HitPredict

Interactor 1: DNMT1 (P26358)
DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT)
Gene: DNMT1

Interactor 2: CBX5 (P45973)
Chromobox protein homolog 5 (Antigen p25) (Heterochromatin protein 1 homolog alpha) (HP1 alpha)
Gene: CBX5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	12867029, 17470536
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Chromo~DNA_methylase
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005721 - pericentric heterochromatin
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1616 Hs			1 191
+	Hs
		641207 DNMT1_HUMAN (1-1616): 0: 1717: 100.00		CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22
+	Hs
		641192 DNMT1_HUMAN (1-1616): 0: 1717: 100.00		CBX1_HUMAN (26-180): 2.32e-55: 175: 60.65
+	Hs
		203628 DNMT1_HUMAN (1-1616): 0: 1717: 100.00		SUV91_HUMAN (4-135): 2.04e-36: 132: 19.70
+	Hs
		315971 DNMT1_HUMAN (1-1616): 0: 1717: 100.00		CBX6_HUMAN (11-103): 2.2e-24: 100: 31.18
+	Hs
		800543 DNM3B_HUMAN (1130-1325): 2.44e-41: 167: 17.65		CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00
+	Hs
		800563 DNM3A_HUMAN (1128-1326): 1.35e-36: 152: 17.87		CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00
+	Hs
		1027303 DNM3B_HUMAN (1130-1325): 2.44e-41: 167: 17.65		CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22
+	Hs
		1027214 MINT_HUMAN (5-706): 1.98e-35: 150: 12.71		CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22
+	Hs
		949904 DNM3B_HUMAN (1130-1325): 2.44e-41: 167: 17.65		CBX1_HUMAN (26-180): 2.32e-55: 175: 60.65
+	Dm
		399045 Q9VKB3_DROME (1139-1371): 3.2e-48: 178: 19.09		HP1_DROME (1-180): 3.46e-50: 162: 42.23
+	Hs
		949925 DNM3A_HUMAN (1128-1326): 1.35e-36: 152: 17.87		CBX1_HUMAN (26-180): 2.32e-55: 175: 60.65
+	Hs
		203801 DNM3B_HUMAN (1130-1325): 2.44e-41: 167: 17.65		SUV91_HUMAN (4-135): 2.04e-36: 132: 19.70
+	Hs
		800421 NIPBL_HUMAN (4-361): 1.81e-13: 78.5: 14.14		CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00
+	Hs
		203822 DNM3A_HUMAN (1128-1326): 1.35e-36: 152: 17.87		SUV91_HUMAN (4-135): 2.04e-36: 132: 19.70
+	Hs
		1027054 NIPBL_HUMAN (4-361): 1.81e-13: 78.5: 14.14		CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22
+	Hs
		123345 SMC3_HUMAN (112-523): 4.15e-40: 164: 12.53		CBX4_HUMAN (11-125): 7.54e-26: 105: 25.22
+	Mm
		291745 DNM3B_MOUSE (1124-1325): 1.81e-39: 161: 18.52		CBX2_MOUSE (10-111): 1.47e-24: 101: 31.37
+	Hs
		123351 DNM3A_HUMAN (1128-1326): 1.35e-36: 152: 17.87		CBX4_HUMAN (11-125): 7.54e-26: 105: 25.22
+	Hs
		949814 NIPBL_HUMAN (4-361): 1.81e-13: 78.5: 14.14		CBX1_HUMAN (26-180): 2.32e-55: 175: 60.65
+	At
		1276954 CMT3_ARATH (656-924): 1.39e-21: 104: 13.82		LHP1_ARATH (13-104): 2.12e-16: 78: 33.68