Protein: FLNC
Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin)

Gene: FLNC
Organism: Homo sapiens
Interactions: 190
UniProt ID: Q14315

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005856 - cytoskeleton
GO:0005886 - plasma membrane
GO:0005925 - focal adhesion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

278084

FLNB
Filamin-B

3

18

High-throughput

0.827

High

1125416

HSPB7
Heat shock protein beta-7

2

20

High-throughput

0.811

High

637509

FLNA
Filamin-A

2

17

High-throughput

0.754

High

1125334

FLNC
Filamin-C

1

16

Small-scale

0.716

High

1125335

MYPC2
Myosin-binding protein C, fast-type

1

20

High-throughput

0.698

High

212026

M3K13
Mitogen-activated protein kinase kinase kinase 13

1

7

High-throughput

0.691

High

1125368

FBLI1
Filamin-binding LIM protein 1

1

20

High-throughput

0.691

High

1125407

MYOZ1
Myozenin-1

3

11

Small-scale

0.674

High

1125371

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

3

20

High-throughput

0.667

High

1125341

HSPB2
Heat shock protein beta-2

1

18

High-throughput

0.656

High

1102516

SGCG
Gamma-sarcoglycan

2

2

Small-scale

0.642

High

1125374

SGCD
Delta-sarcoglycan

2

2

Small-scale

0.642

High

241671

PRKN
E3 ubiquitin-protein ligase parkin

3

10

High-throughput

0.640

High

992428

GBG3

2

3

High-throughput

0.628

High

1125343

PKHO1
Pleckstrin homology domain-containing family O member 1

2

1

High-throughput

0.628

High

1125377

RAB8B
Ras-related protein Rab-8B

2

6

High-throughput

0.628

High

1125347

OTUD1
OTU domain-containing protein 1

4

13

Small-scale

0.626

High

1125353

XIRP1
Xin actin-binding repeat-containing protein 1

2

1

Small-scale

0.625

High

1091396

ANK3
Ankyrin-3

2

11

Small-scale

0.624

High

1125392

TRI54
Tripartite motif-containing protein 54

2

20

Small-scale

0.620

High

362289

ABL1
Tyrosine-protein kinase ABL1

1

12

High-throughput

0.618

High

389359

FINC
Fibronectin

1

20

High-throughput

0.618

High

440557

FYN
Tyrosine-protein kinase Fyn

1

13

High-throughput

0.618

High

952817

ACTB
Actin, cytoplasmic 1

1

20

High-throughput

0.618

High

1125417

TES
Testin

1

20

High-throughput

0.618

High

1117898

BACD2
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

2

20

High-throughput

0.611

High

1125366

NT5C
5'(3')-deoxyribonucleotidase, cytosolic type

2

0

High-throughput

0.602

High

984405

RL30
Large ribosomal subunit protein eL30

2

2

High-throughput

0.601

High

1125337

MYPC3
Myosin-binding protein C, cardiac-type

1

20

Small-scale

0.590

High

1125351

RICTR
Rapamycin-insensitive companion of mTOR

2

5

High-throughput

0.584

High

1125419

FBW1B
F-box/WD repeat-containing protein 11

2

14

High-throughput

0.584

High

1062970

DDR1
Epithelial discoidin domain-containing receptor 1

1

16

Small-scale

0.575

High

1108538

TBB3
Tubulin beta-3 chain

1

6

High-throughput

0.575

High

1125355

TBA1A
Tubulin alpha-1A chain

1

7

High-throughput

0.575

High

1125395

NUAK2
NUAK family SNF1-like kinase 2

2

6

High-throughput

0.574

High

853889

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

1

12

Small-scale

0.573

High

1125349

FXL22
F-box and leucine-rich protein 22

1

3

Small-scale

0.573

High

193574

PDPK1
3-phosphoinositide-dependent protein kinase 1

2

3

High-throughput

0.571

High

563758

CFTR
Cystic fibrosis transmembrane conductance regulator

2

8

High-throughput

0.571

High

619793

VCAM1
Vascular cell adhesion protein 1

2

20

High-throughput

0.571

High

1125357

PHLB2
Pleckstrin homology-like domain family B member 2

1

20

Small-scale

0.561

High

187352

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

6

Small-scale

0.552

High

1125415

MYOTI
Myotilin

1

20

Small-scale

0.543

High

297349

DYSF
Dysferlin

1

5

High-throughput

0.541

High

445878

ENOA
Alpha-enolase

1

6

High-throughput

0.541

High

1125381

REPS1
RalBP1-associated Eps domain-containing protein 1

