HitPredict

Interactor 1: FLNA (P21333)
Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)
Gene: FLNA

Interactor 2: RHG24 (Q8N264)
Rho GTPase-activating protein 24 (Filamin-A-associated RhoGAP) (FilGAP) (RAC1- and CDC42-specific GTPase-activating protein of 72 kDa) (RC-GAP72) (Rho-type GTPase-activating protein 24) (RhoGAP of 73 kDa) (Sarcoma antigen NY-SAR-88) (p73RhoGAP)
Gene: ARHGAP24

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.626

Property	Details
Experiments	21926999, 16862148
Identification Methods	anti tag coimmunoprecipitation, two hybrid, pull down, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005925 - focal adhesion
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 2647 Hs			1 748
+	Hs
		637559 FLNA_HUMAN (1-2647): 0: 2776: 100.00		RHG21_HUMAN (50-746): 2.12e-96: 330: 15.95
+	Hs
		277980 FLNB_HUMAN (28-2647): 0: 2710: 69.63		FA13A_HUMAN (110-676): 2.82e-70: 250: 19.83
+	Hs
		555716 ACTN1_HUMAN (21-459): 1.48e-117: 398: 24.18		RHG24_HUMAN (1-748): 0: 647: 100.00
+	Hs
		224745 ACTN4_HUMAN (23-459): 3.26e-115: 392: 24.06		RHG24_HUMAN (1-748): 0: 647: 100.00
+	Hs
		224723 ACTN4_HUMAN (23-459): 3.26e-115: 392: 24.06		RHG29_HUMAN (111-694): 3.01e-77: 273: 15.27
+	Ce
		758616 Q9XVU8_CAEEL (10-349): 4.32e-115: 391: 24.50		PAC1_CAEEL (68-725): 5.05e-70: 252: 15.48
+	Ce
		758612 Q23158_CAEEL (23-268): 6.23e-105: 362: 32.93		PAC1_CAEEL (68-725): 5.05e-70: 252: 15.48