HitPredict

Interactor 1: PSA1 (P25786)
Proteasome subunit alpha type-1 (30 kDa prosomal protein) (PROS-30) (Macropain subunit C2) (Multicatalytic endopeptidase complex subunit C2) (Proteasome component C2) (Proteasome nu chain)
Gene: PSMA1

Interactor 2: PSMD4 (P55036)
26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10) (26S proteasome regulatory subunit S5A) (Antisecretory factor 1) (AF) (ASF) (Multiubiquitin chain-binding protein)
Gene: PSMD4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	27114451, 30254168, 35271311, 24429290
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 263 Hs			1 377
+	Hs
		156262 PSA7_HUMAN (6-234): 9.99e-96: 282: 33.19		PSMD4_HUMAN (1-364): 0: 530: 100.00
+	Hs
		656185 PSA5_HUMAN (1-236): 5.66e-93: 275: 28.81		PSMD4_HUMAN (1-364): 0: 530: 100.00
+	Hs
		874058 PSA6_HUMAN (1-240): 1.64e-92: 274: 25.00		PSMD4_HUMAN (1-364): 0: 530: 100.00
+	Hs
		638097 PSA4_HUMAN (1-233): 4.82e-91: 271: 28.75		PSMD4_HUMAN (1-364): 0: 530: 100.00
+	Hs
		656250 PSA5_HUMAN (1-236): 5.66e-93: 275: 28.81		Q5VWC4_HUMAN (1-364): 0: 525: 99.18
+	Hs
		893687 PSA6_HUMAN (1-240): 1.64e-92: 274: 25.00		Q5VWC4_HUMAN (1-364): 0: 525: 99.18
+	Hs
		638147 PSA4_HUMAN (1-233): 4.82e-91: 271: 28.75		Q5VWC4_HUMAN (1-364): 0: 525: 99.18
+	Dm
		874043 Q9VK14_DROME (1-263): 3.32e-100: 295: 49.81		PSMD4_DROME (1-359): 6.74e-149: 428: 57.40
+	Sc
		756940 PSA6_YEAST (1-233): 3.26e-83: 250: 52.77		RPN10_YEAST (1-224): 1.27e-98: 295: 49.15