1

8

High-throughput

0.541

High

529794

TAU
Microtubule-associated protein tau

1

14

High-throughput

0.536

High

851313

PRS6B
26S proteasome regulatory subunit 6B

1

2

High-throughput

0.536

High

1024355

S25A3
Solute carrier family 25 member 3

1

2

High-throughput

0.536

High

1032307

OTUD4
OTU domain-containing protein 4

1

8

High-throughput

0.536

High

1052013

CALD1
Caldesmon

1

20

High-throughput

0.536

High

1113095

CUL3
Cullin-3

1

18

High-throughput

0.536

High

1125338

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

8

High-throughput

0.536

High

1125356

ANS1B
Ankyrin repeat and sterile alpha motif domain-containing protein 1B

1

20

High-throughput

0.536

High

1125365

ARRD2
Arrestin domain-containing protein 2

1

8

High-throughput

0.536

High

1125373

RPGF5
Rap guanine nucleotide exchange factor 5

1

3

High-throughput

0.536

High

1125385

KKCC2
Calcium/calmodulin-dependent protein kinase kinase 2

1

5

High-throughput

0.536

High

1125396

P63
Tumor protein 63

1

5

Small-scale

0.536

High

1125401

PKHG2
Pleckstrin homology domain-containing family G member 2

1

16

High-throughput

0.536

High

1125402

PHAX
Phosphorylated adapter RNA export protein

1

1

High-throughput

0.536

High

1125413

SMOX
Spermine oxidase

1

2

High-throughput

0.536

High

1125420

NUDT5
ADP-sugar pyrophosphatase

1

2

High-throughput

0.536

High

1125426

WIPI2
WD repeat domain phosphoinositide-interacting protein 2

1

18

High-throughput

0.536

High

105930

APRIO
Alternative prion protein

2

9

High-throughput

0.533

High

372017

MYC
Myc proto-oncogene protein

2

14

High-throughput

0.533

High

1125414

KCND2
A-type voltage-gated potassium channel KCND2

1

6

Small-scale

0.527

High

1125421

SYNP2
Synaptopodin-2

1

20

Small-scale

0.527

High

635590

FILA
Filaggrin

1

10

High-throughput

0.515

High

656123

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

7

High-throughput

0.515

High

1125344

H2B2F
Histone H2B type 2-F

1

15

High-throughput

0.515

High

1125369

RASF5
Ras association domain-containing protein 5

1

0

High-throughput

0.513

High

1125389

LRC61
Leucine-rich repeat-containing protein 61

1

0

High-throughput

0.513

High

1125379

TRI63
E3 ubiquitin-protein ligase TRIM63

1

20

High-throughput

0.508

High

62767

XIRP2
Xin actin-binding repeat-containing protein 2

1

1

Small-scale

0.501

High

635075

CAN3
Calpain-3

1

10

Small-scale

0.501

High

955162

CDC42
Cell division control protein 42 homolog

1

17

High-throughput

0.501

High

1125384

DOCK6
Dedicator of cytokinesis protein 6

1

0

High-throughput

0.493

High

139061

LAD1
Ladinin-1

1

15

High-throughput

0.489

High

1091046

FOXF1
Forkhead box protein F1

1

4

High-throughput

0.489

High

1125391

RTF2
Replication termination factor 2

1

1

High-throughput

0.489

High

1125405

TANC2
Protein TANC2

1

18

High-throughput

0.489

High

225589

AAKB2
5'-AMP-activated protein kinase subunit beta-2

1

6

Small-scale

0.481

High

1125340

KS6A2
Ribosomal protein S6 kinase alpha-2

1

3

High-throughput

0.481

High

1125393

TRI55
Tripartite motif-containing protein 55

1

20

High-throughput

0.481

High

1125399

WNK1
Serine/threonine-protein kinase WNK1

1

12

High-throughput

0.481

High

1125418

UBP25
Ubiquitin carboxyl-terminal hydrolase 25

1

8

Small-scale

0.481

High

125454

LEG9
Galectin-9

1

11

High-throughput

0.479

High

157367

CTRO
Citron Rho-interacting kinase

1

16

High-throughput

0.479

High

159349

DVL1
Segment polarity protein dishevelled homolog DVL-1

1

20

High-throughput

0.479

High

176194

PER2
Period circadian protein homolog 2

1

5

Small-scale

0.479

High

211566

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

4

Small-scale

0.479

High

223034

PRC1
Protein regulator of cytokinesis 1

1

17

High-throughput

0.479

High

272167

OBSL1
Obscurin-like protein 1

1

20

