Protein: KCRB
Creatine kinase B-type (EC 2.7.3.2) (Brain creatine kinase) (B-CK) (Creatine kinase B chain) (Creatine phosphokinase B-type) (CPK-B)

Gene: KCRB, CKB
Organism: Homo sapiens
Interactions: 238
UniProt ID: P12277

Gene Ontology (top 5):
GO:0004111 - creatine kinase activity
GO:0005524 - ATP binding
GO:0005615 - extracellular space
GO:0005739 - mitochondrion
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

553260

ASB9
Ankyrin repeat and SOCS box protein 9

17

6

Small-scale

0.988

High

445640

KCRM
Creatine kinase M-type

5

8

High-throughput

0.922

High

553108

KCRU
Creatine kinase U-type, mitochondrial

3

8

High-throughput

0.827

High

553190

CUL3
Cullin-3

3

3

High-throughput

0.660

High

240612

PRKN
E3 ubiquitin-protein ligase parkin

3

2

High-throughput

0.640

High

553185

ILK
Scaffold protein ILK

1

0

High-throughput

0.622

High

553107

KCRB
Creatine kinase B-type

1

8

High-throughput

0.618

High

553251

ASB12
Ankyrin repeat and SOCS box protein 12

1

8

High-throughput

0.618

High

553265

ASB16
Ankyrin repeat and SOCS box protein 16

1

6

High-throughput

0.618

High

553170

NFKB2
Nuclear factor NF-kappa-B p100 subunit

1

0

High-throughput

0.586

High

361089

SODC
Superoxide dismutase [Cu-Zn]

