Protein: NOS2
Nitric oxide synthase, inducible (EC 1.14.13.39) (Hepatocyte NOS) (HEP-NOS) (Inducible NO synthase) (Inducible NOS) (iNOS) (NOS type II) (Peptidyl-cysteine S-nitrosylase NOS2)

Gene: NOS2
Organism: Homo sapiens
Interactions: 171
UniProt ID: P35228

Gene Ontology (top 5):
GO:0001666 - response to hypoxia
GO:0001912 - positive regulation of leukocyte mediated cytotoxicity
GO:0002227 - innate immune response in mucosa
GO:0004517 - nitric-oxide synthase activity
GO:0005516 - calmodulin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

718442

NOS2
Nitric oxide synthase, inducible

7

9

Small-scale

0.952

High

718529

SPSB2
SPRY domain-containing SOCS box protein 2

6

7

Small-scale

0.741

High

667744

NOS1
Nitric oxide synthase 1

1

9

High-throughput

0.691

High

718523

SPSB1
SPRY domain-containing SOCS box protein 1

4

7

Small-scale

0.680

High

718448

STAT1
Signal transducer and activator of transcription 1-alpha/beta

3

3

Small-scale

0.640

High

718493

TF65
Transcription factor p65

3

3

Small-scale

0.640

High

153885

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

2

6

Small-scale

0.600

High

718522

SPSB4
SPRY domain-containing SOCS box protein 4

2

7

Small-scale

0.595

High

345351

FOS
Protein c-Fos

2

3

Small-scale

0.584

High

401512

JUN
Transcription factor Jun

2

3

Small-scale

0.584

High

431587

HS90A
Heat shock protein HSP 90-alpha

2

5

Small-scale

0.584

High

718521

CUL5
Cullin-5

2

1

Small-scale

0.584

High

718541

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

2

0

Small-scale

0.576

High

545231

RAC2
Ras-related C3 botulinum toxin substrate 2

1

10

Small-scale

0.561

High

718500

RCN2
Reticulocalbin-2

1

3

High-throughput

0.553

High

718507

RCN1
Reticulocalbin-1

1

2

High-throughput

0.553

High

338024

EGFR
Epidermal growth factor receptor

1

1

Small-scale

0.534

High

718447

STAT3
Signal transducer and activator of transcription 3

1

3

Small-scale

0.534

High

718483

RAC1
Ras-related C3 botulinum toxin substrate 1

1

10

Small-scale

0.501

High

718491

CAV1
Caveolin-1

1

4

Small-scale

0.501

High

396697

S10A8
Protein S100-A8

1

1

Small-scale

0.484

High

416371

S10A9
Protein S100-A9

1

1

Small-scale

0.484

High

381825

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

Small-scale

0.479

High

121697

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

2

High-throughput

0.479

High

121949

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

1

High-throughput

0.479

High

130767

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

3

High-throughput

0.479

High

133898

DDX3X
ATP-dependent RNA helicase DDX3X

1

1

High-throughput

0.479

High

135384

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

3

High-throughput

0.479

High

153283

CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

1

1

High-throughput

0.479

High

156236

PSA7
Proteasome subunit alpha type-7

1

4

High-throughput

0.479

High

198559

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

1

High-throughput

0.479

High

243314

DNJA2
DnaJ homolog subfamily A member 2

1

2

High-throughput

0.479

High

261417

NCOR1
Nuclear receptor corepressor 1

1

2

Small-scale

0.479

High

270583

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

1

High-throughput

0.479

High

388262

HSPB1
Heat shock protein beta-1

1

1

High-throughput

0.479

High

408750

K1C18
Keratin, type I cytoskeletal 18

1

2

High-throughput

0.479

High

409018

K2C8
Keratin, type II cytoskeletal 8

1

1

High-throughput

0.479

High

437940

HS90B
Heat shock protein HSP 90-beta

1

5

High-throughput

0.479

High

472681

FBSP1
F-box/SPRY domain-containing protein 1

1

7

High-throughput

0.479

High

499573

CH60
60 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.479

High

501752

BIP
Endoplasmic reticulum chaperone BiP

1

2

High-throughput

0.479

High

524811

XRCC5
X-ray repair cross-complementing protein 5

1

1

High-throughput

0.479

High

548287

FOSL2
Fos-related antigen 2

1

1

Small-scale

0.479

High

561509

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

3

High-throughput

0.479

High

564022

HSP76
Heat shock 70 kDa protein 6

1

1

High-throughput

0.479

High

568068

JUND
Transcription factor JunD

1

3

Small-scale

0.479

High

572873

PRS6A
26S proteasome regulatory subunit 6A

1

7

High-throughput

0.479

High

573146

TCPA
T-complex protein 1 subunit alpha

1

3

High-throughput

0.479

High

584885

RO52
E3 ubiquitin-protein ligase TRIM21

1

1

High-throughput

0.479

High

587126

RXRA
Retinoic acid receptor RXR-alpha

1

3

Small-scale

0.479

High

616143

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

637335

PSA1
Proteasome subunit alpha type-1

1

4

High-throughput

0.479

High

