HitPredict

Interactor 1: RPB3 (P19387)
DNA-directed RNA polymerase II subunit RPB3 (RNA polymerase II subunit 3) (RNA polymerase II subunit B3) (DNA-directed RNA polymerase II 33 kDa polypeptide) (RPB33) (DNA-directed RNA polymerase II subunit C) (RPB31)
Gene: POLR2C

Interactor 2: RPB11 (P52435)
DNA-directed RNA polymerase II subunit RPB11-a (RNA polymerase II subunit B11-a) (RPB11a) (DNA-directed RNA polymerase II subunit J-1) (RNA polymerase II 13.3 kDa subunit)
Gene: POLR2J

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.92 1.00 0.964

The method score is based on:

Property Details
Experiments 9201987, 33961781, 35271311, 24981860, 12207009, 18562274, unassigned3799
Identification Methods pull down, affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains RNA_pol_L~RNA_pol_L_2
Common GO terms GO:0003677 - DNA binding
GO:0003899 - DNA-directed RNA polymerase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005665 - RNA polymerase II, core complex
and 2 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 275
Hs

1 117
+ Mm
+ Hs
+ Dm
+ Hs
+ Hs
+ Hs
+ Sc
+ Hs
+ At
+ At
+ Sc
+ Sp
+ Sp
+ Dm
+ Sc
+ Ss
+ Mj

Service provided by Combinatics, Japan

Last updated: 11Aug2025