HitPredict

Interactor 1: PRP22 (P24384)
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22 (EC 3.6.4.13)
Gene: PRP22

Interactor 2: CWC2 (Q12046)
Pre-mRNA-splicing factor CWC2 (Complexed with CEF1 protein 2) (PRP19-associated complex protein 40) (Synthetic lethal with CLF1 protein 3)
Gene: CWC2

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	19016306, 29146870, 20089683
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0071007 - U2-type catalytic step 2 spliceosome
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1145 Sc			1 339
+	Sc
		589464 PRP2_YEAST (252-1113): 0: 837: 34.18		CWC2_YEAST (1-339): 1.42e-172: 484: 100.00
+	Sc
		859454 PRP43_YEAST (416-1106): 0: 700: 45.80		CWC2_YEAST (1-339): 1.42e-172: 484: 100.00
+	Sp
		193839 PRP22_SCHPO (1-1138): 0: 918: 44.27		CWC2_SCHPO (7-302): 1.19e-76: 242: 35.64
+	Sc
		554253 PRP16_YEAST (217-1109): 0: 670: 35.31		CWC2_YEAST (1-339): 1.42e-172: 484: 100.00
+	Sp
		953371 PRP16_SCHPO (3-1145): 0: 819: 34.14		CWC2_SCHPO (7-302): 1.19e-76: 242: 35.64
+	Hs
		165476 DHX8_HUMAN (1-1137): 0: 949: 40.81		SR140_HUMAN (123-296): 1.8e-12: 70.3: 18.56
+	Sp
		953366 CDC28_SCHPO (4-1113): 0: 762: 32.50		CWC2_SCHPO (7-302): 1.19e-76: 242: 35.64
+	Sp
		194927 DHX15_SCHPO (410-1129): 0: 716: 44.82		CWC2_SCHPO (7-302): 1.19e-76: 242: 35.64
+	Hs
		165344 DHX15_HUMAN (471-1112): 0: 746: 47.10		SR140_HUMAN (123-296): 1.8e-12: 70.3: 18.56
+	Hs
		165454 DHX9_HUMAN (109-1144): 0: 683: 20.04		SR140_HUMAN (123-296): 1.8e-12: 70.3: 18.56