HitPredict

Interactor 1: P85B (P23726)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: PK3CA (P32871)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha) (PtdIns-3-kinase subunit p110-alpha) (p110alpha) (Phosphoinositide-3-kinase catalytic alpha polypeptide) (Serine/threonine protein kinase PIK3CA) (EC 2.7.11.1)
Gene: PIK3CA

Species: Bos taurus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.44 1.00 0.665

The method score is based on:

Property Details
Experiments 8313896
Identification Methods anti bait coimmunoprecipitation, pull down
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains PI3K_P85_iSH2~PI3_PI4_kinase, PI3K_C2~PI3K_P85_iSH2, PI3K_P85_iSH2~PI3K_p85B, PI3K_P85_iSH2~PI3Ka, PI3_PI4_kinase~SH2, PI3K_C2~SH2, PI3Ka~SH2
Common GO terms GO:0005942 - phosphatidylinositol 3-kinase complex
GO:0008286 - insulin receptor signaling pathway
GO:0043491 - phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO:0046854 - phosphatidylinositol phosphate biosynthetic process
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 724
Bt

1 1068
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024