Protein: VPP2
V-type proton ATPase 116 kDa subunit a 2 (V-ATPase 116 kDa subunit a 2) (Lysosomal H(+)-transporting ATPase V0 subunit a 2) (TJ6) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2)

Gene: VPP2, ATP6V0A2
Organism: Homo sapiens
Interactions: 159
UniProt ID: Q9Y487

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0000220 - vacuolar proton-transporting V-type ATPase, V0 domain
GO:0001669 - acrosomal vesicle
GO:0005765 - lysosomal membrane
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

961587

VA0D1
V-type proton ATPase subunit d 1

4

14

High-throughput

0.892

High

692283

VATL
V-type proton ATPase 16 kDa proteolipid subunit c

3

9

High-throughput

0.861

High

1371997

VPP1
V-type proton ATPase 116 kDa subunit a 1

3

7

High-throughput

0.855

High

637119

VATC1
V-type proton ATPase subunit C 1

3

12

High-throughput

0.839

High

784815

VATE1
V-type proton ATPase subunit E 1

3

8

High-throughput

0.839

High

1331453

VA0D2
V-type proton ATPase subunit d 2

3

14

High-throughput

0.839

High

186487

VA0E1
V-type proton ATPase subunit e 1

2

4

High-throughput

0.811

High

341226

VATG2
V-type proton ATPase subunit G 2

2

8

High-throughput

0.737

High

292787

RENR
Renin receptor

5

5

High-throughput

0.716

High

1155290

VAS1
V-type proton ATPase subunit S1

4

6

High-throughput

0.697

High

1164284

VATF
V-type proton ATPase subunit F

4

6

High-throughput

0.697

High

1106821

VPP3
V-type proton ATPase 116 kDa subunit a 3

1

7

High-throughput

0.691

High

1438151

VPP4
V-type proton ATPase 116 kDa subunit a 4

1

7

High-throughput

0.691

High

637080

VATB2
V-type proton ATPase subunit B, brain isoform

4

9

High-throughput

0.691

High

1327076

VMA12
Vacuolar ATPase assembly protein VMA12

4

6

High-throughput

0.691

High

1399188

VMA22
Vacuolar ATPase assembly protein VMA22

4

3

High-throughput

0.691

High

583122

VATB1
V-type proton ATPase subunit B, kidney isoform

4

9

High-throughput

0.683

High

590361

MUC1
Mucin-1

3

2

High-throughput

0.667

High

845872

MUC18
Cell surface glycoprotein MUC18

3

5

High-throughput

0.667

High

1402503

SERC2
Serine incorporator 2

3

1

High-throughput

0.667

High

337154

NPT2B
Sodium-dependent phosphate transport protein 2B

3

1

High-throughput

0.662

High

1491341

VATD
V-type proton ATPase subunit D

3

5

High-throughput

0.662

High

378886

CD4
T-cell surface glycoprotein CD4

2

1

High-throughput

0.628

High

878357

MRP
MARCKS-related protein

2

1

High-throughput

0.628

High

898396

BCAM
Basal cell adhesion molecule

2

5

High-throughput

0.628

High

907768

CLCN6
H(+)/Cl(-) exchange transporter 6

2

1

High-throughput

0.628

High

1212326

TM63B
Mechanosensitive cation channel TMEM63B

2

3

High-throughput

0.628

High

1333129

AT11C
Phospholipid-transporting ATPase IG

2

3

High-throughput

0.628

High

1461794

FZD10
Frizzled-10

2

1

High-throughput

0.628

High

1460181

VATH
V-type proton ATPase subunit H

1

3

High-throughput

0.618

High

380504

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

2

1

High-throughput

0.611

High

1233604

LTOR1
Ragulator complex protein LAMTOR1

2

1

Small-scale

0.611

High

127417

LEG8
Galectin-8

3

8

High-throughput

0.609

High

1191817

VMA21
Vacuolar ATPase assembly integral membrane protein VMA21

3

3

High-throughput

0.609

High

1338689

T185A
Transmembrane protein 185A

3

1

High-throughput

0.609

High

1315495

K2013
Uncharacterized protein KIAA2013

3

6

High-throughput

0.604

High

251132

B4GT3
Beta-1,4-galactosyltransferase 3

2

0

High-throughput

0.602

High

1362099

PMGT1
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

2

0

High-throughput

0.602

High

538722

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

2

3

High-throughput

0.601

High

1102814

UT1
Urea transporter 1

2

1

High-throughput

0.601

High

1404088

CYH2
Cytohesin-2

2

4

Small-scale

0.595

High

276874

VATG1
V-type proton ATPase subunit G 1

1

8

High-throughput

0.575

High

1381839

VATE2
V-type proton ATPase subunit E 2

1

8

High-throughput

0.575

High

1206042

MTUS2
Microtubule-associated tumor suppressor candidate 2

2

2

High-throughput

0.574

High

397303

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

572488

DRD2
D(2) dopamine receptor

1

1

High-throughput

0.541

High

64966

ARRD5
Arrestin domain-containing protein 5

1

1

High-throughput

0.536

High

219253

LTOR5
Ragulator complex protein LAMTOR5

1

1

High-throughput

0.536

High

269983

AUXI
Auxilin

1

1

High-throughput

