Protein: RPB11
DNA-directed RNA polymerase II subunit RPB11-a (RNA polymerase II subunit B11-a) (RPB11a) (DNA-directed RNA polymerase II subunit J-1) (RNA polymerase II 13.3 kDa subunit)

Gene: RPB11, POLR2J
Organism: Homo sapiens
Interactions: 151
UniProt ID: P52435

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0003899 - DNA-directed RNA polymerase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005665 - RNA polymerase II, core complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

180258

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

7

17

High-throughput

0.969

High

621602

RPB3
DNA-directed RNA polymerase II subunit RPB3

7

17

Small-scale

0.964

High

667227

RPB1
DNA-directed RNA polymerase II subunit RPB1

7

11

Small-scale

0.960

High

722918

RPB2
DNA-directed RNA polymerase II subunit RPB2

6

9

Small-scale

0.940

High

912036

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

4

3

High-throughput

0.895

High

912169

RPB7
DNA-directed RNA polymerase II subunit RPB7

9

5

Small-scale

0.752

High

912249

PIHD1
PIH1 domain-containing protein 1

7

1

High-throughput

0.745

High

912164

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

2

3

High-throughput

0.737

High

192798

RPB4
DNA-directed RNA polymerase II subunit RPB4

6

2

Small-scale

0.736

High

621841

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

6

3

Small-scale

0.732

High

912200

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

5

2

High-throughput

0.716

High

912242

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

5

3

High-throughput

0.716

High

912224

RPAP1
RNA polymerase II-associated protein 1

5

3

Small-scale

0.712

High

912239

GPN1
GPN-loop GTPase 1

5

7

High-throughput

0.712

High

912167

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

4

4

High-throughput

0.699

High

912165

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

4

3

Small-scale

0.696

High

912226

RPB1B
DNA-directed RNA polymerase II subunit RPB11-b1

1

3

High-throughput

0.691

High

316369

RMP
Unconventional prefoldin RPB5 interactor 1

4

1

High-throughput

0.691

High

912170

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

4

4

High-throughput

0.691

High

335973

MED26
Mediator of RNA polymerase II transcription subunit 26

5

0

High-throughput

0.686

High

912264

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

4

1

Small-scale

0.683

High

787734

RPB9
DNA-directed RNA polymerase II subunit RPB9

3

8

High-throughput

0.667

High

912219

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

3

3

High-throughput

0.662

High

912251

MED29
Mediator of RNA polymerase II transcription subunit 29

4

0

High-throughput

0.661

High

912171

TF2B
Transcription initiation factor IIB

3

5

Small-scale

0.656

High

912236

GPN2
GPN-loop GTPase 2

5

7

High-throughput

0.654

High

239554

MED14
Mediator of RNA polymerase II transcription subunit 14

3

3

High-throughput

0.650

High

912188

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

3

2

High-throughput

0.650

High

912199

SPT6H
Transcription elongation factor SPT6

3

1

High-throughput

0.650

High

912255

UXT
Protein UXT

3

1

High-throughput

0.650

High

912233

RPAP3
RNA polymerase II-associated protein 3

5

2

High-throughput

0.650

High

48930

MED19
Mediator of RNA polymerase II transcription subunit 19

3

0

High-throughput

0.638

High

912177

MED21
Mediator of RNA polymerase II transcription subunit 21

3

0

High-throughput

0.638

High

912258

GPN3
GPN-loop GTPase 3

4

7

High-throughput

0.630

High

130410

SPT5H
Transcription elongation factor SPT5

2

1

High-throughput

0.628

High

681771

RBTN2
Rhombotin-2

2

1

High-throughput

0.628

High

912190

INT3
Integrator complex subunit 3

3

0

High-throughput

0.628

High

912229

MED28
Mediator of RNA polymerase II transcription subunit 28

3

0

High-throughput

0.628

High

316270

RECQ5
ATP-dependent DNA helicase Q5

3

0

High-throughput

0.622

High

912181

MED1
Mediator of RNA polymerase II transcription subunit 1

3

0

High-throughput

0.622

High

912241

MED4
Mediator of RNA polymerase II transcription subunit 4

3

0

High-throughput

0.622

High

912245

MED17
Mediator of RNA polymerase II transcription subunit 17

3

0

High-throughput

0.622

High

165025

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

11

High-throughput

0.618

High

339961

RPA1
