HitPredict

Interactor 1: CDK2 (P24941)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)
Gene: CDK2

Interactor 2: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	21319273
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 298 Hs			1 192
+	Hs
		436162 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45
+	Hs
		925197 CDK5_HUMAN (1-292): 1.62e-138: 394: 59.39		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		564480 CDK5_HUMAN (1-292): 1.62e-138: 394: 59.39		RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67
+	Hs
		545324 CDK5_HUMAN (1-292): 1.62e-138: 394: 59.39		RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19
+	Hs
		960329 CDK5_HUMAN (1-292): 1.62e-138: 394: 59.39		RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64
+	Hs
		892319 CDK5_HUMAN (1-292): 1.62e-138: 394: 59.39		RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19
+	Hs
		950926 CDK5_HUMAN (1-292): 1.62e-138: 394: 59.39		RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35
+	Hs
		893906 CDK5_HUMAN (1-292): 1.62e-138: 394: 59.39		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		900381 CDK5_HUMAN (1-292): 1.62e-138: 394: 59.39		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98