HitPredict

Interactor 1: U2AF2 (P26368)
Splicing factor U2AF 65 kDa subunit (U2 auxiliary factor 65 kDa subunit) (hU2AF(65)) (hU2AF65) (U2 snRNP auxiliary factor large subunit)
Gene: U2AF2

Interactor 2: RC3H2 (Q9HBD1)
Roquin-2 (EC 2.3.2.27) (Membrane-associated nucleic acid-binding protein) (RING finger and CCCH-type zinc finger domain-containing protein 2) (RING finger protein 164) (RING-type E3 ubiquitin transferase Roquin-2)
Gene: RC3H2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30209976
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~zf-CCCH
Common GO terms	GO:0003723 - RNA binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 475 Hs			1 1191
+	Hs
		1077504 ELAV1_HUMAN (149-471): 2.84e-73: 235: 14.79		RC3H2_HUMAN (1-1191): 0: 1105: 100.00
+	Hs
		1054598 RBM39_HUMAN (10-471): 4.93e-48: 175: 19.16		RC3H2_HUMAN (1-1191): 0: 1105: 100.00
+	Hs
		680490 TIA1_HUMAN (253-475): 5.63e-36: 138: 15.70		RC3H2_HUMAN (1-1191): 0: 1105: 100.00
+	Hs
		1335224 PUF60_HUMAN (92-474): 7.84e-23: 103: 21.50		RC3H2_HUMAN (1-1191): 0: 1105: 100.00
+	Hs
		1031467 PABP4_HUMAN (41-251): 2.07e-19: 93: 12.78		RC3H2_HUMAN (1-1191): 0: 1105: 100.00
+	Hs
		516698 PABP1_HUMAN (41-247): 3.26e-19: 92.6: 14.35		RC3H2_HUMAN (1-1191): 0: 1105: 100.00
+	Hs
		1329984 PABP3_HUMAN (41-247): 1.1e-18: 91.1: 14.80		RC3H2_HUMAN (1-1191): 0: 1105: 100.00
+	Hs
		641816 U2AF2_HUMAN (1-475): 3.12e-94: 294: 100.00		RC3H1_HUMAN (1-1108): 0: 788: 49.30
+	Hs
		1063223 SART3_HUMAN (10-377): 4.33e-86: 285: 22.52		RC3H1_HUMAN (1-1108): 0: 788: 49.30
+	Hs
		1077392 ELAV1_HUMAN (149-471): 2.84e-73: 235: 14.79		RC3H1_HUMAN (1-1108): 0: 788: 49.30
+	Hs
		1054374 RBM39_HUMAN (10-471): 4.93e-48: 175: 19.16		RC3H1_HUMAN (1-1108): 0: 788: 49.30
+	Hs
		1136342 PUF60_HUMAN (92-474): 7.84e-23: 103: 21.50		RC3H1_HUMAN (1-1108): 0: 788: 49.30
+	Hs
		1031360 PABP4_HUMAN (41-251): 2.07e-19: 93: 12.78		RC3H1_HUMAN (1-1108): 0: 788: 49.30
+	Hs
		516550 PABP1_HUMAN (41-247): 3.26e-19: 92.6: 14.35		RC3H1_HUMAN (1-1108): 0: 788: 49.30
+	Hs
		1136287 PABP3_HUMAN (41-247): 1.1e-18: 91.1: 14.80		RC3H1_HUMAN (1-1108): 0: 788: 49.30
+	Hs
		554269 U2AF2_HUMAN (1-475): 3.12e-94: 294: 100.00		MUC1_HUMAN (344-901): 6.29e-21: 102: 9.70
+	Dm
		375650 U2AF2_DROME (84-474): 6.66e-70: 230: 68.35		RPB1_DROME (644-998): 4.65e-09: 63.1: 10.28
+	Hs
		1054314 RBM39_HUMAN (10-471): 4.93e-48: 175: 19.16		MDC1_HUMAN (442-806): 1.14e-11: 71.8: 12.21
+	Hs
		963553 TIAR_HUMAN (251-473): 6.95e-33: 130: 14.67		CBP_HUMAN (556-893): 1.74e-09: 64.6: 9.77
+	Hs
		516595 PABP1_HUMAN (41-247): 3.26e-19: 92.6: 14.35		KMT2C_HUMAN (351-895): 4.49e-14: 79.7: 9.35