DNA-directed RNA polymerase I subunit RPA1

1

11

High-throughput

0.618

High

912237

RPA2
DNA-directed RNA polymerase I subunit RPA2

1

9

High-throughput

0.618

High

912247

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

9

High-throughput

0.618

High

912191

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

4

1

High-throughput

0.617

High

131847

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

2

2

High-throughput

0.611

High

912234

SFR19
Splicing factor, arginine/serine-rich 19

2

3

High-throughput

0.611

High

63176

VP37C
Vacuolar protein sorting-associated protein 37C

2

2

High-throughput

0.606

High

140192

SDCB1
Syntenin-1

2

1

High-throughput

0.606

High

912223

TRAF4
TNF receptor-associated factor 4

2

2

High-throughput

0.606

High

912212

CPNE2
Copine-2

2

0

High-throughput

0.602

High

505946

MYZAP
Myocardial zonula adherens protein

2

2

High-throughput

0.601

High

912218

DAA10
Dynein axonemal assembly factor 10

3

1

High-throughput

0.593

High

506001

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

3

0

High-throughput

0.585

High

326313

SCAF4
SR-related and CTD-associated factor 4

2

0

High-throughput

0.585

High

912179

MED22
Mediator of RNA polymerase II transcription subunit 22

2

0

High-throughput

0.585

High

912215

MED30
Mediator of RNA polymerase II transcription subunit 30

2

0

High-throughput

0.585

High

912221

MED10
Mediator of RNA polymerase II transcription subunit 10

2

0

High-throughput

0.585

High

912248

MED9
Mediator of RNA polymerase II transcription subunit 9

2

0

High-throughput

0.585

High

569078

T2FB
General transcription factor IIF subunit 2

2

1

Small-scale

0.584

High

770358

T2FA
General transcription factor IIF subunit 1

2

1

Small-scale

0.584

High

217071

MS18B
Protein Mis18-beta

2

0

High-throughput

0.580

High

299820

SNPC5
snRNA-activating protein complex subunit 5

2

0

High-throughput

0.580

High

581761

MYOG
Myogenin

2

0

High-throughput

0.580

High

912214

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.580

High

912202

KIF2B
Kinesin-like protein KIF2B

2

1

High-throughput

0.574

High

287775

MED6
Mediator of RNA polymerase II transcription subunit 6

2

1

High-throughput

0.571

High

912254

PHRF1
PHD and RING finger domain-containing protein 1

2

4

High-throughput

0.558

High

912193

MED27
Mediator of RNA polymerase II transcription subunit 27

2

0

High-throughput

0.547

High

856599

BAG6
Large proline-rich protein BAG6

1

1

High-throughput

0.541

High

774940

FUS
RNA-binding protein FUS

1

1

High-throughput

0.536

High

912175

SSRP1
FACT complex subunit SSRP1

1

1

High-throughput

0.536

High

912206

STYX
Serine/threonine/tyrosine-interacting protein

1

1

High-throughput

0.536

High

912220

SCAFB
Protein SCAF11

1

2

High-throughput

0.536

High

912228

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

4

High-throughput

0.536

High

912230

NELFA
Negative elongation factor A

1

1

High-throughput

0.536

High

912252

AATF
Protein AATF

1

0

Small-scale

0.529

High

912173

SATB1
DNA-binding protein SATB1

1

2

Small-scale

0.527

High

912243

PDRG1
p53 and DNA damage-regulated protein 1

2

1

High-throughput

0.521

High

477959

SNRPA
U1 small nuclear ribonucleoprotein A

1

0

High-throughput

0.513

High

480063

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.513

High

541905

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.513

High

574182

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

0

High-throughput

0.513

High

912168

RUXF
Small nuclear ribonucleoprotein F

1

0

High-throughput

0.513

High

912185

GRDN
Girdin

1

0

High-throughput

0.513

High

912192

GTD2B
General transcription factor II-I repeat domain-containing protein 2B

1

0

High-throughput

0.513

High

912198

INT8
Integrator complex subunit 8

1

0

High-throughput

0.513

High

912207

NELFB
Negative elongation factor B

1

0

High-throughput

0.513

High

912209

TRI52
E3 ubiquitin-protein ligase TRIM52

1

0

High-throughput

0.513

High

912211

INT12
Integrator complex subunit 12

1

0

High-throughput

0.513

High

912222

MED18
Mediator of RNA polymerase II transcription subunit 18

1

0

High-throughput

0.513

High

912244

INT9
Integrator complex subunit 9

1

0

High-throughput

0.513

High

912266

MOFA1
MORF4 family-associated protein 1

1

0

High-throughput

0.513

High

190859

