Protein: RASA1
Ras GTPase-activating protein 1 (GAP) (GTPase-activating protein) (RasGAP) (Ras p21 protein activator) (p120GAP)

Gene: RASA1
Organism: Homo sapiens
Interactions: 144
UniProt ID: P20936

Gene Ontology (top 5):
GO:0000281 - mitotic cytokinesis
GO:0001570 - vasculogenesis
GO:0001726 - ruffle
GO:0001784 - phosphotyrosine residue binding
GO:0001953 - negative regulation of cell-matrix adhesion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

635746

DOK1
Docking protein 1

9

20

Small-scale

0.966

High

374396

RASH
GTPase HRas

5

20

Small-scale

0.927

High

484049

PGFRB
Platelet-derived growth factor receptor beta

6

20

Small-scale

0.921

High

635752

RHG35
Rho GTPase-activating protein 35

4

17

Small-scale

0.890

High

362758

EGFR
Epidermal growth factor receptor

4

20

Small-scale

0.888

High

410611

ERBB2
Receptor tyrosine-protein kinase erbB-2

3

20

High-throughput

0.857

High

593904

NCK1
SH2/SH3 adapter protein NCK1

2

20

Small-scale

0.838

High

635745

RHG07
Rho GTPase-activating protein 7

2

14

Small-scale

0.827

High

618971

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

3

5

Small-scale

0.827

High

635678

EPHB2
Ephrin type-B receptor 2

2

20

Small-scale

0.812

High

635717

FAK2
Protein-tyrosine kinase 2-beta

2

20

Small-scale

0.806

High

373769

RASN
GTPase NRas

2

20

Small-scale

0.793

High

635673

ERBB3
Receptor tyrosine-protein kinase erbB-3

2

20

High-throughput

0.778

High

635720

ERBB4
Receptor tyrosine-protein kinase erbB-4

2

20

High-throughput

0.778

High

635716

GAB1
GRB2-associated-binding protein 1

2

20

Small-scale

0.777

High

193206

SOCS1
Suppressor of cytokine signaling 1

2

20

Small-scale

0.776

High

557085

SRC
Proto-oncogene tyrosine-protein kinase Src

2

20

Small-scale

0.768

High

155908

SOCS3
Suppressor of cytokine signaling 3

1

20

Small-scale

0.757

High

249717

DOK2
Docking protein 2

2

20

Small-scale

0.754

High

439637

INSR
Insulin receptor

2

20

Small-scale

0.754

High

635711

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

7

7

Small-scale

0.739

High

179141

ARC1B
Actin-related protein 2/3 complex subunit 1B

2

4

High-throughput

0.737

High

635675

S10A4
Protein S100-A4

2

8

High-throughput

0.737

High

635719

ACAP2
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2

2

20

High-throughput

0.737

High

635747

COR1B
Coronin-1B

2

12

High-throughput

0.737

High

635759

COR1C
Coronin-1C

2

12

High-throughput

0.737

High

465403

IGF1R
Insulin-like growth factor 1 receptor

1

20

Small-scale

0.734

High

473366

HCK
Tyrosine-protein kinase HCK

1

20

Small-scale

0.724

High

635699

EPHB3
Ephrin type-B receptor 3

1

20

Small-scale

0.724

High

635707

RACK1
Small ribosomal subunit protein RACK1

1

8

Small-scale

0.724

High

169945

AURKA
Aurora kinase A

1

10

High-throughput

0.698

High

224083

BUB1
Mitotic checkpoint serine/threonine-protein kinase BUB1

1

16

High-throughput

0.698

High

635683

BMR1A
Bone morphogenetic protein receptor type-1A

1

4

High-throughput

0.698

High

635689

DCC
Netrin receptor DCC

1

6

High-throughput

0.698

High

635714

PTPRJ
Receptor-type tyrosine-protein phosphatase eta

1

13

High-throughput

0.698

High

635722

STK11
Serine/threonine-protein kinase STK11

1

2

High-throughput

0.698

High

471984

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.692

High

532045

KIT
Mast/stem cell growth factor receptor Kit

1

20

High-throughput

0.692

High

439945

LCK
Tyrosine-protein kinase Lck

1

20

Small-scale

0.647

High

541334

FGFR1
Fibroblast growth factor receptor 1

1

20

Small-scale

0.647

High

635682

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

20

Small-scale

0.647

High

635685

CSK
Tyrosine-protein kinase CSK

1

20

Small-scale

0.647

High

635730

ABI1
Abl interactor 1

1

20

Small-scale

0.647

High

635688

HD
Huntingtin

2

4

Small-scale

0.634

High

635731

AN36B
Ankyrin repeat domain-containing protein 36B