2

0

High-throughput

0.585

High

553144

MAP1B
Microtubule-associated protein 1B

2

3

High-throughput

0.584

High

553219

HUWE1
E3 ubiquitin-protein ligase HUWE1

2

2

High-throughput

0.584

High

553233

RHG24
Rho GTPase-activating protein 24

3

3

High-throughput

0.578

High

410565

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

2

High-throughput

0.576

High

295451

PSD10
26S proteasome non-ATPase regulatory subunit 10

1

1

High-throughput

0.575

High

553125

PEBP1
Phosphatidylethanolamine-binding protein 1

2

1

High-throughput

0.571

High

553203

RHGBB
Inactive Rho GTPase-activating protein 11B

2

4

High-throughput

0.571

High

553242

DOCK8
Dedicator of cytokinesis protein 8

2

1

High-throughput

0.571

High

553138

SYUA
Alpha-synuclein

2

0

High-throughput

0.561

High

553141

CCNF
Cyclin-F

2

0

High-throughput

0.559

High

528964

TAU
Microtubule-associated protein tau

1

6

High-throughput

0.554

High

553202

ANR55
Ankyrin repeat domain-containing protein 55

1

3

High-throughput

0.553

High

334983

ARI2
E3 ubiquitin-protein ligase ARIH2

2

2

Small-scale

0.550

High

553178

SOS2
Son of sevenless homolog 2

2

0

High-throughput

0.547

High

553234

SH2D3
SH2 domain-containing protein 3C

2

0

High-throughput

0.547

High

135466

DNM1L
Dynamin-1-like protein

1

3

High-throughput

0.536

High

180682

TIF1A
Transcription intermediary factor 1-alpha

1

2

High-throughput

0.536

High

553129

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

1

High-throughput

0.536

High

553135

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

3

High-throughput

0.536

High

553145

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

2

High-throughput

0.536

High

553189

CUL1
Cullin-1

1

3

High-throughput

0.536

High

553191

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

2

High-throughput

0.536

High

553196

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

2

High-throughput

0.536

High

553127

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

0

High-throughput

0.530

High

553264

DOCK7
Dedicator of cytokinesis protein 7

2

1

High-throughput

0.521

High

463889

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

4

High-throughput

0.515

High

385404

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.513

High

484349

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

553116

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

0

High-throughput

0.513

High

553137

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.513

High

553208

USPL1
SUMO-specific isopeptidase USPL1

1

0

High-throughput

0.513

High

553245

PPTC7
Protein phosphatase PTC7 homolog

1

0

High-throughput

0.513

High

553247

PHOP1
Phosphoethanolamine/phosphocholine phosphatase

1

0

High-throughput

0.513

High

553268

ARI3A
AT-rich interactive domain-containing protein 3A

1

0

High-throughput

0.513

High

553299

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

0

High-throughput

0.513

High

553160

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

1

Small-scale

0.508

High

553199

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

1

High-throughput

0.508

High

185391

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

2

High-throughput

0.501

High

553176

UBE3A
Ubiquitin-protein ligase E3A

1

2

Small-scale

0.501

High

553255

CUL5
Cullin-5

1

3

Small-scale

0.501

High

553115

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

0

High-throughput

0.493

High

553139

MLH1
DNA mismatch repair protein Mlh1

1

0

Small-scale

0.486

High

553179

GOGA2
Golgin subfamily A member 2

1

1

Small-scale

0.481

High

73990

MYO9A
Unconventional myosin-IXa

1

1

High-throughput

0.479

High

136805

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

3

High-throughput

0.479

High

179131

ARC1B
Actin-related protein 2/3 complex subunit 1B

1

1

Small-scale

0.479

High

239697

PCDH7
Protocadherin-7

1

1

High-throughput

0.479

High

271860

OBSL1
Obscurin-like protein 1

1

1

High-throughput

0.479

High

315064

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

319349

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

338578

AGRL2
Adhesion G protein-coupled receptor L2

1

2

High-throughput

0.479

High

348336

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

2

High-throughput

0.479

High

371040

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

402501

ALDOA
Fructose-bisphosphate aldolase A

1

1

High-throughput

