Protein: RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2 (RNA polymerases I and III subunit AC2) (AC19) (DNA-directed RNA polymerases I and III 16 kDa polypeptide) (RPA19)

Gene: RPAC2, RPC19
Organism: Saccharomyces cerevisiae S288C
Interactions: 129
UniProt ID: P28000

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0003899 - DNA-directed RNA polymerase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005666 - RNA polymerase III complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

459041

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

11

17

Small-scale

0.980

High

647028

RPC2
DNA-directed RNA polymerase III subunit RPC2

8

9

Small-scale

0.966

High

644880

RPA2
DNA-directed RNA polymerase I subunit RPA135

6

9

Small-scale

0.949

High

402198

RPC1
DNA-directed RNA polymerase III subunit RPC1

5

11

Small-scale

0.922

High

534225

RPA1
DNA-directed RNA polymerase I subunit RPA190

5

11

Small-scale

0.919

High

594235

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

17

Small-scale

0.775

High

632136

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

4

3

Small-scale

0.684

High

699987

RPA12
DNA-directed RNA polymerase I subunit RPA12

3

9

High-throughput

0.662

High

699993

RPC8
DNA-directed RNA polymerase III subunit RPC8

3

5

High-throughput

0.657

High

699983

RPC3
DNA-directed RNA polymerase III subunit RPC3

3

1

High-throughput

0.650

High

700015

RPA43
DNA-directed RNA polymerase I subunit RPA43

3

1

Small-scale

0.650

High

674390

RPC4
DNA-directed RNA polymerase III subunit RPC4

3

0

High-throughput

0.634

High

700017

RPA34
DNA-directed RNA polymerase I subunit RPA34

3

0

High-throughput

0.622

High

632315

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

3

High-throughput

0.618

High

700035

RAGAB
GTP-binding protein GTR1

2

0

Small-scale

0.613

High

632236

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

2

4

High-throughput

0.601

High

645030

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

2

4

High-throughput

0.601

High

699990

RPC6
DNA-directed RNA polymerase III subunit RPC6

2

1

High-throughput

0.601

High

700037

RPA49
DNA-directed RNA polymerase I subunit RPA49

2

2

High-throughput

0.601

High

699980

TF3B
Transcription factor IIIB 70 kDa subunit

2

5

High-throughput

0.584

High

700010

DSN1
Kinetochore-associated protein DSN1

2

1

High-throughput

0.584

High

609179

RPC7
DNA-directed RNA polymerase III subunit RPC7

2

0

High-throughput

0.576

High

700022

RPC9
DNA-directed RNA polymerase III subunit RPC9

2

0

High-throughput

0.576

High

440907

CDC7
Cell division control protein 7

1

2

High-throughput

0.536

High

444745

SIR2
NAD-dependent histone deacetylase SIR2

1

1

High-throughput

0.515

High

656940

BUR1
Serine/threonine-protein kinase BUR1

1

1

High-throughput

0.515

High

381918

H4
Histone H4

1

0

High-throughput

0.513

High

699981

HRR25
Casein kinase I homolog HRR25

1

0

High-throughput

0.513

High

700004

RIX1
Pre-rRNA-processing protein RIX1

1

0

High-throughput

0.513

High

700038

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

0

High-throughput

0.513

High

700047

PDR8
Transcription factor PDR8

1

1

High-throughput

0.508

High

699986

ASF1
Histone chaperone ASF1

1

0

High-throughput

0.493

High

700054

NSI1
RNA polymerase I termination factor

1

0

High-throughput

0.493

High

700026

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

1

High-throughput

0.489

High

700027

XRCC4
Non-homologous end-joining factor LIF1

1

0

High-throughput

0.486

High

555234

RAD50
DNA repair protein RAD50

1

1

High-throughput

0.481

High

700018

YJ41B
Transposon Ty4-J Gag-Pol polyprotein

1

1

High-throughput

0.481

High

700041

ULP1
Ubiquitin-like-specific protease 1

1

1

High-throughput

0.481

High

440825

KIN28
Serine/threonine-protein kinase KIN28

1

0

High-throughput

0.480

High

673682

KCC4
Probable serine/threonine-protein kinase KCC4

1

0

High-throughput

0.480

High

700020

IKS1
Probable serine/threonine-protein kinase IKS1

1

0

High-throughput

0.480

High

486065

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.479

High

434886

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

699979

TF2B
Transcription initiation factor IIB

1

5

High-throughput

0.479

High

699988

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

2

High-throughput

0.479

High

699997

RPC5
DNA-directed RNA polymerase III subunit RPC5

1

2

High-throughput

0.479

High

700009

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

3

High-throughput

0.479

High

700012

UTP10
U3 small nucleolar RNA-associated protein 10

1

1

High-throughput

0.479

High

700016

TFC5
Transcription factor TFIIIB component B''