1

10

High-throughput

0.618

High

348053

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

20

Small-scale

0.618

High

362158

ABL1
Tyrosine-protein kinase ABL1

1

20

Small-scale

0.618

High

375171

RASK
GTPase KRas

1

20

Small-scale

0.618

High

411341

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

462984

YES
Tyrosine-protein kinase Yes

1

20

Small-scale

0.618

High

593272

PGFRA
Platelet-derived growth factor receptor alpha

1

20

Small-scale

0.618

High

635671

RASA1
Ras GTPase-activating protein 1

1

15

High-throughput

0.618

High

635677

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.618

High

635681

VGFR2
Vascular endothelial growth factor receptor 2

1

20

Small-scale

0.618

High

635690

ZAP70
Tyrosine-protein kinase ZAP-70

1

20

Small-scale

0.618

High

635706

GRB2
Growth factor receptor-bound protein 2

1

20

Small-scale

0.618

High

635727

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.618

High

635741

SPSB1
SPRY domain-containing SOCS box protein 1

1

12

Small-scale

0.618

High

635700

EPHA4
Ephrin type-A receptor 4

1

20

High-throughput

0.590

High

635710

CAV1
Caveolin-1

2

8

Small-scale

0.585

High

178075

FYB1
FYN-binding protein 1

1

10

Small-scale

0.575

High

635712

DDR1
Epithelial discoidin domain-containing receptor 1

1

20

Small-scale

0.575

High

123584

MYO1C
Unconventional myosin-Ic

2

16

High-throughput

0.571

High

143553

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

2

6

High-throughput

0.571

High

192689

ARPC5
Actin-related protein 2/3 complex subunit 5

2

2

High-throughput

0.571

High

240055

KPRB
Phosphoribosyl pyrophosphate synthase-associated protein 2

2

3

High-throughput

0.571

High

318263

MYO1D
Unconventional myosin-Id

2

18

High-throughput

0.571

High

415346

HSPB1
Heat shock protein beta-1

2

4

High-throughput

0.571

High

424768

ADT2
ADP/ATP translocase 2

2

7

High-throughput

0.571

High

536485

HSP7C
Heat shock cognate 71 kDa protein

2

7

High-throughput

0.571

High

549533

PRPS2
Ribose-phosphate pyrophosphokinase 2

2

3

High-throughput

0.571

High

577612

PLAK
Junction plakoglobin

2

11

High-throughput

0.571

High

635672

FLNA
Filamin-A

2

14

High-throughput

0.571

High

635684

HSPA9
Stress-70 protein, mitochondrial

2

15

High-throughput

0.571

High

635691

CAPZB
F-actin-capping protein subunit beta

2

2

High-throughput

0.571

High

635693

FAS
Fatty acid synthase

2

2

High-throughput

0.571

High

635696

6PGD
6-phosphogluconate dehydrogenase, decarboxylating

2

1

High-throughput

0.571

High

635697

CAZA1
F-actin-capping protein subunit alpha-1

2

3

High-throughput

0.571

High

635701

ARPC4
Actin-related protein 2/3 complex subunit 4

2

2

High-throughput

0.571

High

635702

ACTB
Actin, cytoplasmic 1

2

14

High-throughput

0.571

High

635703

PRPS1
Ribose-phosphate pyrophosphokinase 1

2

3

High-throughput

0.571

High

635708

ACTG
Actin, cytoplasmic 2

2

14

High-throughput

0.571

High

635709

AKA12
A-kinase anchor protein 12

2

12

High-throughput

0.571

High

635713

TWF1
Twinfilin-1

2

8

High-throughput

0.571

High

635718

KPRA
Phosphoribosyl pyrophosphate synthase-associated protein 1

2

3

High-throughput

0.571

High

635724

DREB
Drebrin

2

13

High-throughput

0.571

High

635739

HS105
Heat shock protein 105 kDa

2

11

High-throughput

0.571

High

635750

RM44
Large ribosomal subunit protein mL44

2

1

High-throughput

0.571

High

635751

MAGE1
Melanoma-associated antigen E1

2

3

High-throughput

0.571

High

635760

DRG1
Developmentally-regulated GTP-binding protein 1

2

1

High-throughput

0.571

High

635762

RM42
Large ribosomal subunit protein mL42

2

1

High-throughput

0.571

High

635763

NS1BP
Influenza virus NS1A-binding protein

2

2

High-throughput

0.571

High

635695

CAV2
Caveolin-2

1

8

Small-scale

0.561

High

635743

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

3

Small-scale

0.561

High

635744

GMCL1
