Protein: KCRU
Creatine kinase U-type, mitochondrial (EC 2.7.3.2) (Acidic-type mitochondrial creatine kinase) (Mia-CK) (Ubiquitous mitochondrial creatine kinase) (U-MtCK)

Gene: KCRU, CKMT1A
Organism: Homo sapiens
Interactions: 143
UniProt ID: P12532

Gene Ontology (top 5):
GO:0004111 - creatine kinase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0046314 - phosphocreatine biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

553852

ASB9
Ankyrin repeat and SOCS box protein 9

8

6

Small-scale

0.970

High

553781

KCRS
Creatine kinase S-type, mitochondrial

4

8

High-throughput

0.892

High

445641

KCRM
Creatine kinase M-type

4

8

High-throughput

0.883

High

553108

KCRB
Creatine kinase B-type

3

8

High-throughput

0.827

High

553854

PP16A
Protein phosphatase 1 regulatory subunit 16A

2

1

High-throughput

0.700

High

553867

CLPB
Mitochondrial disaggregase

1

1

High-throughput

0.618

High

553805

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

2

1

High-throughput

0.611

High

135467

DNM1L
Dynamin-1-like protein

2

3

Small-scale

0.601

High

528965

TAU
Microtubule-associated protein tau

2

6

High-throughput

0.601

High

553782

PRS6A
26S proteasome regulatory subunit 6A

2

0

High-throughput

0.580

High

553792

RXRG
Retinoic acid receptor RXR-gamma

2

3

High-throughput

0.553

High

553800

NTF2
Nuclear transport factor 2

2

4

High-throughput

0.553

High

553871

ASB7
Ankyrin repeat and SOCS box protein 7

1

7

High-throughput

0.553

High

553799

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

0

High-throughput

0.546

High

553838

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.536

High

395396

ESR1
Estrogen receptor

2

4

High-throughput

0.521

High

553836

RHG36
Rho GTPase-activating protein 36

2

4

High-throughput

0.521

High

553779

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.513

High

156236

G3PT
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

1

1

High-throughput

0.489

High

553814

LAMB3
Laminin subunit beta-3

1

2

High-throughput

0.489

High

553822

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

2

High-throughput

0.489

High

240614

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.479

High

245412

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

4

High-throughput

0.479

High

292063

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

2

High-throughput

0.479

High

315065

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

348337

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

2

High-throughput

0.479

High

362675

EGFR
Epidermal growth factor receptor

1

2

High-throughput

0.479

High

411272

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.479

High

553778

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

1

High-throughput

0.479

High

553795

CDK7
Cyclin-dependent kinase 7

1

1

High-throughput

0.479

High

553802

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

553839

SMC5
Structural maintenance of chromosomes protein 5

1

2

High-throughput

0.479

High

553850

ESR2
Estrogen receptor beta

1

4

High-throughput

0.479

High

553856

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.479

High

553857

LMTK3
Serine/threonine-protein kinase LMTK3

1

4

High-throughput

0.479

High

553858

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.479

High

553868

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

3

High-throughput

0.479

High

553796

ITA8
Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain]

