Protein: LYS4
Homoaconitase, mitochondrial (EC 4.2.1.36) (Homoaconitate hydratase)

Gene: LYS4
Organism: Saccharomyces cerevisiae S288C
Interactions: 47
UniProt ID: P49367

Gene Ontology (top 5):
GO:0004409 - homoaconitate hydratase activity
GO:0005739 - mitochondrion
GO:0019878 - lysine biosynthetic process via aminoadipic acid
GO:0046872 - metal ion binding
GO:0051539 - 4 iron, 4 sulfur cluster binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

739409

ZUO1
Zuotin

2

3

High-throughput

0.588

High

752486

HSP78
Heat shock protein 78, mitochondrial

2

4

High-throughput

0.571

High

727172

HS104
Heat shock protein 104

2

4

High-throughput

0.537

High

804293

SSZ1
Ribosome-associated complex subunit SSZ1

2

3

High-throughput

0.537

High

657109

IF5A1
Eukaryotic translation initiation factor 5A-1

1

1

High-throughput

0.515

High

790213

GLYC
Serine hydroxymethyltransferase, cytosolic

1

2

High-throughput

0.515

High

815501

RSP5
E3 ubiquitin-protein ligase RSP5

1

2

High-throughput

0.501

High

456431

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

2

High-throughput

0.479

High

510642

HSP77
Import motor subunit, mitochondrial

1

11

High-throughput

0.479

High

594975

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

1

5

High-throughput

0.479

High

604965

MDHM
Malate dehydrogenase, mitochondrial

1

4

High-throughput

0.479

High

746260

NFU1
NifU-like protein, mitochondrial

1

4

Small-scale

0.479

High

813881

BOL3
BolA-like protein 3

1

2

Small-scale

0.479

High

713627

EF1G1
Elongation factor 1-gamma 1

1

2

High-throughput

0.470

High

881819

ESP1
Separin

1

0

High-throughput

0.458

High

881822

ETFD
Probable electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial

1

0

High-throughput

0.458

High

527129

HSP72
Heat shock protein SSA2

1

10

High-throughput

0.445

High

579717

HSC82
ATP-dependent molecular chaperone HSC82

1

5

High-throughput

0.445

High

881821

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

18

High-throughput

0.445

High

149856

RS9A
Small ribosomal subunit protein uS4A

1

1

High-throughput

0.437

High

410226

RL25
Large ribosomal subunit protein uL23

1

1

High-throughput

0.437

High

435221

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.437

High

442009

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.437

High

503137

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.437

High

504309

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

707599

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.437

High

802272

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.437

High

874416

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.437

High

881820

SCC2
Sister chromatid cohesion protein 2

1

2

High-throughput

0.437

High

881823

RRP6
Exosome complex exonuclease RRP6

1

1

High-throughput

0.437

High

524507

HSP71
Heat shock protein SSA1

1

10

High-throughput

0.407

High

545504

SSB1
Ribosome-associated molecular chaperone SSB1

1

11

High-throughput

0.407

High

597204

BIP
Endoplasmic reticulum chaperone BiP

1

4

High-throughput

0.407

High

741943

HSP7F
Heat shock protein homolog SSE1

1

15

High-throughput

0.407

High

810727

TCPB
T-complex protein 1 subunit beta

1

2

High-throughput

0.407

High

819219

SSB2
Ribosome-associated molecular chaperone SSB2

1

11

High-throughput

0.407

High

881824

HSP42
Heat shock protein 42

1

1

High-throughput

0.407

High

597504

EF3A
Elongation factor 3A

1

0

High-throughput

0.269

Low

801870

KSP1
Serine/threonine-protein kinase KSP1

1

0

High-throughput

0.261

Low

383790

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

433735

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

513108

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

613774

MDM10
Mitochondrial distribution and morphology protein 10

1

0

High-throughput

0.249

Low

753468

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

778427

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

881818

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

676154

MAS5
Mitochondrial protein import protein MAS5

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025