637636

PSA2
Proteasome subunit alpha type-2

1

5

High-throughput

0.479

High

637787

PSA3
Proteasome subunit alpha type-3

1

4

High-throughput

0.479

High

638071

PSA4
Proteasome subunit alpha type-4

1

4

High-throughput

0.479

High

643432

PTBP1
Polypyrimidine tract-binding protein 1

1

1

High-throughput

0.479

High

646673

1433T
14-3-3 protein theta

1

4

High-throughput

0.479

High

656156

PSA5
Proteasome subunit alpha type-5

1

4

High-throughput

0.479

High

672012

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

1

High-throughput

0.479

High

681343

DNJA1
DnaJ homolog subfamily A member 1

1

2

High-throughput

0.479

High

684445

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

714107

HSP74
Heat shock 70 kDa protein 4

1

5

High-throughput

0.479

High

718443

PRS7
26S proteasome regulatory subunit 7

1

3

High-throughput

0.479

High

718444

PPARG
Peroxisome proliferator-activated receptor gamma

1

4

Small-scale

0.479

High

718445

GRP75
Stress-70 protein, mitochondrial

1

4

High-throughput

0.479

High

718446

TCPZ
T-complex protein 1 subunit zeta

1

3

High-throughput

0.479

High

718449

AL3B1
Aldehyde dehydrogenase family 3 member B1

1

1

High-throughput

0.479

High

718450

PRS6B
26S proteasome regulatory subunit 6B

1

4

High-throughput

0.479

High

718452

PA24A
Cytosolic phospholipase A2

1

3

Small-scale

0.479

High

718454

TCPE
T-complex protein 1 subunit epsilon

1

4

High-throughput

0.479

High

718456

TCPG
T-complex protein 1 subunit gamma

1

4

High-throughput

0.479

High

718457

EMD
Emerin

1

1

High-throughput

0.479

High

718459

TCPQ
T-complex protein 1 subunit theta

1

5

High-throughput

0.479

High

718460

TCPD
T-complex protein 1 subunit delta

1

3

High-throughput

0.479

High

718466

HSP72
Heat shock-related 70 kDa protein 2

1

1

High-throughput

0.479

High

718467

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

1

High-throughput

0.479

High

718468

TERA
Transitional endoplasmic reticulum ATPase

1

3

High-throughput

0.479

High

718470

PSA6
Proteasome subunit alpha type-6

1

5

High-throughput

0.479

High

718473

1433G
14-3-3 protein gamma

1

4

High-throughput

0.479

High

718474

PRS4
26S proteasome regulatory subunit 4

1

4

High-throughput

0.479

High

718475

PRS8
26S proteasome regulatory subunit 8

1

4

High-throughput

0.479

High

718476

1433E
14-3-3 protein epsilon

1

1

High-throughput

0.479

High

718479

PRS10
26S proteasome regulatory subunit 10B

1

4

High-throughput

0.479

High

718484

1433Z
14-3-3 protein zeta/delta

1

4

High-throughput

0.479

High

718485

SKP1
S-phase kinase-associated protein 1

1

1

High-throughput

0.479

High

718487

TCPB
T-complex protein 1 subunit beta

1

4

High-throughput

0.479

High

718488

PRKDC
DNA-dependent protein kinase catalytic subunit

1

1

High-throughput

0.479

High

718489

S25A3
Solute carrier family 25 member 3

1

1

High-throughput

0.479

High

718495

RING1
E3 ubiquitin-protein ligase RING1

1

1

Small-scale

0.479

High

718499

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

1

High-throughput

0.479

High

718502

KRT81
Keratin, type II cuticular Hb1

1

1

High-throughput

0.479

High

718503

IMB1
Importin subunit beta-1

1

1

High-throughput

0.479

High

718504

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

1

High-throughput

0.479

High

718505

PLEC
Plectin

1

1

High-throughput

0.479

High

718506

TEBP
Prostaglandin E synthase 3

1

2

High-throughput

0.479

High

718508

PCBP1
Poly(rC)-binding protein 1

1

2

High-throughput

0.479

High

718509

PCBP2
Poly(rC)-binding protein 2

1

2

High-throughput

0.479

High

718512

ELAV1
ELAV-like protein 1

1

3

Small-scale

0.479

High

718513

HERC1
Probable E3 ubiquitin-protein ligase HERC1

1

2

High-throughput

0.479

High

718517

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

1

High-throughput

0.479

High

718518

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

718519

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

1

High-throughput

0.479

High

718520

HS105
Heat shock protein 105 kDa

1

5

High-throughput

0.479

High

718524

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

2

High-throughput

0.479

High

718526

PSB7
Proteasome subunit beta type-7

1

2

High-throughput

0.479

High

718528

DNJC7
DnaJ homolog subfamily C member 7

1

2

High-throughput

0.479

High

718530

TCPH
T-complex protein 1 subunit eta

1

4

High-throughput

0.479

High

718536

CHIP
E3 ubiquitin-protein ligase CHIP

1

3

Small-scale

0.479

High

64519

ZSWM8
Zinc finger SWIM domain-containing protein 8

1

0

High-throughput

0.458

High

172366

NKRF
NF-kappa-B-repressing factor

1

0

Small-scale

0.458

High

224569

AK1BA
Aldo-keto reductase family 1 member B10

