HitPredict

Interactor 1: PSA2 (P23639)
Proteasome subunit alpha type-2 (Macropain subunit Y7) (Multicatalytic endopeptidase complex subunit Y7) (Proteasome component Y7) (Proteinase YSCE subunit 7)
Gene: PRE8

Interactor 2: PRS8 (Q01939)
26S proteasome regulatory subunit 8 homolog (Protein CIM3) (Protein SUG1) (Tat-binding protein TBY1)
Gene: RPT6

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	32868373, 37968396
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	AAA~Proteasome, AAA_lid_3~Proteasome, AAA~Proteasome_A_N, AAA_lid_3~Proteasome_A_N
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0034515 - proteasome storage granule GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 250 Sc			1 405
+	At
		286455 PSA6B_ARATH (5-250): 1.23e-106: 309: 30.52		PRS4A_ARATH (11-395): 5.61e-138: 403: 44.16
+	Rn
		566253 PSA2_RAT (1-250): 5.07e-109: 315: 56.97		PRS8_RAT (3-405): 1.36e-129: 380: 73.95
+	Dm
		186105 PSA2_DROME (2-250): 2.44e-105: 306: 53.41		PRS8_DROME (1-405): 2.81e-131: 384: 73.83
+	At
		286460 PSA5A_ARATH (4-250): 7.87e-96: 282: 33.60		PRS4A_ARATH (11-395): 5.61e-138: 403: 44.16
+	At
		1114627 PSA5B_ARATH (4-250): 2.59e-95: 280: 33.20		PRS4A_ARATH (11-395): 5.61e-138: 403: 44.16
+	At
		286458 PSA4A_ARATH (1-230): 2.61e-92: 273: 32.91		PRS4A_ARATH (11-395): 5.61e-138: 403: 44.16
+	Dm
		771327 PSA2_DROME (2-250): 2.44e-105: 306: 53.41		Q9W414_DROME (1-402): 3.17e-123: 364: 43.28
+	Dm
		771301 PSA2_DROME (2-250): 2.44e-105: 306: 53.41		Q8SZ19_DROME (1-402): 7.1e-123: 362: 43.04
+	Dm
		186129 PSA5_DROME (3-250): 5e-93: 275: 30.59		PRS8_DROME (1-405): 2.81e-131: 384: 73.83
+	Dm
		771287 PSA2_DROME (2-250): 2.44e-105: 306: 53.41		PRS4_DROME (2-395): 3.49e-118: 352: 43.40
+	Dm
		771310 PSA2_DROME (2-250): 2.44e-105: 306: 53.41		Q9V405_DROME (5-397): 1.09e-118: 352: 39.50
+	Dm
		1278655 PSA5_DROME (3-250): 5e-93: 275: 30.59		Q9W414_DROME (1-402): 3.17e-123: 364: 43.28
+	Dm
		771298 PSA2_DROME (2-250): 2.44e-105: 306: 53.41		Q7KMQ0_DROME (60-390): 1.44e-108: 327: 51.05
+	Dm
		1278638 PSA5_DROME (3-250): 5e-93: 275: 30.59		Q9V405_DROME (5-397): 1.09e-118: 352: 39.50
+	Dm
		820495 PSA5_DROME (3-250): 5e-93: 275: 30.59		PRS4_DROME (2-395): 3.49e-118: 352: 43.40
+	Hs
		656167 PSA5_HUMAN (3-250): 9.42e-92: 272: 30.04		PRS6B_HUMAN (13-397): 3.38e-118: 351: 41.04
+	Hs
		656158 PSA5_HUMAN (3-250): 9.42e-92: 272: 30.04		PRS7_HUMAN (60-390): 7.87e-110: 331: 51.05
+	Dm
		1181022 PSA5_DROME (3-250): 5e-93: 275: 30.59		Q7KMQ0_DROME (60-390): 1.44e-108: 327: 51.05
+	Sc
		619477 PSA2_YEAST (1-250): 4.68e-95: 280: 100.00		PRS4_YEAST (72-395): 3.99e-106: 321: 49.85
+	Sc
		619440 PSA2_YEAST (1-250): 4.68e-95: 280: 100.00		PRS7_YEAST (83-391): 1.16e-104: 318: 51.78