HitPredict

Interactor 1: RPB1 (P24928)
DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)
Gene: POLR2A

Interactor 2: WWP1 (Q9H0M0)
NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 2.3.2.26) (Atrophin-1-interacting protein 5) (AIP5) (HECT-type E3 ubiquitin transferase WWP1) (TGIF-interacting ubiquitin ligase 1) (Tiul1) (WW domain-containing protein 1)
Gene: WWP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1970 Hs			1 922
+	Hs
		624998 RPB1_HUMAN (1-1611): 0: 1858: 100.00		ITCH_HUMAN (1-922): 0: 884: 57.14
+	Hs
		125161 RPB1_HUMAN (1-1611): 0: 1858: 100.00		WWP2_HUMAN (1-922): 0: 841: 57.84
+	Mm
		444988 RPB1_MOUSE (1-1611): 0: 1858: 100.00		WWP2_MOUSE (1-922): 0: 841: 57.30
+	Hs
		624804 RPB1_HUMAN (1-1611): 0: 1858: 100.00		NEDD4_HUMAN (84-919): 0: 723: 33.52
+	Hs
		156002 RPC1_HUMAN (16-1484): 0: 1349: 33.36		NEDD4_HUMAN (84-919): 0: 723: 33.52
+	Hs
		625052 RPB1_HUMAN (1-1611): 0: 1858: 100.00		SMUF1_HUMAN (6-451): 5.28e-38: 154: 15.82
+	Sc
		375492 RPB1_YEAST (11-1592): 0: 1458: 48.49		TOM1_YEAST (439-921): 2.08e-156: 512: 31.81
+	Sc
		501407 RPA1_YEAST (11-1472): 0: 1134: 22.98		TOM1_YEAST (439-921): 2.08e-156: 512: 31.81
+	Sc
		375403 RPB1_YEAST (11-1592): 0: 1458: 48.49		RSP5_YEAST (16-424): 6.88e-44: 173: 20.05
+	Dm
		1374363 Q9VUH6_DROME (1418-1857): 4.26e-10: 67.6: 13.68		SUDX_DROME (14-922): 0: 832: 52.00