HitPredict

Interactor 1: GATA2 (P23769)
Endothelial transcription factor GATA-2 (GATA-binding protein 2)
Gene: GATA2

Interactor 2: TLE4 (Q04727)
Transducin-like enhancer protein 4 (Grg-4) (Groucho-related protein 4)
Gene: TLE4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005667 - transcription regulator complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 480 Hs			1 773
+	Hs
		620329 GATA2_HUMAN (1-480): 0: 529: 100.00		TLE1_HUMAN (8-773): 0: 580: 86.27
+	Hs
		620330 GATA2_HUMAN (1-480): 0: 529: 100.00		TLE3_HUMAN (8-773): 0: 539: 80.90
+	Hs
		620481 GATA3_HUMAN (1-480): 3.1e-135: 399: 61.24		TLE1_HUMAN (8-773): 0: 580: 86.27
+	Hs
		620482 GATA3_HUMAN (1-480): 3.1e-135: 399: 61.24		TLE3_HUMAN (8-773): 0: 539: 80.90
+	Hs
		620335 GATA2_HUMAN (1-480): 0: 529: 100.00		TLE5_HUMAN (8-205): 3.48e-94: 293: 67.68
+	Hs
		554431 GATA1_HUMAN (186-480): 8.32e-69: 227: 43.35		TLE1_HUMAN (8-773): 0: 580: 86.27
+	Hs
		554432 GATA1_HUMAN (186-480): 8.32e-69: 227: 43.35		TLE3_HUMAN (8-773): 0: 539: 80.90
+	Hs
		980900 TRPS1_HUMAN (153-447): 1.96e-56: 204: 23.76		TLE3_HUMAN (8-773): 0: 539: 80.90
+	Hs
		245560 GATA2_HUMAN (1-480): 0: 529: 100.00		TBL1X_HUMAN (572-772): 8.38e-46: 174: 15.60
+	Hs
		620487 GATA3_HUMAN (1-480): 3.1e-135: 399: 61.24		TLE5_HUMAN (8-205): 3.48e-94: 293: 67.68
+	Hs
		620419 GATA2_HUMAN (1-480): 0: 529: 100.00		TBL1R_HUMAN (651-770): 4.06e-20: 96.4: 13.24
+	Hs
		245561 GATA3_HUMAN (1-480): 3.1e-135: 399: 61.24		TBL1X_HUMAN (572-772): 8.38e-46: 174: 15.60
+	Hs
		554438 GATA1_HUMAN (186-480): 8.32e-69: 227: 43.35		TLE5_HUMAN (8-205): 3.48e-94: 293: 67.68
+	Hs
		620569 GATA3_HUMAN (1-480): 3.1e-135: 399: 61.24		TBL1R_HUMAN (651-770): 4.06e-20: 96.4: 13.24
+	Hs
		245558 GATA1_HUMAN (186-480): 8.32e-69: 227: 43.35		TBL1X_HUMAN (572-772): 8.38e-46: 174: 15.60
+	Hs
		799000 GATA4_HUMAN (107-479): 1.15e-69: 230: 32.41		TBL1R_HUMAN (651-770): 4.06e-20: 96.4: 13.24
+	Hs
		798837 GATA4_HUMAN (107-479): 1.15e-69: 230: 32.41		GBB2_HUMAN (689-772): 2.72e-14: 76.8: 16.47
+	Hs
		798841 GATA4_HUMAN (107-479): 1.15e-69: 230: 32.41		RACK1_HUMAN (473-675): 5.84e-12: 69.3: 25.37
+	Rn
		803059 GATA4_RAT (107-479): 3.62e-66: 221: 32.41		GBB2_RAT (689-772): 2.72e-14: 76.8: 16.47
+	Ce
		567433 ELT2_CAEEL (146-416): 3.71e-64: 215: 26.03		GBB1_CAEEL (658-772): 2.73e-14: 76.7: 17.50