1

1

High-throughput

0.470

High

553849

KAT6B
Histone acetyltransferase KAT6B

1

1

High-throughput

0.470

High

216618

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.458

High

553808

TRAF3
TNF receptor-associated factor 3

1

0

Small-scale

0.458

High

553815

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

0

High-throughput

0.458

High

553817

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

0

High-throughput

0.458

High

553824

SURF1
Surfeit locus protein 1

1

0

High-throughput

0.458

High

553853

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

0

High-throughput

0.458

High

553859

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

0

High-throughput

0.458

High

553862

PHB2
Prohibitin-2

1

0

High-throughput

0.458

High

553864

TIM29
Mitochondrial import inner membrane translocase subunit Tim29

1

0

High-throughput

0.458

High

553866

MIC26
MICOS complex subunit MIC26

1

0

High-throughput

0.458

High

553869

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.458

High

553872

SFXN1
Sideroflexin-1

1

0

High-throughput

0.458

High

553874

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.458

High

553877

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.458

High

185392

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

2

High-throughput

0.457

High

542307

TOP2A
DNA topoisomerase 2-alpha

1

1

High-throughput

0.445

High

553804

RACK1
Small ribosomal subunit protein RACK1

1

2

High-throughput

0.445

High

553811

G3BP1
Ras GTPase-activating protein-binding protein 1

1

4

High-throughput

0.445

High

553826

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.445

High

553833

SCMC2
Mitochondrial adenyl nucleotide antiporter SLC25A25

1

2

High-throughput

0.445

High

105220

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

319350

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.437

High

324277

ARHGF
Rho guanine nucleotide exchange factor 15

1

1

High-throughput

0.437

High

405737

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.437

High

484877

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

1

High-throughput

0.437

High

553780

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

553784

CBL
E3 ubiquitin-protein ligase CBL

1

1

High-throughput

0.437

High

553785

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

553787

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

553789

MAP1B
Microtubule-associated protein 1B

1

3

High-throughput

0.437

High

553791

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.437

High

553798

CTBP2
C-terminal-binding protein 2

1

1

High-throughput

0.437

High

553803

1433Z
14-3-3 protein zeta/delta

1

1

High-throughput

0.437

High

553810

MMRN1
Multimerin-1

1

2

High-throughput

0.437

High

553812

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.437

High

553813

CUL3
Cullin-3

1

3

High-throughput

0.437

High

553816

CO4A6

1

1

High-throughput

0.437

High

553818

RBM39
RNA-binding protein 39

1

1

High-throughput

0.437

High

553819

EMC2
ER membrane protein complex subunit 2

1

3

High-throughput

0.437

High

553825

CF157
Cilia- and flagella-associated protein 157

1

1

High-throughput

0.437

High

553828

RC3H1
Roquin-1

1

3

High-throughput

0.437

High

553835

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

1

High-throughput

0.437

High

553837

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

553841

ARG39
Rho guanine nucleotide exchange factor 39

1

2

High-throughput

0.437

High

553843

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.437

High

553851

ARHGQ
Rho guanine nucleotide exchange factor 26

1

1

High-throughput

0.437

High

553863

BAG1
BAG family molecular chaperone regulator 1

1

1

High-throughput

0.437

High

553878

PD1L1
Programmed cell death 1 ligand 1

1

1

High-throughput

0.437

High

553879

HECW2
E3 ubiquitin-protein ligase HECW2

1

2

High-throughput

0.437

High

553882

FZR1
Fizzy-related protein homolog

1

3

High-throughput

0.437

High

553884

HDAC5
Histone deacetylase 5

1

2

High-throughput

0.437

High

354515

PAK4
Serine/threonine-protein kinase PAK 4

1

0

High-throughput

0.426

High

553831

RL7L
Ribosomal protein uL30-like

1

0

High-throughput

0.426

High

553860

MYCBP
c-Myc-binding protein

1

0

High-throughput

0.426

High

303398

SRP72
Signal recognition particle subunit SRP72

1

1

High-throughput

0.407

High

429213

JUN
Transcription factor Jun

1

1

High-throughput

0.407

High

479312

SRP19
Signal recognition particle 19 kDa protein

1

1

High-throughput

0.407

High

483002

CLCA
Clathrin light chain A

1

1

High-throughput

0.407

High

553783

MX1
Interferon-induced GTP-binding protein Mx1

1

4

High-throughput

0.407

High

553788

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.407

High

553790

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.407

High

553793

CTCF
Transcriptional repressor CTCF

1

1

High-throughput

0.407

High

553794

MAP2
Methionine aminopeptidase 2

1

1

High-throughput

0.407

High

553801

RS16
Small ribosomal subunit protein uS9

1

1

High-throughput

0.407

High

553830

CP135
Centrosomal protein of 135 kDa

1

1

High-throughput

0.407

High

553847

PSPC1
Paraspeckle component 1

1

2

High-throughput

0.407

High

553861

DNJC2
DnaJ homolog subfamily C member 2

1

1

High-throughput

0.407

High

553865

RBM42
RNA-binding protein 42

1

3

High-throughput

0.407

High

553880

SRP68
Signal recognition particle subunit SRP68

1

1

High-throughput

0.407

High

553883

G3BP2
Ras GTPase-activating protein-binding protein 2

1

4

High-throughput

0.407

High

553885

DRG1
Developmentally-regulated GTP-binding protein 1

1

1

High-throughput

0.407

High

506411

ONCO
Oncomodulin-1

2

0

High-throughput

0.320

High

553806

HPCA
Neuron-specific calcium-binding protein hippocalcin

2

0

High-throughput

0.316

High

553881

CTNA3
Catenin alpha-3

2

0

High-throughput

0.316

High

553832

SFRP4
Secreted frizzled-related protein 4

1

0

High-throughput

0.282

High

553809

FADD
FAS-associated death domain protein

1

0

High-throughput

0.279

Low

553840

LCORL
Ligand-dependent nuclear receptor corepressor-like protein

1

0

High-throughput

0.279

Low

553807

NPT2A
Sodium-dependent phosphate transport protein 2A

1

0

High-throughput

0.269

Low

553842

ARI2O
Uncharacterized protein ARIH2OS

1

0

High-throughput

0.269

Low

301318

WFS1
Wolframin

1

0

High-throughput

0.268

Low

553848

JPH3
Junctophilin-3

1

0

High-throughput

0.268

Low

250432

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

0

High-throughput

0.249

Low

254512

EIF1B
Eukaryotic translation initiation factor 1b

1

0

High-throughput

0.249

Low

367565

CAH2
Carbonic anhydrase 2

1

0

High-throughput

0.249

Low

379848

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.249

Low

472428

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.249

Low

538860

EPB41
Protein 4.1

1

0

High-throughput

0.249

Low

553786

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.249

Low

553797

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.249

Low

553820

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.249

Low

553821

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.249

Low

553829

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.249

Low

553834

WDR93
WD repeat-containing protein 93

1

0

High-throughput

0.249

Low

553844

FBX22
F-box only protein 22

1

0

High-throughput

0.249

Low

553845

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.249

Low

553846

DI3L1
DIS3-like exonuclease 1

1

0

High-throughput

0.249

Low

553855

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.249

Low

553870

BORG4
Cdc42 effector protein 4

1

0

High-throughput

0.249

Low

553873

CSN7B
COP9 signalosome complex subunit 7b

1

0

High-throughput

0.249

Low

553875

FANCI
Fanconi anemia group I protein

1

0

High-throughput

0.249

Low

553876

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.249

Low

406956

THY1
Thy-1 membrane glycoprotein

1

0

High-throughput

0.232

Low

553823

RBMS2
RNA-binding motif, single-stranded-interacting protein 2

1

0

High-throughput

0.232

Low

553827

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025