0.536

High

391680

FRIH
Ferritin heavy chain

1

1

High-throughput

0.536

High

480940

LEG1
Galectin-1

1

8

High-throughput

0.536

High

932776

EMP3
Epithelial membrane protein 3

1

1

High-throughput

0.536

High

934314

AQP5
Aquaporin-5

1

4

High-throughput

0.536

High

958056

RAB14
Ras-related protein Rab-14

1

5

High-throughput

0.536

High

981387

RAB1A
Ras-related protein Rab-1A

1

4

High-throughput

0.536

High

1154793

VAMP3
Vesicle-associated membrane protein 3

1

5

High-throughput

0.536

High

1219823

PLPP4
Phospholipid phosphatase 4

1

1

High-throughput

0.536

High

1294871

STX12
Syntaxin-12

1

3

High-throughput

0.536

High

1357646

SFT2A
Vesicle transport protein SFT2A

1

1

High-throughput

0.536

High

1430494

RAB1B
Ras-related protein Rab-1B

1

2

High-throughput

0.536

High

1452048

M4A12
Membrane-spanning 4-domains subfamily A member 12

1

1

High-throughput

0.536

High

1453208

GPC5D
G-protein coupled receptor family C group 5 member D

1

1

High-throughput

0.536

High

715980

AQP1
Aquaporin-1

1

4

High-throughput

0.515

High

291735

CXB3
Gap junction beta-3 protein

1

0

High-throughput

0.513

High

291884

STK16
Serine/threonine-protein kinase 16

1

0

High-throughput

0.513

High

466069

ANXA6
Annexin A6

1

0

High-throughput

0.513

High

534340

CD8B
T-cell surface glycoprotein CD8 beta chain

1

0

High-throughput

0.513

High

536303

PPAL
Lysosomal acid phosphatase

1

0

High-throughput

0.513

High

644154

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.513

High

1041389

CAV1
Caveolin-1

1

0

High-throughput

0.513

High

1204521

XKR4
XK-related protein 4

1

0

High-throughput

0.513

High

1214389

SYT6
Synaptotagmin-6

1

0

High-throughput

0.513

High

1453150

TREM2
Triggering receptor expressed on myeloid cells 2

1

0

High-throughput

0.513

High

1454522

PCD10
Protocadherin-10

1

0

High-throughput

0.513

High

229887

EDIL3
EGF-like repeat and discoidin I-like domain-containing protein 3

1

1

High-throughput

0.489

High

630109

BTF3
Transcription factor BTF3

1

1

High-throughput

0.489

High

699286

CALX
Calnexin

1

1

High-throughput

0.489

High

1251765

CERS6
Ceramide synthase 6

1

1

High-throughput

0.489

High

1293570

F131B
Protein FAM131B

1

1

High-throughput

0.489

High

1328156

TTC9C
Tetratricopeptide repeat protein 9C

1

3

High-throughput

0.489

High

1391323

CERS2
Ceramide synthase 2

1

1

High-throughput

0.489

High

1447492

ANLN
Anillin

1

1

High-throughput

0.489

High

1450268

TYW1
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1

1

1

High-throughput

0.489

High

1460633

TBD
Tubulin delta chain

1

1

High-throughput

0.489

High

178449

NPC1
NPC intracellular cholesterol transporter 1

1

4

High-throughput

0.479

High

219004

TGON2
Trans-Golgi network integral membrane protein 2

1

3

High-throughput

0.479

High

508885

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

3

High-throughput

0.479

High

962666

RHOA
Transforming protein RhoA

1

4

High-throughput

0.479

High

989892

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

1

1

High-throughput

0.479

High

1326957

EMC5
ER membrane protein complex subunit 5

1

2

High-throughput

0.479

High

1352316

RN128
E3 ubiquitin-protein ligase RNF128

1

4

High-throughput

0.479

High

1433013

DNJC5
DnaJ homolog subfamily C member 5

1

2

High-throughput

0.479

High

1447919

SAR1A
Small COPII coat GTPase SAR1A

1

5

High-throughput

0.479

High

1460116

S12A6
Solute carrier family 12 member 6

1

5

Small-scale

0.479

High

1491342

SAR1B
Small COPII coat GTPase SAR1B

1

5

High-throughput

0.479

High

272573

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.458

High

562510

LAMP2
Lysosome-associated membrane glycoprotein 2

1

0

Small-scale

0.458

High

728497

AKT1
RAC-alpha serine/threonine-protein kinase

1

0

Small-scale

0.458

High

1163449

CAH9
Carbonic anhydrase 9

1

0

High-throughput

0.458

High

1340075

ZNRF2
E3 ubiquitin-protein ligase ZNRF2

1

0

Small-scale

0.458

High

65417

MFS2B
Sphingosine-1-phosphate transporter MFSD2B

1

3

High-throughput

0.445

High

574131

GLUT4
Solute carrier family 2, facilitated glucose transporter member 4

1

3

High-throughput

0.445

High

609849

LEG3
Galectin-3

1

8

High-throughput

0.445

High

800600

VATA
V-type proton ATPase catalytic subunit A

1

13

High-throughput

0.445

High

828586

S26A3
Chloride anion exchanger

1

3

High-throughput

0.445

High

835028

S19A1
Reduced folate transporter

1

2

