HitPredict

Interactor 1: BRD2 (P25440)
Bromodomain-containing protein 2 (O27.1.1)
Gene: BRD2

Interactor 2: PRP4K (Q13523)
Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog)
Gene: PRP4K

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	31753913, 30554943
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0004674 - protein serine/threonine kinase activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 801 Hs			1 1007
+	Hs
		1037804 BRD3_HUMAN (53-764): 4.91e-124: 390: 56.56		PRP4K_HUMAN (1-1007): 1.03e-174: 538: 100.00
+	Hs
		244397 BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89		PRP4K_HUMAN (1-1007): 1.03e-174: 538: 100.00
+	Hs
		245029 BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89		CDK12_HUMAN (31-1005): 5.97e-121: 405: 15.92
+	Hs
		243796 BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89		CDK1_HUMAN (684-1005): 4.59e-124: 381: 25.00
+	Hs
		243949 BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89		CDK2_HUMAN (684-955): 5.29e-121: 373: 23.45
+	Hs
		244291 BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89		CDK5_HUMAN (684-1005): 2.54e-117: 363: 26.14
+	Hs
		998665 EP300_HUMAN (31-183): 5.52e-39: 159: 30.72		PRP4K_HUMAN (1-1007): 1.03e-174: 538: 100.00
+	Hs
		999150 EP300_HUMAN (31-183): 5.52e-39: 159: 30.72		CDK12_HUMAN (31-1005): 5.97e-121: 405: 15.92
+	Hs
		566375 EP300_HUMAN (31-183): 5.52e-39: 159: 30.72		KPCA_HUMAN (486-978): 6.58e-123: 391: 15.94
+	Hs
		408611 EP300_HUMAN (31-183): 5.52e-39: 159: 30.72		KPCB_HUMAN (486-990): 2.48e-122: 390: 15.01
+	Hs
		414892 EP300_HUMAN (31-183): 5.52e-39: 159: 30.72		CDK1_HUMAN (684-1005): 4.59e-124: 381: 25.00
+	Hs
		999248 EP300_HUMAN (31-183): 5.52e-39: 159: 30.72		DYR1B_HUMAN (618-1005): 4.81e-119: 380: 30.25
+	Hs
		625393 EP300_HUMAN (31-183): 5.52e-39: 159: 30.72		CDK2_HUMAN (684-955): 5.29e-121: 373: 23.45
+	Sc
		565752 GCN5_YEAST (275-456): 2.99e-40: 155: 26.63		PHO85_YEAST (686-1005): 4.97e-117: 363: 27.74
+	Hs
		625534 KAT2B_HUMAN (293-452): 1.59e-31: 134: 25.00		CDK2_HUMAN (684-955): 5.29e-121: 373: 23.45
+	Hs
		625533 KAT2A_HUMAN (293-452): 5.67e-30: 129: 24.38		CDK2_HUMAN (684-955): 5.29e-121: 373: 23.45
+	Hs
		164372 TRI66_HUMAN (2-527): 1.93e-51: 197: 16.79		DYR1A_HUMAN (677-1005): 2.55e-37: 152: 32.65
+	Hs
		999086 EP300_HUMAN (31-183): 5.52e-39: 159: 30.72		HIPK2_HUMAN (665-1003): 1.49e-39: 161: 32.59
+	Hs
		998682 EP300_HUMAN (31-183): 5.52e-39: 159: 30.72		DYR1A_HUMAN (677-1005): 2.55e-37: 152: 32.65
+	Ce
		712271 CBP1_CAEEL (5-191): 9.57e-30: 129: 23.19		MBK1_CAEEL (666-1006): 3.42e-40: 162: 33.52