High-throughput

0.479

High

297603

PIAS1
E3 SUMO-protein ligase PIAS1

1

7

High-throughput

0.479

High

330962

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

345809

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

6

High-throughput

0.479

High

447013

NPM
Nucleophosmin

1

4

High-throughput

0.479

High

535053

BIP
Endoplasmic reticulum chaperone BiP

1

16

High-throughput

0.479

High

537151

HSP7C
Heat shock cognate 71 kDa protein

1

8

High-throughput

0.479

High

593996

NCK1
SH2/SH3 adapter protein NCK1

1

20

High-throughput

0.479

High

603976

CXA1
Gap junction alpha-1 protein

1

8

Small-scale

0.479

High

619058

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

6

High-throughput

0.479

High

667847

CDK2
Cyclin-dependent kinase 2

1

8

High-throughput

0.479

High

699747

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

8

High-throughput

0.479

High

714115

PML
Protein PML

1

17

High-throughput

0.479

High

766549

PHB1
Prohibitin 1

1

9

High-throughput

0.479

High

799110

BRCA1
Breast cancer type 1 susceptibility protein

1

15

High-throughput

0.479

High

855623

CRK
Adapter molecule crk

1

20

High-throughput

0.479

High

861608

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

14

Small-scale

0.479

High

867126

CAPZB
F-actin-capping protein subunit beta

1

5

High-throughput

0.479

High

888061

MCM2
DNA replication licensing factor MCM2

1

17

High-throughput

0.479

High

904709

MECP2
Methyl-CpG-binding protein 2

1

11

High-throughput

0.479

High

929947

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

11

High-throughput

0.479

High

986423

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

6

High-throughput

0.479

High

987638

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.479

High

1004560

RNF4
E3 ubiquitin-protein ligase RNF4

1

4

High-throughput

0.479

High

1040801

MECOM
Histone-lysine N-methyltransferase MECOM

1

3

High-throughput

0.479

High

1050791

PTN12
Tyrosine-protein phosphatase non-receptor type 12

1

3

High-throughput

0.479

High

1051228

KPCZ
Protein kinase C zeta type

1

6

High-throughput

0.479

High

1114811

CUL4A
Cullin-4A

1

18

High-throughput

0.479

High

1115648

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

14

High-throughput

0.479

High

1125339

KIF14
Kinesin-like protein KIF14

1

9

High-throughput

0.479

High

1125350

CDC73
Parafibromin

1

6

High-throughput

0.479

High

1125352

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

20

High-throughput

0.479

High

1125364

DTX3
Probable E3 ubiquitin-protein ligase DTX3

1

4

Small-scale

0.479

High

1125367

MYOZ3
Myozenin-3

1

11

Small-scale

0.479

High

1125370

SSH1
Protein phosphatase Slingshot homolog 1

1

4

High-throughput

0.479

High

1125372

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

8

High-throughput

0.479

High

1125378

IGSF8
Immunoglobulin superfamily member 8

1

20

High-throughput

0.479

High

1125380

CHM4C
Charged multivesicular body protein 4c

1

18

High-throughput

0.479

High

1125382

SPDLY
Protein Spindly

1

19

High-throughput

0.479

High

1125383

RNF31
E3 ubiquitin-protein ligase RNF31

1

7

High-throughput

0.479

High

1125387

ANM1
Protein arginine N-methyltransferase 1

1

6

High-throughput

0.479

High

1125388

MEP50
Methylosome protein WDR77

1

18

High-throughput

0.479

High

1125390

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

17

High-throughput

0.479

High

1125397

CHM4B
Charged multivesicular body protein 4b

1

18

High-throughput

0.479

High

1125400

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

1125403

ECT2
Protein ECT2

1

19

High-throughput

0.479

High

1125408

MYOZ2
Myozenin-2

1

11

Small-scale

0.479

High

1125409

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

High-throughput

0.479

High

1125410

ANLN
Anillin

1

11

High-throughput

0.479

High

1125411

