HitPredict

Interactor 1: APC (P25054)
Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5)
Gene: APC

Interactor 2: SPT13 (Q96N96)
Spermatogenesis-associated protein 13 (APC-stimulated guanine nucleotide exchange factor 2) (Asef2)
Gene: SPATA13

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.644

Property	Details
Experiments	17599059, 17145773
Identification Methods	pull down, anti bait coimmunoprecipitation, two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016477 - cell migration GO:0030027 - lamellipodium and 1 others more... GO:0032587 - ruffle membrane
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 2843 Hs			1 652
+	Hs
		626260 APC_HUMAN (1-2843): 0: 1316: 100.00		ARHG4_HUMAN (3-652): 1.93e-141: 429: 52.35
+	Rn
		88807 APC_RAT (1-2843): 0: 1222: 89.60		D3ZWB4_RAT (3-652): 2.03e-162: 500: 87.08
+	Hs
		257713 ANR17_HUMAN (1869-2843): 8.13e-62: 238: 14.08		ITSN2_HUMAN (137-631): 1.02e-86: 298: 18.58
+	Hs
		855816 TITIN_HUMAN (717-2430): 7.06e-29: 130: 7.55		VAV2_HUMAN (139-651): 8.2e-89: 297: 19.37
+	Hs
		1301019 CIC_HUMAN (722-2643): 2.1e-17: 92.4: 7.79		FARP1_HUMAN (8-646): 2.32e-90: 304: 16.59
+	Ce
		136804 UNC89_CAEEL (837-2156): 7.12e-24: 113: 12.70		VAV_CAEEL (200-635): 1.9e-79: 274: 20.41
+	Mm
		57869 ANK2_MOUSE (1056-2841): 1.1e-15: 86.5: 9.74		KALRN_MOUSE (224-624): 1.77e-59: 219: 20.39