HitPredict

Interactor 1: PSA3 (P25788)
Proteasome subunit alpha type-3 (Macropain subunit C8) (Multicatalytic endopeptidase complex subunit C8) (Proteasome component C8)
Gene: PSMA3

Interactor 2: PSMD6 (Q15008)
26S proteasome non-ATPase regulatory subunit 6 (26S proteasome regulatory subunit RPN7) (26S proteasome regulatory subunit S10) (Breast cancer-associated protein SGA-113M) (Phosphonoformate immuno-associated protein 4) (Proteasome regulatory particle subunit p44S10) (p42A)
Gene: PSMD6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35271311, 17353931
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 255 Hs			1 389
+	Dm
		1358528 PSA3_DROME (1-252): 1.3e-108: 315: 57.54		PSMD6_DROME (1-389): 2.36e-125: 368: 70.18
+	Hs
		656232 PSA5_HUMAN (1-239): 4.52e-96: 283: 31.97		PSMD6_HUMAN (1-389): 5.58e-137: 397: 100.00
+	Hs
		893673 PSA6_HUMAN (4-242): 1.96e-95: 281: 29.34		PSMD6_HUMAN (1-389): 5.58e-137: 397: 100.00
+	Hs
		638133 PSA4_HUMAN (4-236): 5.31e-94: 278: 27.43		PSMD6_HUMAN (1-389): 5.58e-137: 397: 100.00
+	Hs
		156291 PSA7_HUMAN (7-237): 4.58e-93: 275: 31.76		PSMD6_HUMAN (1-389): 5.58e-137: 397: 100.00
+	Dm
		1278633 PSA5_DROME (1-240): 1.81e-96: 284: 27.94		PSMD6_DROME (1-389): 2.36e-125: 368: 70.18
+	Hs
		893660 PSA6_HUMAN (4-242): 1.96e-95: 281: 29.34		CSN1_HUMAN (12-389): 3.49e-93: 289: 20.25
+	Dm
		1180717 PSA3_DROME (1-252): 1.3e-108: 315: 57.54		PSD11_DROME (7-387): 4.3e-77: 246: 13.32
+	Hs
		893638 PSA6_HUMAN (4-242): 1.96e-95: 281: 29.34		CSN2_HUMAN (22-388): 5.37e-90: 280: 13.67
+	Sc
		689209 PSA5_YEAST (1-255): 3.35e-94: 278: 32.57		RPN7_YEAST (11-389): 3.41e-86: 269: 35.47
+	Zm
		6694 A0A1D6N969_MAIZE (1-250): 1.04e-96: 285: 59.30		A0A1D6E9U0_MAIZE (7-388): 3.33e-78: 249: 11.49
+	Dm
		1180708 PSA5_DROME (1-240): 1.81e-96: 284: 27.94		PSD11_DROME (7-387): 4.3e-77: 246: 13.32
+	Hs
		121689 PSA5_HUMAN (1-239): 4.52e-96: 283: 31.97		PSD11_HUMAN (3-387): 8.54e-77: 245: 11.03
+	Hs
		121719 PSA6_HUMAN (4-242): 1.96e-95: 281: 29.34		PSD11_HUMAN (3-387): 8.54e-77: 245: 11.03
+	Hs
		121685 PSA4_HUMAN (4-236): 5.31e-94: 278: 27.43		PSD11_HUMAN (3-387): 8.54e-77: 245: 11.03
+	Hs
		121635 PSA7_HUMAN (7-237): 4.58e-93: 275: 31.76		PSD11_HUMAN (3-387): 8.54e-77: 245: 11.03
+	Sc
		597279 PSA7_YEAST (1-246): 4.1e-111: 322: 51.20		RPN6_YEAST (30-389): 1.53e-56: 192: 12.57
+	Sc
		689219 PSA5_YEAST (1-255): 3.35e-94: 278: 32.57		RPN6_YEAST (30-389): 1.53e-56: 192: 12.57
+	Sp
		1013777 PSA4_SCHPO (6-189): 3.96e-35: 127: 40.00		RPN7_SCHPO (9-387): 7.57e-96: 293: 42.78
+	Sp
		1013779 PSA4_SCHPO (6-189): 3.96e-35: 127: 40.00		RPN6_SCHPO (5-386): 3.53e-81: 256: 13.80