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

9

High-throughput

0.479

High

1125412

RAD18
E3 ubiquitin-protein ligase RAD18

1

3

High-throughput

0.479

High

1125422

CARD8
Caspase recruitment domain-containing protein 8

1

1

High-throughput

0.479

High

1125425

RPGF2
Rap guanine nucleotide exchange factor 2

1

3

High-throughput

0.479

High

353327

AGR2
Anterior gradient protein 2 homolog

1

7

High-throughput

0.470

High

418980

H2A1B
Histone H2A type 1-B/E

1

6

High-throughput

0.470

High

335283

TFIP8
Tumor necrosis factor alpha-induced protein 8

1

0

High-throughput

0.458

High

939623

BID
BH3-interacting domain death agonist

1

0

Small-scale

0.458

High

1125363

NAT8L
N-acetylaspartate synthetase

1

0

High-throughput

0.458

High

1125386

PI51A
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

1

0

High-throughput

0.458

High

176347

SYNEM
Synemin

1

12

Small-scale

0.457

High

669171

ADA1D
Alpha-1D adrenergic receptor

1

8

Small-scale

0.457

High

770732

ADA1A
Alpha-1A adrenergic receptor

1

6

Small-scale

0.457

High

770824

ADA1B
Alpha-1B adrenergic receptor

1

7

Small-scale

0.457

High

993567

UBC9
SUMO-conjugating enzyme UBC9

1

3

High-throughput

0.457

High

1125404

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

14

High-throughput

0.457

High

404789

PRIO
Major prion protein

1

3

High-throughput

0.445

High

934606

TERA
Transitional endoplasmic reticulum ATPase

1

8

High-throughput

0.445

High

1125336

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

10

High-throughput

0.445

High

1125345

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

8

High-throughput

0.445

High

1125360

KIBRA
Protein KIBRA

1

15

High-throughput

0.445

High

1125362

RYBP
RING1 and YY1-binding protein

1

4

High-throughput

0.445

High

1125394

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

16

High-throughput

0.445

High

1125398

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

16

High-throughput

0.445

High

1125424

SHLB1
Endophilin-B1

1

14

High-throughput

0.445

High

588686

RFA2
Replication protein A 32 kDa subunit

1

8

High-throughput

0.437

High

695445

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.437

High

755917

MCM5
DNA replication licensing factor MCM5

1

16

High-throughput

0.437

High

768180

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

1125342

FBX43
F-box only protein 43

1

2

Small-scale

0.437

High

1125358

MGDP1
Magnesium-dependent phosphatase 1

1

3

High-throughput

0.437

High

1125376

ATOH1
Transcription factor ATOH1

1

4

Small-scale

0.437

High

1125406

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

3

High-throughput

0.437

High

1125423

SNX24
Sorting nexin-24

1

1

High-throughput

0.437

High

1063043

S20A2
Sodium-dependent phosphate transporter 2

1

0

High-throughput

0.426

High

827402

MLH1
DNA mismatch repair protein Mlh1

1

1

Small-scale

0.417

High

47874

A0AUL9
ATG2A protein

1

1

High-throughput

0.407

High

429880

JUN
Transcription factor Jun

1

7

High-throughput

0.407

High

653314

HEMH
Ferrochelatase, mitochondrial

1

5

High-throughput

0.407

High

1125375

ESR2
Estrogen receptor beta

1

20

High-throughput

0.407

High

321910

FRYL
Protein furry homolog-like

2

0

High-throughput

0.328

High

69869

ERI2
ERI1 exoribonuclease 2

2

0

High-throughput

0.318

High

1125361

OFCC1
Orofacial cleft 1 candidate gene 1 protein

2

0

High-throughput

0.288

High

1125346

CF141
Uncharacterized protein C6orf141

1

0

High-throughput

0.279

Low

1125348

SPRY7
SPRY domain-containing protein 7

1

0

High-throughput

0.279

Low

1125354

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

1

0

High-throughput

0.279

Low

1125359

MFN1
Mitofusin-1

1

0

High-throughput

0.279

Low

213712

PAX4
Paired box protein Pax-4

1

0

High-throughput

0.269

Low


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Last updated: 11Aug2025