Germ cell-less protein-like 1

2

4

High-throughput

0.553

High

321078

PLPHP
Pyridoxal phosphate homeostasis protein

2

0

High-throughput

0.547

High

528735

MGST1
Microsomal glutathione S-transferase 1

2

0

High-throughput

0.547

High

635704

RUXE
Small nuclear ribonucleoprotein E

2

0

High-throughput

0.547

High

635705

RUXF
Small nuclear ribonucleoprotein F

2

0

High-throughput

0.547

High

635735

MTMRE
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14

2

0

High-throughput

0.547

High

635736

OLIG1
Oligodendrocyte transcription factor 1

2

2

High-throughput

0.542

High

442585

RB
Retinoblastoma-associated protein

1

1

High-throughput

0.541

High

635674

APC
Adenomatous polyposis coli protein

1

11

High-throughput

0.541

High

635698

PMS2
Mismatch repair endonuclease PMS2

1

1

High-throughput

0.541

High

635721

SMAD2
Mothers against decapentaplegic homolog 2

1

1

High-throughput

0.541

High

466001

ANXA6
Annexin A6

1

6

Small-scale

0.536

High

519737

ANDR
Androgen receptor

1

11

High-throughput

0.536

High

438927

CD5
T-cell surface glycoprotein CD5

1

2

Small-scale

0.536

High

635694

ACADV
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

2

2

High-throughput

0.521

High

635754

TMOD3
Tropomodulin-3

2

4

High-throughput

0.521

High

353844

BCL10
B-cell lymphoma/leukemia 10

1

0

High-throughput

0.518

High

412930

CPNS1
Calpain small subunit 1

1

13

Small-scale

0.515

High

557855

XRCC6
X-ray repair cross-complementing protein 6

1

3

High-throughput

0.508

High

635729

TRM2A
tRNA

1

1

High-throughput

0.508

High

421488

A4
Amyloid-beta precursor protein

1

7

High-throughput

0.501

High

635756

SL9A2
Sodium/hydrogen exchanger 2

1

3

Small-scale

0.501

High

635757

MLH3
DNA mismatch repair protein Mlh3

1

1

High-throughput

0.494

High

635686

EIF1
Eukaryotic translation initiation factor 1

1

0

High-throughput

0.486

High

635737

BBS10
BBSome complex assembly protein BBS10

1

0

High-throughput

0.486

High

635687

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

17

High-throughput

0.481

High

221315

SPY1
Protein sprouty homolog 1

1

10

Small-scale

0.479

High

605235

ATF7
Cyclic AMP-dependent transcription factor ATF-7

1

5

High-throughput

0.479

High

635680

SDC2
Syndecan-2

1

3

Small-scale

0.479

High

635692

PAXI
Paxillin

1

11

Small-scale

0.479

High

635715

G3BP1
Ras GTPase-activating protein-binding protein 1

1

4

Small-scale

0.479

High

635726

RNF43
E3 ubiquitin-protein ligase RNF43

1

8

High-throughput

0.479

High

635748

RIOK1
Serine/threonine-protein kinase RIO1

1

3

High-throughput

0.479

High

635723

EZH2
Histone-lysine N-methyltransferase EZH2

1

5

High-throughput

0.464

High

635753

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

Small-scale

0.458

High

635738

TSC1
Hamartin

1

20

Small-scale

0.457

High

635733

ARF
Tumor suppressor ARF

1

0

High-throughput

0.438

High

635676

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.437

High

635732

FBXL6
F-box/LRR-repeat protein 6

1

1

High-throughput

0.437

High

635725

RM02
Large ribosomal subunit protein uL2m

2

0

High-throughput

0.298

High

635728

RM10
Large ribosomal subunit protein uL10m

2

0

High-throughput

0.298

High

635740

RM24
Large ribosomal subunit protein uL24m

2

0

High-throughput

0.298

High

635742

RM53
Large ribosomal subunit protein mL53

2

0

High-throughput

0.298

High

635749

RM18
Large ribosomal subunit protein uL18m

2

0

High-throughput

0.298

High

635755

RM15
Large ribosomal subunit protein uL15m

2

0

High-throughput

0.298

High

635758

DPP2
Dipeptidyl peptidase 2

2

0

High-throughput

0.298

High

635761

RM11
Large ribosomal subunit protein uL11m

2

0

High-throughput

0.298

High

635679

KAIN
Kallistatin

1

0

High-throughput

0.265

Low

635734

ZN579
Zinc finger protein 579

1

0

High-throughput

0.265

Low


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Last updated: 11Aug2025