HitPredict

Interactor 1: HMGB2 (P26583)
High mobility group protein B2 (High mobility group protein 2) (HMG-2)
Gene: HMGB2

Interactor 2: SMC5 (Q8IY18)
Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (hSMC5)
Gene: SMC5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36373674
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003697 - single-stranded DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 209 Hs			1 1101
+	Hs
		449766 HMGB1_HUMAN (1-174): 3.53e-42: 143: 86.21		SMC5_HUMAN (1-1101): 5.88e-124: 409: 100.00
+	Hs
		175784 HMGB3_HUMAN (13-176): 1.26e-39: 136: 70.73		SMC5_HUMAN (1-1101): 5.88e-124: 409: 100.00
+	Hs
		297521 TOX4_HUMAN (91-170): 1.08e-31: 122: 33.75		SMC5_HUMAN (1-1101): 5.88e-124: 409: 100.00
+	Hs
		958962 TFAM_HUMAN (9-190): 7.47e-31: 114: 21.68		SMC5_HUMAN (1-1101): 5.88e-124: 409: 100.00
+	Hs
		1221753 HM20A_HUMAN (64-203): 2.16e-17: 81: 22.92		SMC5_HUMAN (1-1101): 5.88e-124: 409: 100.00
+	Hs
		1221662 CIC_HUMAN (3-100): 1.66e-11: 64.7: 22.45		SMC5_HUMAN (1-1101): 5.88e-124: 409: 100.00
+	Hs
		567725 UBF1_HUMAN (10-158): 1.47e-09: 58.9: 24.72		SMC5_HUMAN (1-1101): 5.88e-124: 409: 100.00
+	Hs
		996761 SSRP1_HUMAN (5-84): 2.82e-09: 57.9: 35.00		SMC5_HUMAN (1-1101): 5.88e-124: 409: 100.00
+	Hs
		818618 SOX2_HUMAN (3-94): 2.29e-23: 96.7: 22.83		SMC3_HUMAN (51-1061): 6.65e-82: 293: 13.91
+	Hs
		1301004 CIC_HUMAN (3-100): 1.66e-11: 64.7: 22.45		SMC3_HUMAN (51-1061): 6.65e-82: 293: 13.91
+	Hs
		311503 SOX2_HUMAN (3-94): 2.29e-23: 96.7: 22.83		SMC2_HUMAN (51-1055): 9.8e-55: 210: 11.41
+	Hs
		725110 SOX2_HUMAN (3-94): 2.29e-23: 96.7: 22.83		MYH10_HUMAN (114-762): 2.31e-22: 106: 10.60