1

1

High-throughput

0.479

High

700034

SEN1
Helicase SEN1

1

2

High-throughput

0.479

High

700036

CDC14
Tyrosine-protein phosphatase CDC14

1

1

High-throughput

0.479

High

700042

TOM1
E3 ubiquitin-protein ligase TOM1

1

4

High-throughput

0.479

High

700043

RPC10
DNA-directed RNA polymerase III subunit RPC10

1

9

High-throughput

0.479

High

700048

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.479

High

700050

IWR1
RNA polymerase II nuclear localization protein IWR1

1

1

High-throughput

0.479

High

700053

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

1

High-throughput

0.479

High

699982

XPO1
Exportin-1

1

0

High-throughput

0.460

High

149629

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.458

High

364379

CDK1
Cyclin-dependent kinase 1

1

0

High-throughput

0.458

High

441750

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

448289

PDE2
3',5'-cyclic-nucleotide phosphodiesterase 2

1

0

High-throughput

0.458

High

512302

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.458

High

561427

TBP
TATA-box-binding protein

1

0

High-throughput

0.458

High

672858

RRP43
Exosome complex component RRP43

1

0

High-throughput

0.458

High

674460

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

677309

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.458

High

682183

SPB4
ATP-dependent rRNA helicase SPB4

1

0

High-throughput

0.458

High

689307

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

699994

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.458

High

699999

RRN10
RNA polymerase I-specific transcription initiation factor RRN10

1

0

High-throughput

0.458

High

700013

BUD27
Bud site selection protein 27

1

0

High-throughput

0.458

High

700023

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

700025

RPA14
DNA-directed RNA polymerase I subunit RPA14

1

0

High-throughput

0.458

High

700030

RRN9
RNA polymerase I-specific transcription initiation factor RRN9

1

0

High-throughput

0.458

High

700033

ORC1
Origin recognition complex subunit 1

1

0

High-throughput

0.458

High

700045

RBS1
RNA-binding suppressor of PAS kinase protein 1

1

0

Small-scale

0.458

High

700051

SGO1
Shugoshin

1

0

High-throughput

0.458

High

660310

STE11
Serine/threonine-protein kinase STE11

1

1

High-throughput

0.457

High

366959

ATPB
ATP synthase subunit beta, mitochondrial

1

3

High-throughput

0.457

High

452841

ATPA
ATP synthase subunit alpha, mitochondrial

1

3

High-throughput

0.457

High

592061

VATB
V-type proton ATPase subunit B

1

3

High-throughput

0.457

High

523246

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.445

High

526085

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

700007

PFD2
Prefoldin subunit 2

1

1

High-throughput

0.439

High

699992

RS3A1
Small ribosomal subunit protein eS1A

1

3

High-throughput

0.437

High

700000

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.437

High

700019

NET1
Nucleolar protein NET1

1

1

High-throughput

0.437

High

700031

GIS2
Zinc finger protein GIS2

1

2

High-throughput

0.437

High

700040

TOF2
Topoisomerase 1-associated factor 2

1

1

High-throughput

0.437

High

700049

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.437

High

544041

SSB1
Ribosome-associated molecular chaperone SSB1

1

0

High-throughput

0.426

High

699996

RRN3
RNA polymerase I-specific transcription initiation factor RRN3

1

0

Small-scale

0.426

High

700002

SSZ1
Ribosome-associated complex subunit SSZ1

1

0

High-throughput

0.426

High

510261

HSP77
Import motor subunit, mitochondrial

1

3

High-throughput

0.407

High

700006

HSP7E
Heat shock protein SSC3, mitochondrial

1

3

High-throughput

0.407

High

700046

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

5

High-throughput

0.407

High

700014

MIC19
MICOS complex subunit MIC19

2

0

High-throughput

0.326

High

700001

PHS
Putative pterin-4-alpha-carbinolamine dehydratase

2

0

High-throughput

0.314

High

699985

MDHP
Malate dehydrogenase, peroxisomal

1

0

High-throughput

0.269

Low

699991

BUD2
Inhibitory regulator protein BUD2/CLA2

1

0

High-throughput

0.269

Low

700055

ATG11
Autophagy-related protein 11

1

0

High-throughput

0.269

Low

386602

TBB
Tubulin beta chain

1

0

High-throughput

0.261

Low

394305

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.261

Low

416390

HXKA
Hexokinase-1

1

0

High-throughput

0.261

Low

484733

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.261

Low

554886

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.261

Low

700011

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.261

Low

699984

SMY1
Kinesin-related protein SMY1

1

0

High-throughput

0.251

Low

700008

TSC11
Target of rapamycin complex 2 subunit TSC11

1

0

High-throughput

0.251

Low

700021

YJE9
Uncharacterized protein YJL049W

1

0

High-throughput

0.251

Low

700028

KXD1
Biogenesis of lysosome-related organelles complex 1 subunit KXD1

1

0

High-throughput

0.251

Low

700029

NNF2
Protein NNF2

1

0

High-throughput

0.251

Low

383563

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

433495

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

435821

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.249

Low

454922

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

502893

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

512865

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

514499

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.249

Low

699989

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.249

Low

699995

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

699998

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

700003

NMD2
Nonsense-mediated mRNA decay protein 2

1

0

Small-scale

0.249

Low

700005

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

700024

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

700039

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

700044

VMS1
tRNA endonuclease VMS1

1

0

High-throughput

0.249

Low

700052

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low

700032

JJJ1
J protein JJJ1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025