0.479

High

411271

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.479

High

445702

ENOA
Alpha-enolase

1

1

High-throughput

0.479

High

519696

ANDR
Androgen receptor

1

4

High-throughput

0.479

High

553110

ENPL
Endoplasmin

1

2

High-throughput

0.479

High

553112

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

553113

CXA1
Gap junction alpha-1 protein

1

1

High-throughput

0.479

High

553117

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

1

High-throughput

0.479

High

553118

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

1

High-throughput

0.479

High

553119

CDK2
Cyclin-dependent kinase 2

1

1

High-throughput

0.479

High

553124

TKT
Transketolase

1

1

High-throughput

0.479

High

553128

CDC27
Cell division cycle protein 27 homolog

1

2

Small-scale

0.479

High

553130

AKT1
RAC-alpha serine/threonine-protein kinase

1

1

Small-scale

0.479

High

553132

MSX2
Homeobox protein MSX-2

1

1

High-throughput

0.479

High

553136

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

1

Small-scale

0.479

High

553140

MDHM
Malate dehydrogenase, mitochondrial

1

1

High-throughput

0.479

High

553146

YAP1
Transcriptional coactivator YAP1

1

2

High-throughput

0.479

High

553147

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.479

High

553148

RBP2
E3 SUMO-protein ligase RanBP2

1

1

High-throughput

0.479

High

553157

RND3
Rho-related GTP-binding protein RhoE

1

1

High-throughput

0.479

High

553161

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

553165

ACTC
Actin, alpha cardiac muscle 1

1

3

High-throughput

0.479

High

553172

KMT2A
Histone-lysine N-methyltransferase 2A

1

2

High-throughput

0.479

High

553182

NFX1
Transcriptional repressor NF-X1

1

1

High-throughput

0.479

High

553183

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

2

High-throughput

0.479

High

553186

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

553187

SQSTM
Sequestosome-1

1

2

High-throughput

0.479

High

553201

DDR2
Discoidin domain-containing receptor 2

1

2

High-throughput

0.479

High

553206

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.479

High

553210

RHG17
Rho GTPase-activating protein 17

1

2

High-throughput

0.479

High

553214

RHGBA
Rho GTPase-activating protein 11A

1

4

High-throughput

0.479

High

553220

CNTRL
Centriolin

1

3

High-throughput

0.479

High

553228

SMC5
Structural maintenance of chromosomes protein 5

1

2

High-throughput

0.479

High

553232

CNTRB
Centrobin

1

3

High-throughput

0.479

High

553238

UBP38
Ubiquitin carboxyl-terminal hydrolase 38

1

1

Small-scale

0.479

High

553241

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

553246

RIN3
Ras and Rab interactor 3

1

1

High-throughput

0.479

High

553254

AKAP1
A-kinase anchor protein 1, mitochondrial

1

2

High-throughput

0.479

High

553262

BICD1
Protein bicaudal D homolog 1

1

2

High-throughput

0.479

High

553266

DCBD2
Discoidin, CUB and LCCL domain-containing protein 2

1

2

High-throughput

0.479

High

553267

NECD
Necdin

1

1

High-throughput

0.479

High

553269

BAG1
BAG family molecular chaperone regulator 1

1

1

High-throughput

0.479

High

553276

RHG39
Rho GTPase-activating protein 39

1

2

High-throughput

0.479

High

553280

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

553283

CPAP
Centrosomal P4.1-associated protein

1

3

High-throughput

0.479

High

553290

HDAC6
Protein deacetylase HDAC6

1

2

High-throughput

0.479

High

553291

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

553293

ANC2
Anaphase-promoting complex subunit 2

1

3

High-throughput

0.479

High

553294

FZR1
Fizzy-related protein homolog

1

3

High-throughput

0.479

High

553296

HDAC5
Histone deacetylase 5

1

2

High-throughput

0.479

High

553297

FND3A
Fibronectin type-III domain-containing protein 3A

1

1

High-throughput

0.479

High

553300

MTCH2
Mitochondrial carrier homolog 2

1

3

High-throughput

0.479

High

553292

S12A6
Solute carrier family 12 member 6

1

0

Small-scale

0.473

High

124216

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.458

High

125191

LEG9
Galectin-9

1

0

High-throughput

0.458

High

129974

PGRC1
Membrane-associated progesterone receptor component 1

1

0

Small-scale

0.458

High

369606

A2MG
Alpha-2-macroglobulin

1

0

High-throughput

0.458

High

400208

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

442985

PTMA
Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]