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

1

High-throughput

0.479

High

262500

MCE1
mRNA-capping enzyme

1

2

High-throughput

0.479

High

287445

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

2

High-throughput

0.479

High

371528

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

405929

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

430617

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

2

High-throughput

0.479

High

683413

IKBA
NF-kappa-B inhibitor alpha

1

1

High-throughput

0.479

High

912166

ELOF1
Transcription elongation factor 1 homolog

1

1

Small-scale

0.479

High

912180

TCEA2
Transcription elongation factor A protein 2

1

6

High-throughput

0.479

High

912204

SIR6
NAD-dependent protein deacylase sirtuin-6

1

1

High-throughput

0.479

High

912227

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

2

High-throughput

0.479

High

912246

RPC5
DNA-directed RNA polymerase III subunit RPC5

1

2

High-throughput

0.479

High

912253

RPA12
DNA-directed RNA polymerase I subunit RPA12

1

9

High-throughput

0.479

High

912256

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

912257

PFD2
Prefoldin subunit 2

1

1

High-throughput

0.479

High

912262

RPC10
DNA-directed RNA polymerase III subunit RPC10

1

8

High-throughput

0.479

High

912263

RPC8
DNA-directed RNA polymerase III subunit RPC8

1

5

High-throughput

0.479

High

912189

LAR1B
La-related protein 1B

1

0

High-throughput

0.460

High

912259

TEN1
Teneurin-1

1

0

Small-scale

0.460

High

798879

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

905361

HCFC1
Host cell factor 1

1

0

High-throughput

0.458

High

912172

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

0

High-throughput

0.458

High

912178

CUL3
Cullin-3

1

0

High-throughput

0.458

High

912182

ELAV1
ELAV-like protein 1

1

0

High-throughput

0.458

High

912183

DDB1
DNA damage-binding protein 1

1

0

High-throughput

0.458

High

912187

MEIG1
Meiosis expressed gene 1 protein homolog

1

0

High-throughput

0.458

High

912194

INT5
Integrator complex subunit 5

1

0

High-throughput

0.458

High

912213

MED8
Mediator of RNA polymerase II transcription subunit 8

1

0

High-throughput

0.458

High

912235

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.458

High

912260

INT6
Integrator complex subunit 6

1

0

High-throughput

0.458

High

912265

RBM8A
RNA-binding protein 8A

1

0

High-throughput

0.458

High

912210

ARMC5
Armadillo repeat-containing protein 5

1

1

High-throughput

0.445

High

912238

LN28A
Protein lin-28 homolog A

1

2

High-throughput

0.445

High

912240

TUFT1
Tuftelin

1

2

High-throughput

0.445

High

912196

SYDE1
Rho GTPase-activating protein SYDE1

2

0

High-throughput

0.328

High

912250

ASB6
Ankyrin repeat and SOCS box protein 6

2

0

High-throughput

0.328

High

912186

DRC12
Dynein regulatory complex protein 12

2

0

High-throughput

0.316

High

471540

CD14
Monocyte differentiation antigen CD14

1

0

High-throughput

0.282

High

485931

GIP
Gastric inhibitory polypeptide

1

0

High-throughput

0.279

Low

912174

ATP7A
Copper-transporting ATPase 1

1

0

High-throughput

0.279

Low

912176

SBP1
Methanethiol oxidase

1

0

High-throughput

0.279

Low

912184

KR197
Keratin-associated protein 19-7

1

0

High-throughput

0.279

Low

912203

KCD17
BTB/POZ domain-containing protein KCTD17

1

0

High-throughput

0.279

Low

912205

LRC15
Leucine-rich repeat-containing protein 15

1

0

High-throughput

0.279

Low

912208

F168A
Protein FAM168A

1

0

High-throughput

0.279

Low

912216

TET5A
Terminal nucleotidyltransferase 5A

1

0

High-throughput

0.279

Low

912225

TNG6
Transport and Golgi organization protein 6 homolog

1

0

High-throughput

0.279

Low

912261

CLC11
C-type lectin domain family 11 member A

1

0

High-throughput

0.279

Low

912197

RFPLB
Ret finger protein-like 4B

1

0

High-throughput

0.249

Low

912232

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

388774

C1QC
Complement C1q subcomponent subunit C

1

0

High-throughput

0.232

Low

912195

CA122
Uncharacterized protein C1orf122

1

0

High-throughput

0.232

Low

912201

OFCC1
Orofacial cleft 1 candidate gene 1 protein

1

0

High-throughput

0.232

Low

912217

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.232

Low

912231

OSBL3
Oxysterol-binding protein-related protein 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025