High-throughput

0.445

High

912732

CTR2
Cationic amino acid transporter 2

1

5

High-throughput

0.445

High

933503

S12A2
Solute carrier family 12 member 2

1

4

High-throughput

0.445

High

1134187

NTCP
Hepatic sodium/bile acid cotransporter

1

1

High-throughput

0.445

High

1168625

SC5AC
Sodium-coupled monocarboxylate transporter 2

1

1

High-throughput

0.445

High

1238909

MFS12
Major facilitator superfamily domain-containing protein 12

1

3

High-throughput

0.445

High

1251212

ZNT10
Calcium/manganese antiporter SLC30A10

1

4

High-throughput

0.445

High

1324772

S35F6
Solute carrier family 35 member F6

1

3

High-throughput

0.445

High

1324805

LAT4
Large neutral amino acids transporter small subunit 4

1

4

High-throughput

0.445

High

1336919

VGLU3
Vesicular glutamate transporter 3

1

3

High-throughput

0.445

High

1340586

MFSD8
Major facilitator superfamily domain-containing protein 8

1

2

High-throughput

0.445

High

1353740

MOT10
Monocarboxylate transporter 10

1

7

High-throughput

0.445

High

1408092

SC6A7
Sodium-dependent proline transporter

1

4

High-throughput

0.445

High

1446226

SO1B3
Solute carrier organic anion transporter family member 1B3

1

1

High-throughput

0.445

High

1448102

S17A5
Sialin

1

3

High-throughput

0.445

High

1458330

RHCG
Ammonium transporter Rh type C

1

2

High-throughput

0.445

High

1458418

S53A1
Solute carrier family 53 member 1

1

6

High-throughput

0.445

High

1462221

S6A14
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)

1

4

High-throughput

0.445

High

1462465

FLVC2
Choline/ethanolamine transporter FLVCR2

1

5

High-throughput

0.445

High

125677

LEG9
Galectin-9

1

8

High-throughput

0.437

High

478743

HXB5
Homeobox protein Hox-B5

1

1

High-throughput

0.437

High

723150

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

1

High-throughput

0.437

High

1208119

RNFT1
E3 ubiquitin-protein ligase RNFT1

1

5

High-throughput

0.437

High

1238861

TECT3
Tectonic-3

1

1

High-throughput

0.437

High

1256234

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

1330450

EMC1
ER membrane protein complex subunit 1

1

2

High-throughput

0.437

High

1330526

RN148
RING finger protein 148

1

4

High-throughput

0.437

High

1334636

RN149
E3 ubiquitin-protein ligase RNF149

1

4

High-throughput

0.437

High

1431301

DJC25
DnaJ homolog subfamily C member 25

1

1

High-throughput

0.437

High

1348095

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

1

0

High-throughput

0.426

High

1412217

S35A5
UDP-sugar transporter protein SLC35A5

1

0

High-throughput

0.426

High

1439134

ANKH
Mineralization regulator ANKH

1

0

High-throughput

0.426

High

943563

G6PT2
Glucose-6-phosphate exchanger SLC37A1

1

4

High-throughput

0.407

High

1333428

S43A3
Equilibrative nucleobase transporter 1

1

4

High-throughput

0.407

High

1398030

MF14A
Hippocampus abundant transcript 1 protein

1

6

High-throughput

0.407

High

665754

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

2

0

High-throughput

0.328

High

1219994

SPRY7
SPRY domain-containing protein 7

2

0

High-throughput

0.328

High

1294035

ANKL2
Ankyrin repeat and LEM domain-containing protein 2

2

0

High-throughput

0.328

High

1461680

TMCC3
Transmembrane and coiled-coil domain protein 3

2

0

High-throughput

0.328

High

377335

PAHO
Pancreatic polypeptide prohormone

1

0

High-throughput

0.279

Low

548153

PSPC
Surfactant protein C

1

0

High-throughput

0.279

Low

724224

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.279

Low

1027248

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.279

Low

1200379

KCP3
Keratinocyte-associated protein 3

1

0

High-throughput

0.279

Low

1229935

STUM
Protein stum homolog

1

0

High-throughput

0.279

Low

1243109

ERIC5
Glutamate-rich protein 5

1

0

High-throughput

0.279

Low

1258848

CYS1
Cystin-1

1

0

High-throughput

0.279

Low

1365541

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

0

High-throughput

0.279

Low

1436417

PAAT
ATPase PAAT

1

0

High-throughput

0.279

Low

1491343

COX11
Cytochrome c oxidase assembly protein COX11, mitochondrial

1

0

High-throughput

0.279

Low

1450149

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

1121567

KEAP1
Kelch-like ECH-associated protein 1

1

0

High-throughput

0.232

Low

1242281

NPAL3
NIPA-like protein 3

1

0

High-throughput

0.232

Low

1254324

TMPPE
Transmembrane protein with metallophosphoesterase domain

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025