1

0

High-throughput

0.458

High

459424

PROF1
Profilin-1

1

0

High-throughput

0.458

High

553109

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

553114

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

1

0

High-throughput

0.458

High

553120

PSA3
Proteasome subunit alpha type-3

1

0

Small-scale

0.458

High

553122

CALR
Calreticulin

1

0

High-throughput

0.458

High

553123

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.458

High

553126

PDIA3
Protein disulfide-isomerase A3

1

0

High-throughput

0.458

High

553142

PERI
Peripherin

1

0

High-throughput

0.458

High

553149

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.458

High

553150

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

553151

ATX3
Ataxin-3

1

0

High-throughput

0.458

High

553153

TPIS
Triosephosphate isomerase

1

0

High-throughput

0.458

High

553155

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

553156

RS3A
Small ribosomal subunit protein eS1

1

0

High-throughput

0.458

High

553158

CH10
10 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.458

High

553159

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.458

High

553163

RHOB
Rho-related GTP-binding protein RhoB

1

0

High-throughput

0.458

High

553164

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

High-throughput

0.458

High

553166

CXAR
Coxsackievirus and adenovirus receptor

1

0

High-throughput

0.458

High

553167

BASP1
Brain acid soluble protein 1

1

0

High-throughput

0.458

High

553168

RL19
Large ribosomal subunit protein eL19

1

0

High-throughput

0.458

High

553169

VIGLN
Vigilin

1

0

High-throughput

0.458

High

553171

CAP1
Adenylyl cyclase-associated protein 1

1

0

High-throughput

0.458

High

553174

K1C17
Keratin, type I cytoskeletal 17

1

0

High-throughput

0.458

High

553181

TFCP2
Alpha-globin transcription factor CP2

1

0

High-throughput

0.458

High

553184

TADBP
TAR DNA-binding protein 43

1

0

Small-scale

0.458

High

553188

DCTN2
Dynactin subunit 2

1

0

High-throughput

0.458

High

553193

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

553195

CUL7
Cullin-7

1

0

High-throughput

0.458

High

553204

LARP7
La-related protein 7

1

0

High-throughput

0.458

High

553205

MIDN
Midnolin

1

0

High-throughput

0.458

High

553211

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.458

High

553221

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

0

High-throughput

0.458

High

553222

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

553225

ARMC8
Armadillo repeat-containing protein 8

1

0

High-throughput

0.458

High

553231

SPICE
Spindle and centriole-associated protein 1

1

0

High-throughput

0.458

High

553243

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

553253

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

553270

B9D2
B9 domain-containing protein 2

1

0

High-throughput

0.458

High

553273

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

553275

SPEF2
Sperm flagellar protein 2

1

0

High-throughput

0.458

High

553277

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

553285

NGB
Neuroglobin

1

0

High-throughput

0.458

High

553298

SBDS
Ribosome maturation protein SBDS

1

0

High-throughput

0.458

High

184566

MK13
Mitogen-activated protein kinase 13

1

1

Small-scale

0.445

High

327767

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

2

High-throughput

0.445

High

429212

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

553154

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

2

High-throughput

0.445

High

553175

TLE1
Transducin-like enhancer protein 1

1

1

High-throughput

0.445

High

553212

PKHA7
Pleckstrin homology domain-containing family A member 7

1

3

High-throughput

0.445

High

553215

OLFM4
Olfactomedin-4

1

3

High-throughput

0.445

High

553279

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

2

High-throughput

0.445

High

553257

TRI63
E3 ubiquitin-protein ligase TRIM63

1

5

High-throughput

0.439

High

553287

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

72913

FHAD1
Forkhead-associated domain-containing protein 1

1

2

High-throughput

0.437

High

105219

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

553121

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

553131

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

553134

FUS
RNA-binding protein FUS

1

1

High-throughput

0.437

High

553192

RBM39
RNA-binding protein 39

1

1

High-throughput

0.437

High

553197

NONO
Non-POU domain-containing octamer-binding protein

1

2

High-throughput

0.437

High

553200

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.437

High

553207

RC3H1
Roquin-1

1

3

Small-scale

0.437

High

553216

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

553218

KCTD9
BTB/POZ domain-containing protein KCTD9

1

2

High-throughput

0.437

High

553223

ZCH18
Zinc finger CCCH domain-containing protein 18

1

1

High-throughput

0.437

High

553224

GOLI
E3 ubiquitin-protein ligase RNF130

1

1

High-throughput

0.437

High

553229

S15A3
Solute carrier family 15 member 3

1

1

High-throughput

0.437

High

553230

SLX4
Structure-specific endonuclease subunit SLX4

1

4

High-throughput

0.437

High

553235

LZTR1
Leucine-zipper-like transcriptional regulator 1

1

1

Small-scale

0.437

High

553237

CE120
Centrosomal protein of 120 kDa

1

1

High-throughput

0.437

High

553240

RN149
E3 ubiquitin-protein ligase RNF149

1

1

High-throughput

0.437

High

553252

KAT6B
Histone acetyltransferase KAT6B

1

1

High-throughput

0.437

High

553274

TRI55
Tripartite motif-containing protein 55

1

5

High-throughput

0.437

High

553281

WDR76
WD repeat-containing protein 76

1

2

High-throughput

0.437

High

553282

RC3H2
Roquin-2

1

5

Small-scale

0.437

High

553295

PRP19
Pre-mRNA-processing factor 19

1

1

Small-scale

0.437

High

261069

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.426

High

553180

LG3BP
Galectin-3-binding protein

1

0

High-throughput

0.426

High

553194

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

0

High-throughput

0.426

High

553227

S41A1
Solute carrier family 41 member 1

1

0

High-throughput

0.426

High

553244

MFSD8
Major facilitator superfamily domain-containing protein 8

1

0

High-throughput

0.426

High

553249

G6PT3
Glucose-6-phosphate exchanger SLC37A2

1

0

High-throughput

0.426

High

553256

RBPMS
RNA-binding protein with multiple splicing

1

0

High-throughput

0.426

High

553261

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

104096

F5H1C8
Solute carrier family 15 member 3

1

1

High-throughput

0.407

High

330028

VENTX
Homeobox protein VENTX

1

1

High-throughput

0.407

High

553162

ERR3
Estrogen-related receptor gamma

1

3

High-throughput

0.407

High

553152

TERF1
Telomeric repeat-binding factor 1

1

0

High-throughput

0.288

High

553259

ACD
Adrenocortical dysplasia protein homolog

1

0

High-throughput

0.288

High

553271

TINF2
TERF1-interacting nuclear factor 2

1

0

High-throughput

0.288

High

553288

POTE1
Protection of telomeres protein 1

1

0

High-throughput

0.288

High

553236

SERP2
Stress-associated endoplasmic reticulum protein 2

1

0

High-throughput

0.282

High

553133

SOAT1
Sterol O-acyltransferase 1

1

0

High-throughput

0.279

Low

553143

RAD52
DNA repair protein RAD52 homolog

1

0

Small-scale

0.279

Low

553248

MIPT3
TRAF3-interacting protein 1

1

0

Small-scale

0.279

Low

553258

NCLN
BOS complex subunit NCLN

1

0

High-throughput

0.279

Low

553278

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.279

Low

553111

ITF2
Transcription factor 4

1

0

High-throughput

0.261

Low

553177

PAX8
Paired box protein Pax-8

1

0

High-throughput

0.261

Low

553272

KLF16
Krueppel-like factor 16

1

0

High-throughput

0.261

Low

324475

HEXI1
Protein HEXIM1

1

0

High-throughput

0.249

Low

553209

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low

553213

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

High-throughput

0.249

Low

553217

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.249

Low

553239

POC1A
POC1 centriolar protein homolog A

1

0

High-throughput

0.249

Low

553250

DUS19
Dual specificity protein phosphatase 19

1

0

High-throughput

0.249

Low

553263

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

553284

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

0

High-throughput

0.249

Low

553286

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

0

High-throughput

0.249

Low

553289

HSFX1
Heat shock transcription factor, X-linked

1

0

High-throughput

0.249

Low

553173

P
P protein

1

0

High-throughput

0.232

Low

553198

SF01
Splicing factor 1

1

0

High-throughput

0.232

Low

553226

LACC1
Purine nucleoside phosphorylase LACC1

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025