222

1

5

High-throughput

0.494

High

249168

GUF1
Translation factor GUF1, mitochondrial

1

4

High-throughput

0.494

High

249169

RCBT1
RCC1 and BTB domain-containing protein 1

1

2

High-throughput

0.494

High

249178

RUFY2
RUN and FYVE domain-containing protein 2

1

6

High-throughput

0.494

High

249181

CSN5
COP9 signalosome complex subunit 5

1

2

High-throughput

0.494

High

249186

SGSM3
Small G protein signaling modulator 3

1

1

High-throughput

0.494

High

249187

CEP63
Centrosomal protein of 63 kDa

1

7

High-throughput

0.494

High

249192

MTA3
Metastasis-associated protein MTA3

1

2

High-throughput

0.494

High

249193

KIFC3
Kinesin-like protein KIFC3

1

1

High-throughput

0.494

High

249195

KLHL4
Kelch-like protein 4

1

2

High-throughput

0.494

High

249196

BTBD1
BTB/POZ domain-containing protein 1

1

1

High-throughput

0.494

High

249206

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

2

High-throughput

0.494

High

249219

KIF3A
Kinesin-like protein KIF3A

1

3

High-throughput

0.494

High

249092

VATB2
V-type proton ATPase subunit B, brain isoform

1

3

High-throughput

0.481

High

249205

ARL8B
ADP-ribosylation factor-like protein 8B

1

5

High-throughput

0.479

High

249073

CSDE1
Cold shock domain-containing protein E1

1

0

High-throughput

0.458

High

212827

ZBT43
Zinc finger and BTB domain-containing protein 43

1

0

High-throughput

0.282

High

249075

ZN202
Zinc finger protein 202

1

0

High-throughput

0.282

High

249094

SYWC
Tryptophan--tRNA ligase, cytoplasmic

1

0

High-throughput

0.282

High

249098

METK2
S-adenosylmethionine synthase isoform type-2

1

0

High-throughput

0.282

High

249099

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

1

0

High-throughput

0.282

High

249108

MAT1
CDK-activating kinase assembly factor MAT1

1

0

High-throughput

0.282

High

249123

GFPT1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

1

0

High-throughput

0.282

High

249144

WASC4
WASH complex subunit 4

1

0

High-throughput

0.282

High

249145

GNPTA
N-acetylglucosamine-1-phosphotransferase subunits alpha/beta

1

0

High-throughput

0.282

High

249147

NOMO2
BOS complex subunit NOMO2

1

0

High-throughput

0.282

High

249156

INT8
Integrator complex subunit 8

1

0

High-throughput

0.282

High

249158

BOP
Protein Bop

1

0

High-throughput

0.282

High

249159

CXXC5
CXXC-type zinc finger protein 5

1

0

High-throughput

0.282

High

249161

CFA91
Cilia- and flagella-associated protein 91

1

0

High-throughput

0.282

High

249166

SUV3
ATP-dependent RNA helicase SUPV3L1, mitochondrial

1

0

High-throughput

0.282

High

249173

UBA3
NEDD8-activating enzyme E1 catalytic subunit

1

0

High-throughput

0.282

High

249174

COG1
Conserved oligomeric Golgi complex subunit 1

1

0

High-throughput

0.282

High

249176

STAG1
Cohesin subunit SA-1

1

0

High-throughput

0.282

High

249190

EYA3
Protein phosphatase EYA3

1

0

High-throughput

0.282

High

249191

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

0

High-throughput

0.282

High

249200

KDM4C
Lysine-specific demethylase 4C

1

0

High-throughput

0.282

High

249201

COG4
Conserved oligomeric Golgi complex subunit 4

1

0

High-throughput

0.282

High

249210

SYLC
Leucine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.282

High

249211

TFP11
Tuftelin-interacting protein 11

1

0

High-throughput

0.282

High

249212

ZBT47
Zinc finger and BTB domain-containing protein 47

1

0

High-throughput

0.282

High

249213

CAPS1
Calcium-dependent secretion activator 1

1

0

High-throughput

0.282

High

249217

PDIP2
Polymerase delta-interacting protein 2

1

0

High-throughput

0.282

High

249218

CIA2B
Cytosolic iron-sulfur assembly component 2B

1

0

High-throughput

0.282

High

249155

ZN365
Protein ZNF365

1

0

High-throughput

0.251

Low

249154

TALAN
Talanin

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025