1

0

High-throughput

0.458

High

273379

PPM1B
Protein phosphatase 1B

1

0

High-throughput

0.458

High

323614

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.458

High

325059

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

0

High-throughput

0.458

High

329434

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.458

High

334351

AL1A1
Aldehyde dehydrogenase 1A1

1

0

High-throughput

0.458

High

397095

PAI1
Plasminogen activator inhibitor 1

1

0

High-throughput

0.458

High

397286

ADT2
ADP/ATP translocase 2

1

0

High-throughput

0.458

High

399989

ICAM1
Intercellular adhesion molecule 1

1

0

High-throughput

0.458

High

417983

NPM
Nucleophosmin

1

0

High-throughput

0.458

High

437280

4F2
Amino acid transporter heavy chain SLC3A2

1

0

High-throughput

0.458

High

444085

RS17
Small ribosomal subunit protein eS17

1

0

High-throughput

0.458

High

453181

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

High-throughput

0.458

High

538847

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

0

High-throughput

0.458

High

574934

RL7
Large ribosomal subunit protein uL30

1

0

High-throughput

0.458

High

607598

NDKB
Nucleoside diphosphate kinase B

1

0

High-throughput

0.458

High

653173

PYR1
Multifunctional protein CAD

1

0

High-throughput

0.458

High

718451

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.458

High

718453

PSMD8
26S proteasome non-ATPase regulatory subunit 8

1

0

High-throughput

0.458

High

718455

FAS
Fatty acid synthase

1

0

High-throughput

0.458

High

718461

FXR1
RNA-binding protein FXR1

1

0

Small-scale

0.458

High

718463

PSMD7
26S proteasome non-ATPase regulatory subunit 7

1

0

High-throughput

0.458

High

718464

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

0

High-throughput

0.458

High

718465

ICLN
Methylosome subunit pICln

1

0

High-throughput

0.458

High

718469

NP1L1
Nucleosome assembly protein 1-like 1

1

0

High-throughput

0.458

High

718471

RS3A
Small ribosomal subunit protein eS1

1

0

High-throughput

0.458

High

718477

RS18
Small ribosomal subunit protein uS13

1

0

High-throughput

0.458

High

718478

SMD3
Small nuclear ribonucleoprotein Sm D3

1

0

High-throughput

0.458

High

718480

RS4X
Small ribosomal subunit protein eS4, X isoform

1

0

High-throughput

0.458

High

718481

RL23
Large ribosomal subunit protein uL14

1

0

High-throughput

0.458

High

718482

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.458

High

718486

YBOX1
Y-box-binding protein 1

1

0

High-throughput

0.458

High

718490

LAT1
Large neutral amino acids transporter small subunit 1

1

0

High-throughput

0.458

High

718494

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

718496

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

718498

ASPH
Aspartyl/asparaginyl beta-hydroxylase

1

0

High-throughput

0.458

High

718501

FAT1
Protocadherin Fat 1

1

0

High-throughput

0.458

High

718510

ELOC
Elongin-C

1

0

Small-scale

0.458

High

718511

ELOB
Elongin-B

1

0

High-throughput

0.458

High

718514

ADRM1
Proteasomal ubiquitin receptor ADRM1

1

0

Small-scale

0.458

High

718515

SMN
Survival motor neuron protein

1

0

High-throughput

0.458

High

718516

HKDC1
Hexokinase HKDC1

1

0

High-throughput

0.458

High

718527

KLF6
Krueppel-like factor 6

1

0

Small-scale

0.458

High

718531

TBB6
Tubulin beta-6 chain

1

0

High-throughput

0.458

High

718532

COPRS
Coordinator of PRMT5 and differentiation stimulator

1

0

High-throughput

0.458

High

718535

PARP4
Protein mono-ADP-ribosyltransferase PARP4

1

0

High-throughput

0.458

High

718537

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

0

High-throughput

0.458

High

718538

DICER
Endoribonuclease Dicer

1

0

High-throughput

0.458

High

718539

RUVB2
RuvB-like 2

1

0

High-throughput

0.458

High

718540

STRAP
Serine-threonine kinase receptor-associated protein

1

0

High-throughput

0.458

High

216186

CALU
Calumenin

1

2

High-throughput

0.437

High

718497

LG3BP
Galectin-3-binding protein

1

2

High-throughput

0.437

High

718534

HACD3
Very-long-chain

1

2

High-throughput

0.437

High

718472

LYSC
Lysozyme C

1

0

Small-scale

0.426

High

718525

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

718458

PEX5
Peroxisomal targeting signal 1 receptor

1

0

Small-scale

0.391

High

718462

SSRD
Translocon-associated protein subunit delta

1

0

High-throughput

0.249

Low

718492

TNAP2
Tumor necrosis factor alpha-induced protein 2

1

0

High-throughput

0.249

Low

718533

QPCTL
Glutaminyl-peptide cyclotransferase-like protein

1

0

High-throughput

0.249

Low

718542

SQOR
Sulfide:quinone oxidoreductase, mitochondrial

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024