HitPredict - High confidence protein-protein interactions

Interactor 1: P85A (P23727)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Interactor 2: P85A (P23727)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Species: Bos taurus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	1.00	0.709

Property	Details
Experiments	19416886
Identification Methods	transmission electron microscopy, mass spectrometry study of hydrogen/deuterium exchange, nuclear magnetic resonance, atomic force microscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PI3K_P85_iSH2~PI3K_P85_iSH2, PI3K_P85_iSH2~SH2, RhoGAP~RhoGAP
Common GO terms	GO:0001678 - intracellular glucose homeostasis GO:0005068 - transmembrane receptor protein tyrosine kinase adaptor activity GO:0005158 - insulin receptor binding GO:0005159 - insulin-like growth factor receptor binding GO:0005634 - nucleus and 25 others more... GO:0005942 - phosphatidylinositol 3-kinase complex GO:0005943 - phosphatidylinositol 3-kinase complex, class IA GO:0008286 - insulin receptor signaling pathway GO:0015031 - protein transport GO:0032869 - cellular response to insulin stimulus GO:0033120 - positive regulation of RNA splicing GO:0034446 - substrate adhesion-dependent cell spreading GO:0034976 - response to endoplasmic reticulum stress GO:0035014 - phosphatidylinositol 3-kinase regulator activity GO:0042307 - positive regulation of protein import into nucleus GO:0043066 - negative regulation of apoptotic process GO:0043125 - ErbB-3 class receptor binding GO:0043491 - phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043548 - phosphatidylinositol 3-kinase binding GO:0043560 - insulin receptor substrate binding GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0046326 - positive regulation of glucose import GO:0046854 - phosphatidylinositol phosphate biosynthetic process GO:0046935 - 1-phosphatidylinositol-3-kinase regulator activity GO:0048009 - insulin-like growth factor receptor signaling pathway GO:0050821 - protein stabilization GO:0140767 - enzyme-substrate adaptor activity GO:0141038 - phosphatidylinositol 3-kinase activator activity GO:1900103 - positive regulation of endoplasmic reticulum unfolded protein response GO:1903078 - positive regulation of protein localization to plasma membrane
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1	724
Bt

1	724

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Last updated: 15 Jul 2024