HitPredict

Interactor 1: PSA4 (P25789)
Proteasome subunit alpha type-4 (Macropain subunit C9) (Multicatalytic endopeptidase complex subunit C9) (Proteasome component C9) (Proteasome subunit L)
Gene: PSMA4

Interactor 2: PSMD1 (Q99460)
26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit RPN2) (26S proteasome regulatory subunit S1) (26S proteasome subunit p112)
Gene: PSMD1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 261 Hs			1 953
+	Hs
		108952 H0YKT8_HUMAN (25-205): 1.07e-132: 374: 100.00		PSMD1_HUMAN (1-953): 0: 1310: 100.00
+	Hs
		893734 PSA6_HUMAN (2-244): 3.23e-92: 273: 31.84		PSMD1_HUMAN (1-953): 0: 1310: 100.00
+	Hs
		637529 PSA1_HUMAN (4-259): 2.5e-91: 272: 28.57		PSMD1_HUMAN (1-953): 0: 1310: 100.00
+	Hs
		156342 PSA7_HUMAN (5-238): 2.84e-91: 271: 33.19		PSMD1_HUMAN (1-953): 0: 1310: 100.00
+	Hs
		688 PSA4_HUMAN (1-237): 2.4e-98: 289: 100.00		A0A087WW66_HUMAN (1-953): 0: 1204: 93.10
+	Hs
		699 PSA6_HUMAN (2-244): 3.23e-92: 273: 31.84		A0A087WW66_HUMAN (1-953): 0: 1204: 93.10
+	Hs
		685 PSA1_HUMAN (4-259): 2.5e-91: 272: 28.57		A0A087WW66_HUMAN (1-953): 0: 1204: 93.10
+	Dm
		574031 PSA4_DROME (1-242): 9.91e-93: 275: 72.25		PSMD1_DROME (2-933): 0: 1114: 61.64
+	Dm
		1278636 PSA5_DROME (3-241): 6.79e-89: 265: 32.11		PSMD1_DROME (2-933): 0: 1114: 61.64
+	Sc
		619340 PSA3_YEAST (2-245): 2.67e-89: 267: 52.03		RPN2_YEAST (2-953): 0: 984: 40.26
+	Sc
		693311 PSA4_YEAST (3-240): 1.72e-87: 262: 32.37		RPN2_YEAST (2-953): 0: 984: 40.26
+	Hs
		108943 H0YKT8_HUMAN (25-205): 1.07e-132: 374: 100.00		PSMD2_HUMAN (8-796): 0: 802: 18.73
+	Hs
		638122 PSA4_HUMAN (1-237): 2.4e-98: 289: 100.00		PSMD2_HUMAN (8-796): 0: 802: 18.73
+	Hs
		893662 PSA6_HUMAN (2-244): 3.23e-92: 273: 31.84		PSMD2_HUMAN (8-796): 0: 802: 18.73
+	Hs
		637407 PSA1_HUMAN (4-259): 2.5e-91: 272: 28.57		PSMD2_HUMAN (8-796): 0: 802: 18.73
+	Hs
		156281 PSA7_HUMAN (5-238): 2.84e-91: 271: 33.19		PSMD2_HUMAN (8-796): 0: 802: 18.73
+	Dm
		574050 PSA4_DROME (1-242): 9.91e-93: 275: 72.25		Q9VW54_DROME (12-796): 0: 702: 16.86
+	Dm
		1278652 PSA5_DROME (3-241): 6.79e-89: 265: 32.11		Q9VW54_DROME (12-796): 0: 702: 16.86
+	Sp
		953201 PSA3_SCHPO (1-247): 3.47e-95: 281: 52.21		RPN1_SCHPO (8-794): 0: 666: 18.03
+	Sc
		619357 PSA3_YEAST (2-245): 2.67e-89: 267: 52.03		RPN1_YEAST (8-604): 4.59e-149: 468: 15.96